Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.

After remarkable success of vector control campaigns worldwide, concerns about loss of immunity against Plasmodium falciparum due to lack of exposure to the parasite are relevant since an increase of severe cases in less immune individuals is expected. We present a mathematical model to investigate...

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Autores principales:	Cátia Bandeiras, Maria Jesus Trovoada, Lígia A Gonçalves, Cláudio R F Marinho, Louise Turner, Lars Hviid, Carlos Penha-Gonçalves, M Gabriela M Gomes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/36a0db755adf4f8abf855d4676f62fcb
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spelling	oai:doaj.org-article:36a0db755adf4f8abf855d4676f62fcb2021-11-18T08:33:11ZModeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.1932-620310.1371/journal.pone.0088110https://doaj.org/article/36a0db755adf4f8abf855d4676f62fcb2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24520349/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203After remarkable success of vector control campaigns worldwide, concerns about loss of immunity against Plasmodium falciparum due to lack of exposure to the parasite are relevant since an increase of severe cases in less immune individuals is expected. We present a mathematical model to investigate the impact of reducing exposure to the parasite on the immune repertoire against P. falciparum erythrocyte membrane protein 1 (PfEMP1) variants. The model was parameterized with data from Príncipe Island, West Africa, and applied to simulate two alternative transmission scenarios: one where control measures are continued to eventually drive the system to elimination; and another where the effort is interrupted after 6 years of its initiation and the system returns to the initial transmission potential. Population dynamics of parasite prevalence predict that in a few years infection levels return to the pre-control values, while the re-acquisition of the immune repertoire against PfEMP1 is slower, creating a window for increased severity. The model illustrates the consequences of loss of immune repertoire against PfEMP1 in a given setting and can be applied to other regions where similar data may be available.Cátia BandeirasMaria Jesus TrovoadaLígia A GonçalvesCláudio R F MarinhoLouise TurnerLars HviidCarlos Penha-GonçalvesM Gabriela M GomesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88110 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cátia Bandeiras Maria Jesus Trovoada Lígia A Gonçalves Cláudio R F Marinho Louise Turner Lars Hviid Carlos Penha-Gonçalves M Gabriela M Gomes Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.
description	After remarkable success of vector control campaigns worldwide, concerns about loss of immunity against Plasmodium falciparum due to lack of exposure to the parasite are relevant since an increase of severe cases in less immune individuals is expected. We present a mathematical model to investigate the impact of reducing exposure to the parasite on the immune repertoire against P. falciparum erythrocyte membrane protein 1 (PfEMP1) variants. The model was parameterized with data from Príncipe Island, West Africa, and applied to simulate two alternative transmission scenarios: one where control measures are continued to eventually drive the system to elimination; and another where the effort is interrupted after 6 years of its initiation and the system returns to the initial transmission potential. Population dynamics of parasite prevalence predict that in a few years infection levels return to the pre-control values, while the re-acquisition of the immune repertoire against PfEMP1 is slower, creating a window for increased severity. The model illustrates the consequences of loss of immune repertoire against PfEMP1 in a given setting and can be applied to other regions where similar data may be available.
format	article
author	Cátia Bandeiras Maria Jesus Trovoada Lígia A Gonçalves Cláudio R F Marinho Louise Turner Lars Hviid Carlos Penha-Gonçalves M Gabriela M Gomes
author_facet	Cátia Bandeiras Maria Jesus Trovoada Lígia A Gonçalves Cláudio R F Marinho Louise Turner Lars Hviid Carlos Penha-Gonçalves M Gabriela M Gomes
author_sort	Cátia Bandeiras
title	Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.
title_short	Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.
title_full	Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.
title_fullStr	Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.
title_full_unstemmed	Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.
title_sort	modeling malaria infection and immunity against variant surface antigens in príncipe island, west africa.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/36a0db755adf4f8abf855d4676f62fcb
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Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.

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