DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

Altered epigenetics is a feature of cancer but whether these changes occur early in tumour development is unclear. Here, the authors analyse methylation events in breast cancer and adjacent normal pairs, and show that methylation changes in the normal tissue are also found in the tumour, suggesting...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrew E Teschendorff, Yang Gao, Allison Jones, Matthias Ruebner, Matthias W. Beckmann, David L. Wachter, Peter A. Fasching, Martin Widschwendter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36a2ba29445c4d0cb50f78cab96cf024
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:36a2ba29445c4d0cb50f78cab96cf024
record_format	dspace
spelling	oai:doaj.org-article:36a2ba29445c4d0cb50f78cab96cf0242021-12-02T14:39:29ZDNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer10.1038/ncomms104782041-1723https://doaj.org/article/36a2ba29445c4d0cb50f78cab96cf0242016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10478https://doaj.org/toc/2041-1723Altered epigenetics is a feature of cancer but whether these changes occur early in tumour development is unclear. Here, the authors analyse methylation events in breast cancer and adjacent normal pairs, and show that methylation changes in the normal tissue are also found in the tumour, suggesting that some of these events occur early in cancer.Andrew E TeschendorffYang GaoAllison JonesMatthias RuebnerMatthias W. BeckmannDavid L. WachterPeter A. FaschingMartin WidschwendterNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew E Teschendorff Yang Gao Allison Jones Matthias Ruebner Matthias W. Beckmann David L. Wachter Peter A. Fasching Martin Widschwendter DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
description	Altered epigenetics is a feature of cancer but whether these changes occur early in tumour development is unclear. Here, the authors analyse methylation events in breast cancer and adjacent normal pairs, and show that methylation changes in the normal tissue are also found in the tumour, suggesting that some of these events occur early in cancer.
format	article
author	Andrew E Teschendorff Yang Gao Allison Jones Matthias Ruebner Matthias W. Beckmann David L. Wachter Peter A. Fasching Martin Widschwendter
author_facet	Andrew E Teschendorff Yang Gao Allison Jones Matthias Ruebner Matthias W. Beckmann David L. Wachter Peter A. Fasching Martin Widschwendter
author_sort	Andrew E Teschendorff
title	DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
title_short	DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
title_full	DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
title_fullStr	DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
title_full_unstemmed	DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
title_sort	dna methylation outliers in normal breast tissue identify field defects that are enriched in cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/36a2ba29445c4d0cb50f78cab96cf024
work_keys_str_mv	AT andreweteschendorff dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT yanggao dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT allisonjones dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT matthiasruebner dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT matthiaswbeckmann dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT davidlwachter dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT peterafasching dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer AT martinwidschwendter dnamethylationoutliersinnormalbreasttissueidentifyfielddefectsthatareenrichedincancer
_version_	1718390585064161280

DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer

Ejemplares similares