Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats

Abstract The association of exertional heat stroke (EHS) and testicular morphological changes affecting sperm quality, as well as the association of EHS and hypothalamic changes affecting sexual behavior, has yet to be elucidated. This study aimed to elucidate the effects of EHS on fertility, erecti...

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Autores principales:	Pei-Hsuan Lin, Kuan-Hua Huang, Yu-Feng Tian, Cheng-Hsien Lin, Chien-Ming Chao, Ling-Yu Tang, Kun-Lin Hsieh, Ching-Ping Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/36a320af95a34ae7bc9188120deb8096
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spelling	oai:doaj.org-article:36a320af95a34ae7bc9188120deb80962021-12-02T13:30:17ZExertional heat stroke on fertility, erectile function, and testicular morphology in male rats10.1038/s41598-021-83121-32045-2322https://doaj.org/article/36a320af95a34ae7bc9188120deb80962021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83121-3https://doaj.org/toc/2045-2322Abstract The association of exertional heat stroke (EHS) and testicular morphological changes affecting sperm quality, as well as the association of EHS and hypothalamic changes affecting sexual behavior, has yet to be elucidated. This study aimed to elucidate the effects of EHS on fertility, erectile function, and testicular morphology in male rats. Animals were exercised at higher room temperature (36 ℃ relative humidity 50%) to induce EHS, characterized by excessive hyperthermia, neurobehavioral deficits, hypothalamic cell damage, systemic inflammation, coagulopathy, and multiple organ injury. In particular, EHS animals had erectile dysfunction (as determined by measuring the changes of intracavernosal pressure and mean arterial pressure in response to electrical stimulation of cavernous nerves). Rats also displayed testicular temperature disruption, poorly differentiated seminiferous tubules, impaired sperm quality, and atrophy of interstitial Leydig cells, Sertoli cells, and peri-tubular cells in the testicular tissues accompanied by no spermatozoa and broken cells with pyknosis in their seminal vesicle and prostatitis. These EHS effects were still observed after 3 days following EHS onset, at least. Our findings provide a greater understanding of the effect of experimentally induced EHS on masculine sexual behavior, fertility, stress hormones, and morphology of both testis and prostate.Pei-Hsuan LinKuan-Hua HuangYu-Feng TianCheng-Hsien LinChien-Ming ChaoLing-Yu TangKun-Lin HsiehChing-Ping ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pei-Hsuan Lin Kuan-Hua Huang Yu-Feng Tian Cheng-Hsien Lin Chien-Ming Chao Ling-Yu Tang Kun-Lin Hsieh Ching-Ping Chang Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats
description	Abstract The association of exertional heat stroke (EHS) and testicular morphological changes affecting sperm quality, as well as the association of EHS and hypothalamic changes affecting sexual behavior, has yet to be elucidated. This study aimed to elucidate the effects of EHS on fertility, erectile function, and testicular morphology in male rats. Animals were exercised at higher room temperature (36 ℃ relative humidity 50%) to induce EHS, characterized by excessive hyperthermia, neurobehavioral deficits, hypothalamic cell damage, systemic inflammation, coagulopathy, and multiple organ injury. In particular, EHS animals had erectile dysfunction (as determined by measuring the changes of intracavernosal pressure and mean arterial pressure in response to electrical stimulation of cavernous nerves). Rats also displayed testicular temperature disruption, poorly differentiated seminiferous tubules, impaired sperm quality, and atrophy of interstitial Leydig cells, Sertoli cells, and peri-tubular cells in the testicular tissues accompanied by no spermatozoa and broken cells with pyknosis in their seminal vesicle and prostatitis. These EHS effects were still observed after 3 days following EHS onset, at least. Our findings provide a greater understanding of the effect of experimentally induced EHS on masculine sexual behavior, fertility, stress hormones, and morphology of both testis and prostate.
format	article
author	Pei-Hsuan Lin Kuan-Hua Huang Yu-Feng Tian Cheng-Hsien Lin Chien-Ming Chao Ling-Yu Tang Kun-Lin Hsieh Ching-Ping Chang
author_facet	Pei-Hsuan Lin Kuan-Hua Huang Yu-Feng Tian Cheng-Hsien Lin Chien-Ming Chao Ling-Yu Tang Kun-Lin Hsieh Ching-Ping Chang
author_sort	Pei-Hsuan Lin
title	Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats
title_short	Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats
title_full	Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats
title_fullStr	Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats
title_full_unstemmed	Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats
title_sort	exertional heat stroke on fertility, erectile function, and testicular morphology in male rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/36a320af95a34ae7bc9188120deb8096
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Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats

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