Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure.
Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n=48), European adults (naïve travelers, n=22; expatriates with few pr...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/36a45a57bc3641368cf0651fb3e2637d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:36a45a57bc3641368cf0651fb3e2637d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:36a45a57bc3641368cf0651fb3e2637d2021-11-18T07:56:38ZCytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure.1932-620310.1371/journal.pone.0055756https://doaj.org/article/36a45a57bc3641368cf0651fb3e2637d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23437061/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n=48), European adults (naïve travelers, n=22; expatriates with few prior malaria exposures, n=15) and Mozambican adults with long-life malaria exposure (n=99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-1(42) (P=0.030) and a P. falciparum isolate (P=0.002), as well as higher IL-12 (P=0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P ≤ 0.0090), IL-2 (P ≤ 0.0379) and IL-8 (P ≤ 0.0233). Children also had higher IL-12 (P=0.0001), IL-4 (P=0.003), IL-1β (P=0.024) and TNF (P=0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A T(H)1/pro-inflammatory response was the hallmark of non-immune subjects.Gemma MoncunillAlfredo MayorAlfons JiménezAugusto NhabombaLaura PuyolMaria N ManacaDiana BarriosPau CisteróCaterina GuinovartRuth AguilarAzucena BardajíMaría-Jesús PinazoEvelina AngovSheetij DuttaChetan E ChitnisJosé MuñozJoaquim GascónCarlota DobañoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55756 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Gemma Moncunill Alfredo Mayor Alfons Jiménez Augusto Nhabomba Laura Puyol Maria N Manaca Diana Barrios Pau Cisteró Caterina Guinovart Ruth Aguilar Azucena Bardají María-Jesús Pinazo Evelina Angov Sheetij Dutta Chetan E Chitnis José Muñoz Joaquim Gascón Carlota Dobaño Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| description |
Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n=48), European adults (naïve travelers, n=22; expatriates with few prior malaria exposures, n=15) and Mozambican adults with long-life malaria exposure (n=99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-1(42) (P=0.030) and a P. falciparum isolate (P=0.002), as well as higher IL-12 (P=0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P ≤ 0.0090), IL-2 (P ≤ 0.0379) and IL-8 (P ≤ 0.0233). Children also had higher IL-12 (P=0.0001), IL-4 (P=0.003), IL-1β (P=0.024) and TNF (P=0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A T(H)1/pro-inflammatory response was the hallmark of non-immune subjects. |
| format |
article |
| author |
Gemma Moncunill Alfredo Mayor Alfons Jiménez Augusto Nhabomba Laura Puyol Maria N Manaca Diana Barrios Pau Cisteró Caterina Guinovart Ruth Aguilar Azucena Bardají María-Jesús Pinazo Evelina Angov Sheetij Dutta Chetan E Chitnis José Muñoz Joaquim Gascón Carlota Dobaño |
| author_facet |
Gemma Moncunill Alfredo Mayor Alfons Jiménez Augusto Nhabomba Laura Puyol Maria N Manaca Diana Barrios Pau Cisteró Caterina Guinovart Ruth Aguilar Azucena Bardají María-Jesús Pinazo Evelina Angov Sheetij Dutta Chetan E Chitnis José Muñoz Joaquim Gascón Carlota Dobaño |
| author_sort |
Gemma Moncunill |
| title |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| title_short |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| title_full |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| title_fullStr |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| title_full_unstemmed |
Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| title_sort |
cytokine and antibody responses to plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/36a45a57bc3641368cf0651fb3e2637d |
| work_keys_str_mv |
AT gemmamoncunill cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT alfredomayor cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT alfonsjimenez cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT augustonhabomba cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT laurapuyol cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT marianmanaca cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT dianabarrios cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT paucistero cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT caterinaguinovart cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT ruthaguilar cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT azucenabardaji cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT mariajesuspinazo cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT evelinaangov cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT sheetijdutta cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT chetanechitnis cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT josemunoz cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT joaquimgascon cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure AT carlotadobano cytokineandantibodyresponsestoplasmodiumfalciparuminnaiveindividualsduringafirstmalariaepisodeeffectofageandmalariaexposure |
| _version_ |
1718422720788561920 |