Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

Ageing is associated with muscle atrophy, which negatively impacts quality of life. Here the authors show that expression of sestrins decreases during inactivity and that their overexpression prevents atrophy in mice via modulation of autophagy and protein degradation.

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Detalles Bibliográficos
Autores principales:	Jessica Segalés, Eusebio Perdiguero, Antonio L. Serrano, Pedro Sousa-Victor, Laura Ortet, Mercè Jardí, Andrei V. Budanov, Laura Garcia-Prat, Marco Sandri, David M. Thomson, Michael Karin, Jun Hee Lee, Pura Muñoz-Cánoves
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36ab756e6fc848bfb843ed2f784d654b
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spelling	oai:doaj.org-article:36ab756e6fc848bfb843ed2f784d654b2021-12-02T17:33:12ZSestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals10.1038/s41467-019-13832-92041-1723https://doaj.org/article/36ab756e6fc848bfb843ed2f784d654b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13832-9https://doaj.org/toc/2041-1723Ageing is associated with muscle atrophy, which negatively impacts quality of life. Here the authors show that expression of sestrins decreases during inactivity and that their overexpression prevents atrophy in mice via modulation of autophagy and protein degradation.Jessica SegalésEusebio PerdigueroAntonio L. SerranoPedro Sousa-VictorLaura OrtetMercè JardíAndrei V. BudanovLaura Garcia-PratMarco SandriDavid M. ThomsonMichael KarinJun Hee LeePura Muñoz-CánovesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessica Segalés Eusebio Perdiguero Antonio L. Serrano Pedro Sousa-Victor Laura Ortet Mercè Jardí Andrei V. Budanov Laura Garcia-Prat Marco Sandri David M. Thomson Michael Karin Jun Hee Lee Pura Muñoz-Cánoves Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
description	Ageing is associated with muscle atrophy, which negatively impacts quality of life. Here the authors show that expression of sestrins decreases during inactivity and that their overexpression prevents atrophy in mice via modulation of autophagy and protein degradation.
format	article
author	Jessica Segalés Eusebio Perdiguero Antonio L. Serrano Pedro Sousa-Victor Laura Ortet Mercè Jardí Andrei V. Budanov Laura Garcia-Prat Marco Sandri David M. Thomson Michael Karin Jun Hee Lee Pura Muñoz-Cánoves
author_facet	Jessica Segalés Eusebio Perdiguero Antonio L. Serrano Pedro Sousa-Victor Laura Ortet Mercè Jardí Andrei V. Budanov Laura Garcia-Prat Marco Sandri David M. Thomson Michael Karin Jun Hee Lee Pura Muñoz-Cánoves
author_sort	Jessica Segalés
title	Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
title_short	Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
title_full	Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
title_fullStr	Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
title_full_unstemmed	Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
title_sort	sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/36ab756e6fc848bfb843ed2f784d654b
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Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

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