A Review of Per- and Polyfluorinated Alkyl Substance Impairment of Reproduction

In this review article, we compiled peer-reviewed literature describing PFAS exposure and reproductive effects in animals and humans. The aim was to compare environmental occurrence and effects of the most prominent long-chain PFAS compounds and their short-chain replacements. Long-chain PFAS compou...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Weston S. Chambers, Jaida G. Hopkins, Sean M. Richards
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	PFAS reproduction impairment short-chain PFAS GenX ADONA F53B Toxicology. Poisons RA1190-1270
Acceso en línea:	https://doaj.org/article/36aca52986a34fb0b3a0dd1df4fc60ab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:36aca52986a34fb0b3a0dd1df4fc60ab
record_format	dspace
spelling	oai:doaj.org-article:36aca52986a34fb0b3a0dd1df4fc60ab2021-11-22T06:44:05ZA Review of Per- and Polyfluorinated Alkyl Substance Impairment of Reproduction2673-308010.3389/ftox.2021.732436https://doaj.org/article/36aca52986a34fb0b3a0dd1df4fc60ab2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/ftox.2021.732436/fullhttps://doaj.org/toc/2673-3080In this review article, we compiled peer-reviewed literature describing PFAS exposure and reproductive effects in animals and humans. The aim was to compare environmental occurrence and effects of the most prominent long-chain PFAS compounds and their short-chain replacements. Long-chain PFAS compounds are known to persist in the environment due to their chemical stability, and also known to bioaccumulate; hence, these compounds are being replaced globally. Indeed, PFOA and PFOS are considered long-chain “forever pollutants,” and thus the potential reproductive risk may continue for decades. Much less is known about their short-chain replacements despite the fact that they becoming more widespread in the environment. Short-chain PFAS are generally less bioaccumulative than long-chain, but they are more mobile and persistent in aquatic ecosystems. The three most prominent of these are commonly referred to as GenX, ADONA and F53B. The short-chain PFAS have similar physical and chemical properties as their predecessors; however, because they are relatively new, much less is known about the potential to disrupt reproduction. Indeed, high-quality epidemiological studies are needed to determine associations between short-chain PFAS exposure and effects on reproductive health. However, epidemiological evidence is mounting that long-chain PFAS exposure is associated with reproductive effects (i.e., decrease in fertility, reduced fetal growth and birth weight, pregnancy-induced hypertension and preeclampsia, thyroid hormone disruption during pregnancy, and preterm birth). Evidence from animal models and human cell lines indicates that short-chain PFAS similarly affect reproductive endpoints; however, epidemiological studies are scarce and inconsistent. Although short-chain PFAS have been quantified in drinking water and sediment worldwide, most of these studies did not focus on quantitation of GenX, ADONA, and F53B. There are also many other short-chain PFAS byproducts of manufacturing that have yet to be identified and studied. When sum total concentration of long- and short-chain PFAS are considered, the concentration rises by an order or magnitude or greater, as will the risk of exposure and subsequent reproductive effects.Weston S. ChambersJaida G. HopkinsSean M. RichardsSean M. RichardsFrontiers Media S.A.articlePFASreproduction impairmentshort-chain PFASGenXADONAF53BToxicology. PoisonsRA1190-1270ENFrontiers in Toxicology, Vol 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PFAS reproduction impairment short-chain PFAS GenX ADONA F53B Toxicology. Poisons RA1190-1270
spellingShingle	PFAS reproduction impairment short-chain PFAS GenX ADONA F53B Toxicology. Poisons RA1190-1270 Weston S. Chambers Jaida G. Hopkins Sean M. Richards Sean M. Richards A Review of Per- and Polyfluorinated Alkyl Substance Impairment of Reproduction
description	In this review article, we compiled peer-reviewed literature describing PFAS exposure and reproductive effects in animals and humans. The aim was to compare environmental occurrence and effects of the most prominent long-chain PFAS compounds and their short-chain replacements. Long-chain PFAS compounds are known to persist in the environment due to their chemical stability, and also known to bioaccumulate; hence, these compounds are being replaced globally. Indeed, PFOA and PFOS are considered long-chain “forever pollutants,” and thus the potential reproductive risk may continue for decades. Much less is known about their short-chain replacements despite the fact that they becoming more widespread in the environment. Short-chain PFAS are generally less bioaccumulative than long-chain, but they are more mobile and persistent in aquatic ecosystems. The three most prominent of these are commonly referred to as GenX, ADONA and F53B. The short-chain PFAS have similar physical and chemical properties as their predecessors; however, because they are relatively new, much less is known about the potential to disrupt reproduction. Indeed, high-quality epidemiological studies are needed to determine associations between short-chain PFAS exposure and effects on reproductive health. However, epidemiological evidence is mounting that long-chain PFAS exposure is associated with reproductive effects (i.e., decrease in fertility, reduced fetal growth and birth weight, pregnancy-induced hypertension and preeclampsia, thyroid hormone disruption during pregnancy, and preterm birth). Evidence from animal models and human cell lines indicates that short-chain PFAS similarly affect reproductive endpoints; however, epidemiological studies are scarce and inconsistent. Although short-chain PFAS have been quantified in drinking water and sediment worldwide, most of these studies did not focus on quantitation of GenX, ADONA, and F53B. There are also many other short-chain PFAS byproducts of manufacturing that have yet to be identified and studied. When sum total concentration of long- and short-chain PFAS are considered, the concentration rises by an order or magnitude or greater, as will the risk of exposure and subsequent reproductive effects.
format	article
author	Weston S. Chambers Jaida G. Hopkins Sean M. Richards Sean M. Richards
author_facet	Weston S. Chambers Jaida G. Hopkins Sean M. Richards Sean M. Richards
author_sort	Weston S. Chambers
title	A Review of Per- and Polyfluorinated Alkyl Substance Impairment of Reproduction
title_short	A Review of Per- and Polyfluorinated Alkyl Substance Impairment of Reproduction
title_full	A Review of Per- and Polyfluorinated Alkyl Substance Impairment of Reproduction
title_fullStr	A Review of Per- and Polyfluorinated Alkyl Substance Impairment of Reproduction
title_full_unstemmed	A Review of Per- and Polyfluorinated Alkyl Substance Impairment of Reproduction
title_sort	review of per- and polyfluorinated alkyl substance impairment of reproduction
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/36aca52986a34fb0b3a0dd1df4fc60ab
work_keys_str_mv	AT westonschambers areviewofperandpolyfluorinatedalkylsubstanceimpairmentofreproduction AT jaidaghopkins areviewofperandpolyfluorinatedalkylsubstanceimpairmentofreproduction AT seanmrichards areviewofperandpolyfluorinatedalkylsubstanceimpairmentofreproduction AT seanmrichards areviewofperandpolyfluorinatedalkylsubstanceimpairmentofreproduction AT westonschambers reviewofperandpolyfluorinatedalkylsubstanceimpairmentofreproduction AT jaidaghopkins reviewofperandpolyfluorinatedalkylsubstanceimpairmentofreproduction AT seanmrichards reviewofperandpolyfluorinatedalkylsubstanceimpairmentofreproduction AT seanmrichards reviewofperandpolyfluorinatedalkylsubstanceimpairmentofreproduction
_version_	1718418094082228224

A Review of Per- and Polyfluorinated Alkyl Substance Impairment of Reproduction

Ejemplares similares