Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis

Coronary artery disease caused by atherosclerosis is a major cause of morbidity and mortality around the world. Data from preclinical and clinical studies support the belief that atherosclerosis is an inflammatory disease that is mediated by innate and adaptive immune signaling mechanisms. This revi...

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Autores principales:	Cadence F. Lee, Rachel E. Carley, Celia A. Butler, Alan R. Morrison
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Racs atherosclerosis statins macrophage inflammation calcification Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/36ad6bd701014bdc9fd7475862b1110c
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spelling	oai:doaj.org-article:36ad6bd701014bdc9fd7475862b1110c2021-11-25T17:07:16ZRac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis10.3390/cells101128082073-4409https://doaj.org/article/36ad6bd701014bdc9fd7475862b1110c2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2808https://doaj.org/toc/2073-4409Coronary artery disease caused by atherosclerosis is a major cause of morbidity and mortality around the world. Data from preclinical and clinical studies support the belief that atherosclerosis is an inflammatory disease that is mediated by innate and adaptive immune signaling mechanisms. This review sought to highlight the role of Rac-mediated inflammatory signaling in the mechanisms driving atherosclerotic calcification. In addition, current clinical treatment strategies that are related to targeting hypercholesterolemia as a critical risk factor for atherosclerotic vascular disease are addressed in relation to the effects on Rac immune signaling and the implications for the future of targeting immune responses in the treatment of calcific atherosclerosis.Cadence F. LeeRachel E. CarleyCelia A. ButlerAlan R. MorrisonMDPI AGarticleRacsatherosclerosisstatinsmacrophageinflammationcalcificationBiology (General)QH301-705.5ENCells, Vol 10, Iss 2808, p 2808 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Racs atherosclerosis statins macrophage inflammation calcification Biology (General) QH301-705.5
spellingShingle	Racs atherosclerosis statins macrophage inflammation calcification Biology (General) QH301-705.5 Cadence F. Lee Rachel E. Carley Celia A. Butler Alan R. Morrison Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis
description	Coronary artery disease caused by atherosclerosis is a major cause of morbidity and mortality around the world. Data from preclinical and clinical studies support the belief that atherosclerosis is an inflammatory disease that is mediated by innate and adaptive immune signaling mechanisms. This review sought to highlight the role of Rac-mediated inflammatory signaling in the mechanisms driving atherosclerotic calcification. In addition, current clinical treatment strategies that are related to targeting hypercholesterolemia as a critical risk factor for atherosclerotic vascular disease are addressed in relation to the effects on Rac immune signaling and the implications for the future of targeting immune responses in the treatment of calcific atherosclerosis.
format	article
author	Cadence F. Lee Rachel E. Carley Celia A. Butler Alan R. Morrison
author_facet	Cadence F. Lee Rachel E. Carley Celia A. Butler Alan R. Morrison
author_sort	Cadence F. Lee
title	Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis
title_short	Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis
title_full	Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis
title_fullStr	Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis
title_full_unstemmed	Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis
title_sort	rac gtpase signaling in immune-mediated mechanisms of atherosclerosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/36ad6bd701014bdc9fd7475862b1110c
work_keys_str_mv	AT cadenceflee racgtpasesignalinginimmunemediatedmechanismsofatherosclerosis AT rachelecarley racgtpasesignalinginimmunemediatedmechanismsofatherosclerosis AT celiaabutler racgtpasesignalinginimmunemediatedmechanismsofatherosclerosis AT alanrmorrison racgtpasesignalinginimmunemediatedmechanismsofatherosclerosis
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Rac GTPase Signaling in Immune-Mediated Mechanisms of Atherosclerosis

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