Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration

Abstract Understanding the emotional reaction to loss, or frustration, is a critical problem for the field of mental health. Animal models of loss have pointed to the opioid system as a nexus of frustration, physical pain, and substance abuse. However, few attempts have been made to connect the resu...

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Autores principales:	Alan M. Daniel, Brenda G. Rushing, Karla Y. Tapia Menchaca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/36aef879aedb443a8e369596e4430f71
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spelling	oai:doaj.org-article:36aef879aedb443a8e369596e4430f712021-12-02T13:58:24ZVariation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration10.1038/s41598-020-78783-42045-2322https://doaj.org/article/36aef879aedb443a8e369596e4430f712020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78783-4https://doaj.org/toc/2045-2322Abstract Understanding the emotional reaction to loss, or frustration, is a critical problem for the field of mental health. Animal models of loss have pointed to the opioid system as a nexus of frustration, physical pain, and substance abuse. However, few attempts have been made to connect the results of animal models of loss to human behavior. Allelic differences in the human mu opioid receptor gene, notably the A118G single nucleotide polymorphism, have been linked to individual differences in pain sensitivity, depressive symptoms, and reward processing. The present study explored the relationship between A118G and behavior in two frustrating tasks in humans. Results showed that carriers of the mutant G-allele were slower to recover behavior following a reward downshift and abandoned a frustrating task earlier than those without the mutation. Additionally, G-carriers were more sensitive to physical pain. These results highlight the overlap between frustration and pain, and suggest that genetic variation in opioid tone may contribute to individual differences in vulnerability and resilience following emotional disturbances.Alan M. DanielBrenda G. RushingKarla Y. Tapia MenchacaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alan M. Daniel Brenda G. Rushing Karla Y. Tapia Menchaca Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration
description	Abstract Understanding the emotional reaction to loss, or frustration, is a critical problem for the field of mental health. Animal models of loss have pointed to the opioid system as a nexus of frustration, physical pain, and substance abuse. However, few attempts have been made to connect the results of animal models of loss to human behavior. Allelic differences in the human mu opioid receptor gene, notably the A118G single nucleotide polymorphism, have been linked to individual differences in pain sensitivity, depressive symptoms, and reward processing. The present study explored the relationship between A118G and behavior in two frustrating tasks in humans. Results showed that carriers of the mutant G-allele were slower to recover behavior following a reward downshift and abandoned a frustrating task earlier than those without the mutation. Additionally, G-carriers were more sensitive to physical pain. These results highlight the overlap between frustration and pain, and suggest that genetic variation in opioid tone may contribute to individual differences in vulnerability and resilience following emotional disturbances.
format	article
author	Alan M. Daniel Brenda G. Rushing Karla Y. Tapia Menchaca
author_facet	Alan M. Daniel Brenda G. Rushing Karla Y. Tapia Menchaca
author_sort	Alan M. Daniel
title	Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration
title_short	Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration
title_full	Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration
title_fullStr	Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration
title_full_unstemmed	Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration
title_sort	variation of the human mu-opioid receptor (oprm1) gene predicts vulnerability to frustration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/36aef879aedb443a8e369596e4430f71
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Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration

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