Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan

Abstract Background Potential drug–drug interactions (PDDIs) commonly occur because of aging and comorbidities in people living with human immunodeficiency virus (HIV; PLWH). Protease inhibitors and non-nucleoside reverse transcriptase inhibitors have been reported to cause PDDIs in these patients....

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Autores principales:	Yusuke Kunimoto, Ryosuke Matamura, Hiroshi Ikeda, Satoshi Fujii, Tomoko Kimyo, Manabu Kitagawa, Hiromasa Nakata, Masayoshi Kobune, Atsushi Miyamoto, Masahide Fukudo
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	HIV Potential drug–drug interaction Antiretroviral therapy Integrase strand transfer inhibitors Polypharmacy Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/36b085886ff641c9923eba261607d847
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spelling	oai:doaj.org-article:36b085886ff641c9923eba261607d8472021-12-05T12:03:13ZPotential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan10.1186/s40780-021-00226-72055-0294https://doaj.org/article/36b085886ff641c9923eba261607d8472021-12-01T00:00:00Zhttps://doi.org/10.1186/s40780-021-00226-7https://doaj.org/toc/2055-0294Abstract Background Potential drug–drug interactions (PDDIs) commonly occur because of aging and comorbidities in people living with human immunodeficiency virus (HIV; PLWH). Protease inhibitors and non-nucleoside reverse transcriptase inhibitors have been reported to cause PDDIs in these patients. However, there are few reports of PDDIs in the era of treatment using integrase strand transfer inhibitors. Therefore, we investigated PDDIs in Japanese PLWH receiving antiretroviral drugs (ARVs). Methods This was a cross-sectional observational study conducted in Japanese outpatients. All eligible patients who had received ARV therapy for at least 48 weeks were enrolled. The primary endpoint was the incidence of PDDIs detected using the Lexicomp® interface. Results Of the 71 eligible patients, 51 (71.8%) were prescribed concomitant non-ARV medications. In 21 patients (29.6%), PDDIs with the potential to reduce the effects of ARVs occurred, although the HIV load was suppressed in all cases. Polypharmacy (the use of ≥5 non-ARVs) was observed in 25 patients (35.2%). There was a significantly higher median number of non-ARV medications in the PDDI group than in the non-PDDI group (6 vs. 3, P < 0.001). Furthermore, the proportion of patients on polypharmacy was significantly higher in those with PDDIs than in those without PDDIs (81.0% vs. 26.7%, P < 0.001). Conclusions The incidence of PDDIs is relatively high in Japanese PLWH, even in the era of treatment using integrase strand transfer inhibitors. Therefore, it is important for patients and health care providers to be constantly aware of PDDIs associated with ARV treatment.Yusuke KunimotoRyosuke MatamuraHiroshi IkedaSatoshi FujiiTomoko KimyoManabu KitagawaHiromasa NakataMasayoshi KobuneAtsushi MiyamotoMasahide FukudoBMCarticleHIVPotential drug–drug interactionAntiretroviral therapyIntegrase strand transfer inhibitorsPolypharmacyTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENJournal of Pharmaceutical Health Care and Sciences, Vol 7, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV Potential drug–drug interaction Antiretroviral therapy Integrase strand transfer inhibitors Polypharmacy Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	HIV Potential drug–drug interaction Antiretroviral therapy Integrase strand transfer inhibitors Polypharmacy Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Yusuke Kunimoto Ryosuke Matamura Hiroshi Ikeda Satoshi Fujii Tomoko Kimyo Manabu Kitagawa Hiromasa Nakata Masayoshi Kobune Atsushi Miyamoto Masahide Fukudo Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan
description	Abstract Background Potential drug–drug interactions (PDDIs) commonly occur because of aging and comorbidities in people living with human immunodeficiency virus (HIV; PLWH). Protease inhibitors and non-nucleoside reverse transcriptase inhibitors have been reported to cause PDDIs in these patients. However, there are few reports of PDDIs in the era of treatment using integrase strand transfer inhibitors. Therefore, we investigated PDDIs in Japanese PLWH receiving antiretroviral drugs (ARVs). Methods This was a cross-sectional observational study conducted in Japanese outpatients. All eligible patients who had received ARV therapy for at least 48 weeks were enrolled. The primary endpoint was the incidence of PDDIs detected using the Lexicomp® interface. Results Of the 71 eligible patients, 51 (71.8%) were prescribed concomitant non-ARV medications. In 21 patients (29.6%), PDDIs with the potential to reduce the effects of ARVs occurred, although the HIV load was suppressed in all cases. Polypharmacy (the use of ≥5 non-ARVs) was observed in 25 patients (35.2%). There was a significantly higher median number of non-ARV medications in the PDDI group than in the non-PDDI group (6 vs. 3, P < 0.001). Furthermore, the proportion of patients on polypharmacy was significantly higher in those with PDDIs than in those without PDDIs (81.0% vs. 26.7%, P < 0.001). Conclusions The incidence of PDDIs is relatively high in Japanese PLWH, even in the era of treatment using integrase strand transfer inhibitors. Therefore, it is important for patients and health care providers to be constantly aware of PDDIs associated with ARV treatment.
format	article
author	Yusuke Kunimoto Ryosuke Matamura Hiroshi Ikeda Satoshi Fujii Tomoko Kimyo Manabu Kitagawa Hiromasa Nakata Masayoshi Kobune Atsushi Miyamoto Masahide Fukudo
author_facet	Yusuke Kunimoto Ryosuke Matamura Hiroshi Ikeda Satoshi Fujii Tomoko Kimyo Manabu Kitagawa Hiromasa Nakata Masayoshi Kobune Atsushi Miyamoto Masahide Fukudo
author_sort	Yusuke Kunimoto
title	Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan
title_short	Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan
title_full	Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan
title_fullStr	Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan
title_full_unstemmed	Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan
title_sort	potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in japan
publisher	BMC
publishDate	2021
url	https://doaj.org/article/36b085886ff641c9923eba261607d847
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Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan

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