Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations

Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations

Pancreatic ductal adenocarcinoma is a lethal human cancer with a poor 5-year overall survival rate. Here the authors perform an exome-wide analysis in a cohort of PDAC patients to identify three novel missense variants in PKN1, DOK2, and APOB genes, that are associated with PDAC risk.

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Detalles Bibliográficos
Autores principales: Jiang Chang, Jianbo Tian, Ying Zhu, Rong Zhong, Kan Zhai, Jiaoyuan Li, Juntao Ke, QiangQiang Han, Jiao Lou, Wei Chen, Beibei Zhu, Na Shen, Yi Zhang, Yajie Gong, Yang Yang, Danyi Zou, Xiating Peng, Zhi Zhang, Xuemei Zhang, Kun Huang, Ming Yang, Li Wang, Chen Wu, Dongxin Lin, Xiaoping Miao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/36b3c87cab784348903098fb5a6810b2
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Descripción
Sumario:Pancreatic ductal adenocarcinoma is a lethal human cancer with a poor 5-year overall survival rate. Here the authors perform an exome-wide analysis in a cohort of PDAC patients to identify three novel missense variants in PKN1, DOK2, and APOB genes, that are associated with PDAC risk.

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