Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations

Pancreatic ductal adenocarcinoma is a lethal human cancer with a poor 5-year overall survival rate. Here the authors perform an exome-wide analysis in a cohort of PDAC patients to identify three novel missense variants in PKN1, DOK2, and APOB genes, that are associated with PDAC risk.

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Detalles Bibliográficos
Autores principales:	Jiang Chang, Jianbo Tian, Ying Zhu, Rong Zhong, Kan Zhai, Jiaoyuan Li, Juntao Ke, QiangQiang Han, Jiao Lou, Wei Chen, Beibei Zhu, Na Shen, Yi Zhang, Yajie Gong, Yang Yang, Danyi Zou, Xiating Peng, Zhi Zhang, Xuemei Zhang, Kun Huang, Ming Yang, Li Wang, Chen Wu, Dongxin Lin, Xiaoping Miao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36b3c87cab784348903098fb5a6810b2
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spelling	oai:doaj.org-article:36b3c87cab784348903098fb5a6810b22021-12-02T15:34:29ZExome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations10.1038/s41467-018-06136-x2041-1723https://doaj.org/article/36b3c87cab784348903098fb5a6810b22018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06136-xhttps://doaj.org/toc/2041-1723Pancreatic ductal adenocarcinoma is a lethal human cancer with a poor 5-year overall survival rate. Here the authors perform an exome-wide analysis in a cohort of PDAC patients to identify three novel missense variants in PKN1, DOK2, and APOB genes, that are associated with PDAC risk.Jiang ChangJianbo TianYing ZhuRong ZhongKan ZhaiJiaoyuan LiJuntao KeQiangQiang HanJiao LouWei ChenBeibei ZhuNa ShenYi ZhangYajie GongYang YangDanyi ZouXiating PengZhi ZhangXuemei ZhangKun HuangMing YangLi WangChen WuDongxin LinXiaoping MiaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiang Chang Jianbo Tian Ying Zhu Rong Zhong Kan Zhai Jiaoyuan Li Juntao Ke QiangQiang Han Jiao Lou Wei Chen Beibei Zhu Na Shen Yi Zhang Yajie Gong Yang Yang Danyi Zou Xiating Peng Zhi Zhang Xuemei Zhang Kun Huang Ming Yang Li Wang Chen Wu Dongxin Lin Xiaoping Miao Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations
description	Pancreatic ductal adenocarcinoma is a lethal human cancer with a poor 5-year overall survival rate. Here the authors perform an exome-wide analysis in a cohort of PDAC patients to identify three novel missense variants in PKN1, DOK2, and APOB genes, that are associated with PDAC risk.
format	article
author	Jiang Chang Jianbo Tian Ying Zhu Rong Zhong Kan Zhai Jiaoyuan Li Juntao Ke QiangQiang Han Jiao Lou Wei Chen Beibei Zhu Na Shen Yi Zhang Yajie Gong Yang Yang Danyi Zou Xiating Peng Zhi Zhang Xuemei Zhang Kun Huang Ming Yang Li Wang Chen Wu Dongxin Lin Xiaoping Miao
author_facet	Jiang Chang Jianbo Tian Ying Zhu Rong Zhong Kan Zhai Jiaoyuan Li Juntao Ke QiangQiang Han Jiao Lou Wei Chen Beibei Zhu Na Shen Yi Zhang Yajie Gong Yang Yang Danyi Zou Xiating Peng Zhi Zhang Xuemei Zhang Kun Huang Ming Yang Li Wang Chen Wu Dongxin Lin Xiaoping Miao
author_sort	Jiang Chang
title	Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations
title_short	Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations
title_full	Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations
title_fullStr	Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations
title_full_unstemmed	Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations
title_sort	exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in chinese populations
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/36b3c87cab784348903098fb5a6810b2
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Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations

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