miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity

Tumours produce soluble factors that contribute to the expansion of Gr-1+CD11b+ immature myeloid cells with TGFβ dependent immune suppressive function. Here, the authors show miR-130a and miR-145 target TβRII and reprogram these cells by altering the cytokine microenvironment, improving anti-tumour...

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Autores principales:	Hiroki Ishii, Suman K. Vodnala, Bhagelu R. Achyut, Jae Young So, M. Christine Hollander, Tim F. Greten, Ashish Lal, Li Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36b455895b6a43af80a5ef29ba1eff98
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spelling	oai:doaj.org-article:36b455895b6a43af80a5ef29ba1eff982021-12-02T17:32:46ZmiR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity10.1038/s41467-018-05023-92041-1723https://doaj.org/article/36b455895b6a43af80a5ef29ba1eff982018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05023-9https://doaj.org/toc/2041-1723Tumours produce soluble factors that contribute to the expansion of Gr-1+CD11b+ immature myeloid cells with TGFβ dependent immune suppressive function. Here, the authors show miR-130a and miR-145 target TβRII and reprogram these cells by altering the cytokine microenvironment, improving anti-tumour immunity and inhibiting metastasis in preclinical mouse models.Hiroki IshiiSuman K. VodnalaBhagelu R. AchyutJae Young SoM. Christine HollanderTim F. GretenAshish LalLi YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroki Ishii Suman K. Vodnala Bhagelu R. Achyut Jae Young So M. Christine Hollander Tim F. Greten Ashish Lal Li Yang miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
description	Tumours produce soluble factors that contribute to the expansion of Gr-1+CD11b+ immature myeloid cells with TGFβ dependent immune suppressive function. Here, the authors show miR-130a and miR-145 target TβRII and reprogram these cells by altering the cytokine microenvironment, improving anti-tumour immunity and inhibiting metastasis in preclinical mouse models.
format	article
author	Hiroki Ishii Suman K. Vodnala Bhagelu R. Achyut Jae Young So M. Christine Hollander Tim F. Greten Ashish Lal Li Yang
author_facet	Hiroki Ishii Suman K. Vodnala Bhagelu R. Achyut Jae Young So M. Christine Hollander Tim F. Greten Ashish Lal Li Yang
author_sort	Hiroki Ishii
title	miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
title_short	miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
title_full	miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
title_fullStr	miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
title_full_unstemmed	miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
title_sort	mir-130a and mir-145 reprogram gr-1+cd11b+ myeloid cells and inhibit tumor metastasis through improved host immunity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/36b455895b6a43af80a5ef29ba1eff98
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miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity

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