Acute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking
Viviane Soares,1 Ivan Silveira de Avelar,2 Patrícia Espíndola Mota Venâncio,1 Deise AA Pires-Oliveira,1 Pedro Henrique de Almeida Silva,1 Amanda Rodrigues Borges,1 Gustavo Paz Estevez Ferreira Fonseca,3 Matias Noll4 1Programa de Pós-Graduaç&a...
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Dove Medical Press
2020
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oai:doaj.org-article:36b6fca6371748dd97319765298d058a2021-12-02T12:46:32ZAcute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking1178-7031https://doaj.org/article/36b6fca6371748dd97319765298d058a2020-11-01T00:00:00Zhttps://www.dovepress.com/acute-changes-in-interleukin-6-level-during-four-days-of-long-distance-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Viviane Soares,1 Ivan Silveira de Avelar,2 Patrícia Espíndola Mota Venâncio,1 Deise AA Pires-Oliveira,1 Pedro Henrique de Almeida Silva,1 Amanda Rodrigues Borges,1 Gustavo Paz Estevez Ferreira Fonseca,3 Matias Noll4 1Programa de Pós-Graduação em Movimento Humano e Reabilitação, Centro Universitário de Anápolis UniEVANGÉLICA, Anápolis, Goiás, Brazil; 2Faculdade da Polícia Militar, Curso de Educação Física, Goiania, Goiás, Brazil; 3Hospital Geral de Goiânia, Goiânia, Goiás, Brazil; 4 Instituto Federal Goiano (IF Goiano), Department of Public Health, Ceres, Goiás, BrazilCorrespondence: Viviane SoaresCentro Universitário de Anápolis, Avenida Universitária Km 3,5, Cidade Universitária, Anápolis, Goiás 75083-515, BrazilTel +55 62 3310-6688Email ftviviane@gmail.comBackground: Interleukin 6 (IL-6) has an inflammatory effect, and its concentration in serum increases during exercise. However, no studies have assessed acute changes in IL-6 concentration after consecutive days of extreme and long-term exercise.Objective: This study aimed to assess acute changes in serum IL-6 concentration during four days of long-distance walking.Methods: This prospective observational study assessed 25 athletes (aged 44.8 ± 9.1 years), who covered a total of 251 km in four days. Blood samples were collected daily to assess serum IL-6 concentrations. Repeated-measures analysis of variance (with Bonferroni’s post hoc test) and the Kruskal–Wallis H-test (with Dunn’s post hoc test) were used to investigate the differences between the measures.Results: The serum IL-6 concentrations were higher on the four days of walking (1st day: 26.8 ± 14.8; 2nd day: 14 ± 7.4; 3rd day: 9.4 ± 10.8; 4th day: 4.5 ± 0.2 pg/mL) when compared to pre-walk values (pre-walk: 2.2 ± 2.1 pg/mL; p < 0.001). On the first day, there was a tenfold increase compared to the pre-walk value.Conclusion: The inflammatory response increased the serum concentration of IL-6 after four days of exercise. With the passing of days, there were reductions but not to baseline values.Keywords: exercise, long-distance walk, inflammation, biomarker, interleukin-6, athletesSoares VSilveira de Avelar IEspíndola Mota Venâncio PPires-Oliveira DAAde Almeida Silva PHRodrigues Borges AFonseca GPEFNoll MDove Medical Pressarticleexerciselong-distance walkinflammationbiomarkerinterleukin-6athletesPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 871-878 (2020) |
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DOAJ |
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exercise long-distance walk inflammation biomarker interleukin-6 athletes Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
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exercise long-distance walk inflammation biomarker interleukin-6 athletes Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Soares V Silveira de Avelar I Espíndola Mota Venâncio P Pires-Oliveira DAA de Almeida Silva PH Rodrigues Borges A Fonseca GPEF Noll M Acute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking |
| description |
Viviane Soares,1 Ivan Silveira de Avelar,2 Patrícia Espíndola Mota Venâncio,1 Deise AA Pires-Oliveira,1 Pedro Henrique de Almeida Silva,1 Amanda Rodrigues Borges,1 Gustavo Paz Estevez Ferreira Fonseca,3 Matias Noll4 1Programa de Pós-Graduação em Movimento Humano e Reabilitação, Centro Universitário de Anápolis UniEVANGÉLICA, Anápolis, Goiás, Brazil; 2Faculdade da Polícia Militar, Curso de Educação Física, Goiania, Goiás, Brazil; 3Hospital Geral de Goiânia, Goiânia, Goiás, Brazil; 4 Instituto Federal Goiano (IF Goiano), Department of Public Health, Ceres, Goiás, BrazilCorrespondence: Viviane SoaresCentro Universitário de Anápolis, Avenida Universitária Km 3,5, Cidade Universitária, Anápolis, Goiás 75083-515, BrazilTel +55 62 3310-6688Email ftviviane@gmail.comBackground: Interleukin 6 (IL-6) has an inflammatory effect, and its concentration in serum increases during exercise. However, no studies have assessed acute changes in IL-6 concentration after consecutive days of extreme and long-term exercise.Objective: This study aimed to assess acute changes in serum IL-6 concentration during four days of long-distance walking.Methods: This prospective observational study assessed 25 athletes (aged 44.8 ± 9.1 years), who covered a total of 251 km in four days. Blood samples were collected daily to assess serum IL-6 concentrations. Repeated-measures analysis of variance (with Bonferroni’s post hoc test) and the Kruskal–Wallis H-test (with Dunn’s post hoc test) were used to investigate the differences between the measures.Results: The serum IL-6 concentrations were higher on the four days of walking (1st day: 26.8 ± 14.8; 2nd day: 14 ± 7.4; 3rd day: 9.4 ± 10.8; 4th day: 4.5 ± 0.2 pg/mL) when compared to pre-walk values (pre-walk: 2.2 ± 2.1 pg/mL; p < 0.001). On the first day, there was a tenfold increase compared to the pre-walk value.Conclusion: The inflammatory response increased the serum concentration of IL-6 after four days of exercise. With the passing of days, there were reductions but not to baseline values.Keywords: exercise, long-distance walk, inflammation, biomarker, interleukin-6, athletes |
| format |
article |
| author |
Soares V Silveira de Avelar I Espíndola Mota Venâncio P Pires-Oliveira DAA de Almeida Silva PH Rodrigues Borges A Fonseca GPEF Noll M |
| author_facet |
Soares V Silveira de Avelar I Espíndola Mota Venâncio P Pires-Oliveira DAA de Almeida Silva PH Rodrigues Borges A Fonseca GPEF Noll M |
| author_sort |
Soares V |
| title |
Acute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking |
| title_short |
Acute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking |
| title_full |
Acute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking |
| title_fullStr |
Acute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking |
| title_full_unstemmed |
Acute Changes in Interleukin-6 Level During Four Days of Long-Distance Walking |
| title_sort |
acute changes in interleukin-6 level during four days of long-distance walking |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/36b6fca6371748dd97319765298d058a |
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