DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia

QR Code

DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia

Abstract Peposertib (M3814) is a potent and selective DNA-PK inhibitor in early clinical development. It effectively blocks non-homologous end-joining repair of DNA double-strand breaks (DSB) and strongly potentiates the antitumor effect of ionizing radiation (IR) and topoisomerase II inhibitors. By...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Eric Haines, Yuki Nishida, Michael I. Carr, Rafael Heinz Montoya, Lauren B. Ostermann, Weiguo Zhang, Frank T. Zenke, Andree Blaukat, Michael Andreeff, Lyubomir T. Vassilev
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/36b7c6a88d6e4d8b9b33159cd731cb9e
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
par: Jieqiong Lou, et autres
Publié: (2020)

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks
par: Magdalena B. Rother, et autres
Publié: (2020)

DNA single-strand break-induced DNA damage response causes heart failure
par: Tomoaki Higo, et autres
Publié: (2017)

Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.
par: Yong Yang, et autres
Publié: (2008)

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
par: Sarah Cohen, et autres
Publié: (2018)

Essential factors for incompatible DNA end joining at chromosomal DNA double strand breaks in vivo.
par: Hideaki Ogiwara, et autres
Publié: (2011)

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break
par: Andrea M. Kaminski, et autres
Publié: (2020)

ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
par: Sonia Jimeno, et autres
Publié: (2021)

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
par: Judit Domingo-Prim, et autres
Publié: (2019)

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
par: Marie-Christine Caron, et autres
Publié: (2019)

Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks.
par: Bing Xu, et autres
Publié: (2011)

An OB-fold complex controls the repair pathways for DNA double-strand breaks
par: Shengxian Gao, et autres
Publié: (2018)

A scalable CRISPR/Cas9-based fluorescent reporter assay to study DNA double-strand break repair choice
par: Paris Roidos, et autres
Publié: (2020)

Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis.
par: Tamara Goldfarb, et autres
Publié: (2010)

Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors.
par: Slawomir Kumala, et autres
Publié: (2013)

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
par: Pauline Chanut, et autres
Publié: (2016)

HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair
par: Donna Li, et autres
Publié: (2020)

UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
par: Greg H. P. Ngo, et autres
Publié: (2021)

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
par: Gabriele A. Fontana, et autres
Publié: (2019)

Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks
par: Nobuhiko Muramoto, et autres
Publié: (2018)

RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair
par: Janusz Blasiak, et autres
Publié: (2021)

Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair
par: Thomas Kent, et autres
Publié: (2021)

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
par: Joe Nassour, et autres
Publié: (2016)

FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku
par: Hanyong Jin, et autres
Publié: (2020)

DNA double-strand breaks in telophase lead to coalescence between segregated sister chromatid loci
par: Jessel Ayra-Plasencia, et autres
Publié: (2019)

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks
par: Winston X. Yan, et autres
Publié: (2017)

DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair.
par: Aya Kurosawa, et autres
Publié: (2013)

AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway
par: Jiangman Lou, et autres
Publié: (2017)

DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange.
par: Hungjiun Liaw, et autres
Publié: (2011)

Quantitative sensing and signalling of single-stranded DNA during the DNA damage response
par: Susanne C. S. Bantele, et autres
Publié: (2019)

Distribution of Holliday junctions and repair forks during Escherichia coli DNA double-strand break repair.
par: Tahirah Yasmin, et autres
Publié: (2021)

DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
par: Hiro Sato, et autres
Publié: (2017)

Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance
par: Qinglei Hang, et autres
Publié: (2021)

Correction: Corrigendum: Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
par: Pauline Chanut, et autres
Publié: (2017)

Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells
par: Huifen Cao, et autres
Publié: (2019)

DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
par: Xiao Xiao, et autres
Publié: (2018)

The chromatin remodeler Chd1 supports MRX and Exo1 functions in resection of DNA double-strand breaks.
par: Marco Gnugnoli, et autres
Publié: (2021)

Publisher Correction: DNA double-strand breaks in telophase lead to coalescence between segregated sister chromatid loci
par: Jessel Ayra-Plasencia, et autres
Publié: (2019)

Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
par: Geun-Hyoung Ha, et autres
Publié: (2019)

DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes.
par: Wai Shan Yuen, et autres
Publié: (2012)