Functional genetic encoding of sulfotyrosine in mammalian cells

Protein tyrosine O-sulfation is crucial for biomolecular interactions. Here the authors report in vitro engineering and in vivo validation of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfotyrosine in mammalian cells.

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Bibliographic Details
Main Authors:	Xinyuan He, Yan Chen, Daisy Guiza Beltran, Maia Kelly, Bin Ma, Justin Lawrie, Feng Wang, Eric Dodds, Limei Zhang, Jiantao Guo, Wei Niu
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/36b85aeda1574a44937f61b9db749e3c
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id	oai:doaj.org-article:36b85aeda1574a44937f61b9db749e3c
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spelling	oai:doaj.org-article:36b85aeda1574a44937f61b9db749e3c2021-12-02T15:15:06ZFunctional genetic encoding of sulfotyrosine in mammalian cells10.1038/s41467-020-18629-92041-1723https://doaj.org/article/36b85aeda1574a44937f61b9db749e3c2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18629-9https://doaj.org/toc/2041-1723Protein tyrosine O-sulfation is crucial for biomolecular interactions. Here the authors report in vitro engineering and in vivo validation of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfotyrosine in mammalian cells.Xinyuan HeYan ChenDaisy Guiza BeltranMaia KellyBin MaJustin LawrieFeng WangEric DoddsLimei ZhangJiantao GuoWei NiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinyuan He Yan Chen Daisy Guiza Beltran Maia Kelly Bin Ma Justin Lawrie Feng Wang Eric Dodds Limei Zhang Jiantao Guo Wei Niu Functional genetic encoding of sulfotyrosine in mammalian cells
description	Protein tyrosine O-sulfation is crucial for biomolecular interactions. Here the authors report in vitro engineering and in vivo validation of a tyrosyl-tRNA synthetase mutant for the genetic encoding of sulfotyrosine in mammalian cells.
format	article
author	Xinyuan He Yan Chen Daisy Guiza Beltran Maia Kelly Bin Ma Justin Lawrie Feng Wang Eric Dodds Limei Zhang Jiantao Guo Wei Niu
author_facet	Xinyuan He Yan Chen Daisy Guiza Beltran Maia Kelly Bin Ma Justin Lawrie Feng Wang Eric Dodds Limei Zhang Jiantao Guo Wei Niu
author_sort	Xinyuan He
title	Functional genetic encoding of sulfotyrosine in mammalian cells
title_short	Functional genetic encoding of sulfotyrosine in mammalian cells
title_full	Functional genetic encoding of sulfotyrosine in mammalian cells
title_fullStr	Functional genetic encoding of sulfotyrosine in mammalian cells
title_full_unstemmed	Functional genetic encoding of sulfotyrosine in mammalian cells
title_sort	functional genetic encoding of sulfotyrosine in mammalian cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/36b85aeda1574a44937f61b9db749e3c
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Functional genetic encoding of sulfotyrosine in mammalian cells

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