The definition of tuberculosis infection based on the spectrum of tuberculosis disease

Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB) infection. This term was used to define “a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens through tests such as the tuberculin skin test (TST) or an interferon-γ rel...

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Autores principales:	Giovanni Battista Migliori, Catherine W.M. Ong, Linda Petrone, Lia D'Ambrosio, Rosella Centis, Delia Goletti
Formato:	article
Lenguaje:	EN
Publicado:	European Respiratory Society 2021
Materias:	Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/36b94407d0054653aa1067c2fd020140
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spelling	oai:doaj.org-article:36b94407d0054653aa1067c2fd0201402021-11-24T07:45:28ZThe definition of tuberculosis infection based on the spectrum of tuberculosis disease1810-68382073-473510.1183/20734735.0079-2021https://doaj.org/article/36b94407d0054653aa1067c2fd0201402021-09-01T00:00:00Zhttp://breathe.ersjournals.com/content/17/3/210079.fullhttps://doaj.org/toc/1810-6838https://doaj.org/toc/2073-4735Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB) infection. This term was used to define “a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens through tests such as the tuberculin skin test (TST) or an interferon-γ release assay (IGRA) without clinically active TB”. Recent evidence indicates that the spectrum from TB infection to TB disease is much more complex, including a “continuum” of situations didactically reported as uninfected individual, TB infection, incipient TB, subclinical TB without signs/symptoms, subclinical TB with unrecognised signs/symptoms, and TB disease with signs/symptoms. Recent evidence suggests that subclinical TB is responsible for important M. tuberculosis transmission. This review describes the different stages described above and their relationships. It also summarises the new developments in prevention, diagnosis and treatment of TB infection as well as their public health and policy implications. Educational aims To describe the evolution of the definition of “tuberculosis infection” and didactically describe the continuum of stages existing between TB infection and disease. To discuss the recommended approaches to prevent, diagnose and treat TB infection.Giovanni Battista MiglioriCatherine W.M. OngLinda PetroneLia D'AmbrosioRosella CentisDelia GolettiEuropean Respiratory SocietyarticleDiseases of the respiratory systemRC705-779ENBreathe, Vol 17, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the respiratory system RC705-779
spellingShingle	Diseases of the respiratory system RC705-779 Giovanni Battista Migliori Catherine W.M. Ong Linda Petrone Lia D'Ambrosio Rosella Centis Delia Goletti The definition of tuberculosis infection based on the spectrum of tuberculosis disease
description	Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB) infection. This term was used to define “a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens through tests such as the tuberculin skin test (TST) or an interferon-γ release assay (IGRA) without clinically active TB”. Recent evidence indicates that the spectrum from TB infection to TB disease is much more complex, including a “continuum” of situations didactically reported as uninfected individual, TB infection, incipient TB, subclinical TB without signs/symptoms, subclinical TB with unrecognised signs/symptoms, and TB disease with signs/symptoms. Recent evidence suggests that subclinical TB is responsible for important M. tuberculosis transmission. This review describes the different stages described above and their relationships. It also summarises the new developments in prevention, diagnosis and treatment of TB infection as well as their public health and policy implications. Educational aims To describe the evolution of the definition of “tuberculosis infection” and didactically describe the continuum of stages existing between TB infection and disease. To discuss the recommended approaches to prevent, diagnose and treat TB infection.
format	article
author	Giovanni Battista Migliori Catherine W.M. Ong Linda Petrone Lia D'Ambrosio Rosella Centis Delia Goletti
author_facet	Giovanni Battista Migliori Catherine W.M. Ong Linda Petrone Lia D'Ambrosio Rosella Centis Delia Goletti
author_sort	Giovanni Battista Migliori
title	The definition of tuberculosis infection based on the spectrum of tuberculosis disease
title_short	The definition of tuberculosis infection based on the spectrum of tuberculosis disease
title_full	The definition of tuberculosis infection based on the spectrum of tuberculosis disease
title_fullStr	The definition of tuberculosis infection based on the spectrum of tuberculosis disease
title_full_unstemmed	The definition of tuberculosis infection based on the spectrum of tuberculosis disease
title_sort	definition of tuberculosis infection based on the spectrum of tuberculosis disease
publisher	European Respiratory Society
publishDate	2021
url	https://doaj.org/article/36b94407d0054653aa1067c2fd020140
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The definition of tuberculosis infection based on the spectrum of tuberculosis disease

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