New loci and neuronal pathways for resilience to heat stress in cattle

Abstract While understanding the genetic basis of heat tolerance is crucial in the context of global warming’s effect on humans, livestock, and wildlife, the specific genetic variants and biological features that confer thermotolerance in animals are still not well characterized. We used dairy cows...

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Autores principales:	Evans K. Cheruiyot, Mekonnen Haile-Mariam, Benjamin G. Cocks, Iona M. MacLeod, Ruidong Xiang, Jennie E. Pryce
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/36bc76d06a1140c7a17e3b0c2e32f15a
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spelling	oai:doaj.org-article:36bc76d06a1140c7a17e3b0c2e32f15a2021-12-02T15:10:54ZNew loci and neuronal pathways for resilience to heat stress in cattle10.1038/s41598-021-95816-82045-2322https://doaj.org/article/36bc76d06a1140c7a17e3b0c2e32f15a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95816-8https://doaj.org/toc/2045-2322Abstract While understanding the genetic basis of heat tolerance is crucial in the context of global warming’s effect on humans, livestock, and wildlife, the specific genetic variants and biological features that confer thermotolerance in animals are still not well characterized. We used dairy cows as a model to study heat tolerance because they are lactating, and therefore often prone to thermal stress. The data comprised almost 0.5 million milk records (milk, fat, and proteins) of 29,107 Australian Holsteins, each having around 15 million imputed sequence variants. Dairy animals often reduce their milk production when temperature and humidity rise; thus, the phenotypes used to measure an individual’s heat tolerance were defined as the rate of milk production decline (slope traits) with a rising temperature–humidity index. With these slope traits, we performed a genome-wide association study (GWAS) using different approaches, including conditional analyses, to correct for the relationship between heat tolerance and level of milk production. The results revealed multiple novel loci for heat tolerance, including 61 potential functional variants at sites highly conserved across 100 vertebrate species. Moreover, it was interesting that specific candidate variants and genes are related to the neuronal system (ITPR1, ITPR2, and GRIA4) and neuroactive ligand–receptor interaction functions for heat tolerance (NPFFR2, CALCR, and GHR), providing a novel insight that can help to develop genetic and management approaches to combat heat stress.Evans K. CheruiyotMekonnen Haile-MariamBenjamin G. CocksIona M. MacLeodRuidong XiangJennie E. PryceNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Evans K. Cheruiyot Mekonnen Haile-Mariam Benjamin G. Cocks Iona M. MacLeod Ruidong Xiang Jennie E. Pryce New loci and neuronal pathways for resilience to heat stress in cattle
description	Abstract While understanding the genetic basis of heat tolerance is crucial in the context of global warming’s effect on humans, livestock, and wildlife, the specific genetic variants and biological features that confer thermotolerance in animals are still not well characterized. We used dairy cows as a model to study heat tolerance because they are lactating, and therefore often prone to thermal stress. The data comprised almost 0.5 million milk records (milk, fat, and proteins) of 29,107 Australian Holsteins, each having around 15 million imputed sequence variants. Dairy animals often reduce their milk production when temperature and humidity rise; thus, the phenotypes used to measure an individual’s heat tolerance were defined as the rate of milk production decline (slope traits) with a rising temperature–humidity index. With these slope traits, we performed a genome-wide association study (GWAS) using different approaches, including conditional analyses, to correct for the relationship between heat tolerance and level of milk production. The results revealed multiple novel loci for heat tolerance, including 61 potential functional variants at sites highly conserved across 100 vertebrate species. Moreover, it was interesting that specific candidate variants and genes are related to the neuronal system (ITPR1, ITPR2, and GRIA4) and neuroactive ligand–receptor interaction functions for heat tolerance (NPFFR2, CALCR, and GHR), providing a novel insight that can help to develop genetic and management approaches to combat heat stress.
format	article
author	Evans K. Cheruiyot Mekonnen Haile-Mariam Benjamin G. Cocks Iona M. MacLeod Ruidong Xiang Jennie E. Pryce
author_facet	Evans K. Cheruiyot Mekonnen Haile-Mariam Benjamin G. Cocks Iona M. MacLeod Ruidong Xiang Jennie E. Pryce
author_sort	Evans K. Cheruiyot
title	New loci and neuronal pathways for resilience to heat stress in cattle
title_short	New loci and neuronal pathways for resilience to heat stress in cattle
title_full	New loci and neuronal pathways for resilience to heat stress in cattle
title_fullStr	New loci and neuronal pathways for resilience to heat stress in cattle
title_full_unstemmed	New loci and neuronal pathways for resilience to heat stress in cattle
title_sort	new loci and neuronal pathways for resilience to heat stress in cattle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/36bc76d06a1140c7a17e3b0c2e32f15a
work_keys_str_mv	AT evanskcheruiyot newlociandneuronalpathwaysforresiliencetoheatstressincattle AT mekonnenhailemariam newlociandneuronalpathwaysforresiliencetoheatstressincattle AT benjamingcocks newlociandneuronalpathwaysforresiliencetoheatstressincattle AT ionammacleod newlociandneuronalpathwaysforresiliencetoheatstressincattle AT ruidongxiang newlociandneuronalpathwaysforresiliencetoheatstressincattle AT jennieepryce newlociandneuronalpathwaysforresiliencetoheatstressincattle
_version_	1718387622072549376

New loci and neuronal pathways for resilience to heat stress in cattle

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