Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.

<h4>Unlabelled</h4>Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Peter J Lally, David L Price, Shreela S Pauliah, Alan Bainbridge, Justin Kurien, Neeraja Sivasamy, Frances M Cowan, Guhan Balraj, Manjula Ayer, Kariyapilly Satheesan, Sreejith Ceebi, Angie Wade, Ravi Swamy, Shaji Padinjattel, Betty Hutchon, Madhava Vijayakumar, Mohandas Nair, Krishnakumar Padinharath, Hui Zhang, Ernest B Cady, Seetha Shankaran, Sudhin Thayyil
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/36be1191cd8143eb86e90626782743d1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:36be1191cd8143eb86e90626782743d1
record_format	dspace
spelling	oai:doaj.org-article:36be1191cd8143eb86e90626782743d12021-11-18T08:33:42ZNeonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.1932-620310.1371/journal.pone.0087874https://doaj.org/article/36be1191cd8143eb86e90626782743d12014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24505327/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Unlabelled</h4>Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic resonance (MR) biomarkers to characterise perinatal brain injury, and examined early childhood outcomes in South India.<h4>Methods</h4>We recruited consecutive term or near term infants with evidence of perinatal asphyxia and a Thompson encephalopathy score ≥6 within 6 h of birth, over 6 months. We performed conventional MR imaging, diffusion tensor MR imaging and thalamic proton MR spectroscopy within 3 weeks of birth. We computed group-wise differences in white matter fractional anisotropy (FA) using tract based spatial statistics. We allocated Sarnat encephalopathy stage aged 3 days, and evaluated neurodevelopmental outcomes aged 3½ years using Bayley III.<h4>Results</h4>Of the 54 neonates recruited, Sarnat staging was mild in 30 (56%); moderate in 15 (28%) and severe in 6 (11%), with no encephalopathy in 3 (6%). Six infants died. Of the 48 survivors, 44 had images available for analysis. In these infants, imaging indicated perinatal rather than established antenatal origins to injury. Abnormalities were frequently observed in white matter (n = 40, 91%) and cortex (n = 31, 70%) while only 12 (27%) had abnormal basal ganglia/thalami. Reduced white matter FA was associated with Sarnat stage, deep grey nuclear injury, and MR spectroscopy N-acetylaspartate/choline, but not early Thompson scores. Outcome data were obtained in 44 infants (81%) with 38 (79%) survivors examined aged 3½ years; of these, 16 (42%) had adverse neurodevelopmental outcomes.<h4>Conclusions</h4>No infants had evidence for established brain lesions, suggesting potentially treatable perinatal origins. White matter injury was more common than deep brain nuclei injury. Our results support the need for rigorous evaluation of the efficacy of rescue hypothermic neuroprotection in low- and middle-income countries.Peter J LallyDavid L PriceShreela S PauliahAlan BainbridgeJustin KurienNeeraja SivasamyFrances M CowanGuhan BalrajManjula AyerKariyapilly SatheesanSreejith CeebiAngie WadeRavi SwamyShaji PadinjattelBetty HutchonMadhava VijayakumarMohandas NairKrishnakumar PadinharathHui ZhangErnest B CadySeetha ShankaranSudhin ThayyilPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e87874 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter J Lally David L Price Shreela S Pauliah Alan Bainbridge Justin Kurien Neeraja Sivasamy Frances M Cowan Guhan Balraj Manjula Ayer Kariyapilly Satheesan Sreejith Ceebi Angie Wade Ravi Swamy Shaji Padinjattel Betty Hutchon Madhava Vijayakumar Mohandas Nair Krishnakumar Padinharath Hui Zhang Ernest B Cady Seetha Shankaran Sudhin Thayyil Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.
description	<h4>Unlabelled</h4>Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic resonance (MR) biomarkers to characterise perinatal brain injury, and examined early childhood outcomes in South India.<h4>Methods</h4>We recruited consecutive term or near term infants with evidence of perinatal asphyxia and a Thompson encephalopathy score ≥6 within 6 h of birth, over 6 months. We performed conventional MR imaging, diffusion tensor MR imaging and thalamic proton MR spectroscopy within 3 weeks of birth. We computed group-wise differences in white matter fractional anisotropy (FA) using tract based spatial statistics. We allocated Sarnat encephalopathy stage aged 3 days, and evaluated neurodevelopmental outcomes aged 3½ years using Bayley III.<h4>Results</h4>Of the 54 neonates recruited, Sarnat staging was mild in 30 (56%); moderate in 15 (28%) and severe in 6 (11%), with no encephalopathy in 3 (6%). Six infants died. Of the 48 survivors, 44 had images available for analysis. In these infants, imaging indicated perinatal rather than established antenatal origins to injury. Abnormalities were frequently observed in white matter (n = 40, 91%) and cortex (n = 31, 70%) while only 12 (27%) had abnormal basal ganglia/thalami. Reduced white matter FA was associated with Sarnat stage, deep grey nuclear injury, and MR spectroscopy N-acetylaspartate/choline, but not early Thompson scores. Outcome data were obtained in 44 infants (81%) with 38 (79%) survivors examined aged 3½ years; of these, 16 (42%) had adverse neurodevelopmental outcomes.<h4>Conclusions</h4>No infants had evidence for established brain lesions, suggesting potentially treatable perinatal origins. White matter injury was more common than deep brain nuclei injury. Our results support the need for rigorous evaluation of the efficacy of rescue hypothermic neuroprotection in low- and middle-income countries.
format	article
author	Peter J Lally David L Price Shreela S Pauliah Alan Bainbridge Justin Kurien Neeraja Sivasamy Frances M Cowan Guhan Balraj Manjula Ayer Kariyapilly Satheesan Sreejith Ceebi Angie Wade Ravi Swamy Shaji Padinjattel Betty Hutchon Madhava Vijayakumar Mohandas Nair Krishnakumar Padinharath Hui Zhang Ernest B Cady Seetha Shankaran Sudhin Thayyil
author_facet	Peter J Lally David L Price Shreela S Pauliah Alan Bainbridge Justin Kurien Neeraja Sivasamy Frances M Cowan Guhan Balraj Manjula Ayer Kariyapilly Satheesan Sreejith Ceebi Angie Wade Ravi Swamy Shaji Padinjattel Betty Hutchon Madhava Vijayakumar Mohandas Nair Krishnakumar Padinharath Hui Zhang Ernest B Cady Seetha Shankaran Sudhin Thayyil
author_sort	Peter J Lally
title	Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.
title_short	Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.
title_full	Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.
title_fullStr	Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.
title_full_unstemmed	Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.
title_sort	neonatal encephalopathic cerebral injury in south india assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/36be1191cd8143eb86e90626782743d1
work_keys_str_mv	AT peterjlally neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT davidlprice neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT shreelaspauliah neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT alanbainbridge neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT justinkurien neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT neerajasivasamy neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT francesmcowan neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT guhanbalraj neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT manjulaayer neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT kariyapillysatheesan neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT sreejithceebi neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT angiewade neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT raviswamy neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT shajipadinjattel neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT bettyhutchon neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT madhavavijayakumar neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT mohandasnair neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT krishnakumarpadinharath neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT huizhang neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT ernestbcady neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT seethashankaran neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome AT sudhinthayyil neonatalencephalopathiccerebralinjuryinsouthindiaassessedbyperinatalmagneticresonancebiomarkersandearlychildhoodneurodevelopmentaloutcome
_version_	1718421613919076352

Neonatal encephalopathic cerebral injury in South India assessed by perinatal magnetic resonance biomarkers and early childhood neurodevelopmental outcome.

Ejemplares similares