Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women

Background. Obesity is associated with the risk of spontaneous preterm birth. Hexoprenaline is the effective and most widely used tocolytic agent, possessing however a significant number of side effects. The effect of hexoprenaline tocolysis on heart rate variability, lipid spectrum and glycaemia le...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	L. V. Gureeva, O. M. Chistyakova, E. K. Paramonova, O. V. Radkov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	threatening preterm labor, obesity, hexoprenaline, heart rate variability, lipids, glucose Science Q
Acceso en línea:	https://doaj.org/article/36bea93db46f495887017ca233206076
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:36bea93db46f495887017ca233206076
record_format	dspace
spelling	oai:doaj.org-article:36bea93db46f495887017ca2332060762021-11-23T06:14:45ZInfluence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women2541-94202587-959610.29413/ABS.2021-6.1.1https://doaj.org/article/36bea93db46f495887017ca2332060762021-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2604https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Obesity is associated with the risk of spontaneous preterm birth. Hexoprenaline is the effective and most widely used tocolytic agent, possessing however a significant number of side effects. The effect of hexoprenaline tocolysis on heart rate variability, lipid spectrum and glycaemia level in obese pregnant women remain unexplored.Aim of the research. To study the effect of tocolytic therapy with hexoprenaline on heart rate variability, lipid spectrum and glycemic level in obese pregnant women.Materials and methods. The study included two groups of pregnant women with threatened preterm labor who received tocolysis with hexoprenaline. One group consisted of 68 obese patients, the other – 72 non-obese pregnant women (control group). Patients underwent Holter monitoring. Fasting serum glucose and lipids spectrum were measured before starting tocolytic therapy and after 24 hours of tocolysis.Results. In obese pregnant women with hexoprenaline infusion, the heart rate, the 24-hours number of supraventricular extrasystoles and ventricular extrasystoles during the day are significantly higher. Frequency domain parameters, very low frequency during the day, low frequency at night and 24-hours high frequency were significantly decreased than in control group. After a day of tocolysis in obese pregnant women, the level of total cholesterol, low density lipoproteins, triglycerides, and glucose significantly increases when compared with the results before therapy. For patients in the control group treated with hexoprenaline, only the concentration of high-density lipoproteins is increased.Conclusion. Obesity in pregnant women receiving hexoprenaline tocolysis is associated with low heart rate variability and an increase in the number of cardiac arrhythmias, as well as lipid disorders and an increase in glucose level.L. V. GureevaO. M. ChistyakovaE. K. ParamonovaO. V. RadkovScientific Сentre for Family Health and Human Reproduction Problemsarticlethreatening preterm labor, obesity, hexoprenaline, heart rate variability, lipids, glucoseScienceQRUActa Biomedica Scientifica, Vol 6, Iss 1, Pp 7-12 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	threatening preterm labor, obesity, hexoprenaline, heart rate variability, lipids, glucose Science Q
spellingShingle	threatening preterm labor, obesity, hexoprenaline, heart rate variability, lipids, glucose Science Q L. V. Gureeva O. M. Chistyakova E. K. Paramonova O. V. Radkov Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women
description	Background. Obesity is associated with the risk of spontaneous preterm birth. Hexoprenaline is the effective and most widely used tocolytic agent, possessing however a significant number of side effects. The effect of hexoprenaline tocolysis on heart rate variability, lipid spectrum and glycaemia level in obese pregnant women remain unexplored.Aim of the research. To study the effect of tocolytic therapy with hexoprenaline on heart rate variability, lipid spectrum and glycemic level in obese pregnant women.Materials and methods. The study included two groups of pregnant women with threatened preterm labor who received tocolysis with hexoprenaline. One group consisted of 68 obese patients, the other – 72 non-obese pregnant women (control group). Patients underwent Holter monitoring. Fasting serum glucose and lipids spectrum were measured before starting tocolytic therapy and after 24 hours of tocolysis.Results. In obese pregnant women with hexoprenaline infusion, the heart rate, the 24-hours number of supraventricular extrasystoles and ventricular extrasystoles during the day are significantly higher. Frequency domain parameters, very low frequency during the day, low frequency at night and 24-hours high frequency were significantly decreased than in control group. After a day of tocolysis in obese pregnant women, the level of total cholesterol, low density lipoproteins, triglycerides, and glucose significantly increases when compared with the results before therapy. For patients in the control group treated with hexoprenaline, only the concentration of high-density lipoproteins is increased.Conclusion. Obesity in pregnant women receiving hexoprenaline tocolysis is associated with low heart rate variability and an increase in the number of cardiac arrhythmias, as well as lipid disorders and an increase in glucose level.
format	article
author	L. V. Gureeva O. M. Chistyakova E. K. Paramonova O. V. Radkov
author_facet	L. V. Gureeva O. M. Chistyakova E. K. Paramonova O. V. Radkov
author_sort	L. V. Gureeva
title	Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women
title_short	Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women
title_full	Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women
title_fullStr	Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women
title_full_unstemmed	Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women
title_sort	influence of tocolytic therapy with hexoprenaline on heart rate variability, lipid spectrum and glycemic level in obese pregnant women
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/36bea93db46f495887017ca233206076
work_keys_str_mv	AT lvgureeva influenceoftocolytictherapywithhexoprenalineonheartratevariabilitylipidspectrumandglycemiclevelinobesepregnantwomen AT omchistyakova influenceoftocolytictherapywithhexoprenalineonheartratevariabilitylipidspectrumandglycemiclevelinobesepregnantwomen AT ekparamonova influenceoftocolytictherapywithhexoprenalineonheartratevariabilitylipidspectrumandglycemiclevelinobesepregnantwomen AT ovradkov influenceoftocolytictherapywithhexoprenalineonheartratevariabilitylipidspectrumandglycemiclevelinobesepregnantwomen
_version_	1718416875329683456

Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women

Ejemplares similares