Altered visual cortical processing in a mouse model of MECP2 duplication syndrome

Abstract As an epigenetic modulator of gene expression, Methyl-CpG binding protein 2 (MeCP2) is essential for normal neurological function. Dysfunction of MeCP2 is associated with a variety of neurological disorders. MECP2 gene duplication in human causes neuropsychiatric symptoms such as mental ret...

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Autores principales:	Dinghong Zhang, Bin Yu, Jing Liu, Weiqian Jiang, Taorong Xie, Ran Zhang, Dali Tong, Zilong Qiu, Haishan Yao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/36c0543bfd344114b1b57f7976353692
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spelling	oai:doaj.org-article:36c0543bfd344114b1b57f79763536922021-12-02T11:40:23ZAltered visual cortical processing in a mouse model of MECP2 duplication syndrome10.1038/s41598-017-06916-32045-2322https://doaj.org/article/36c0543bfd344114b1b57f79763536922017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06916-3https://doaj.org/toc/2045-2322Abstract As an epigenetic modulator of gene expression, Methyl-CpG binding protein 2 (MeCP2) is essential for normal neurological function. Dysfunction of MeCP2 is associated with a variety of neurological disorders. MECP2 gene duplication in human causes neuropsychiatric symptoms such as mental retardation and autism. MeCP2 overexpression in mice results in neurobehavioural disorders, dendritic abnormalities, and synaptic defects. However, how gain of MeCP2 function influences cortical processing of sensory information remains unclear. In this study, we examined visual processing in a mouse model of MECP2 duplication syndrome (MECP2 Tg1 mouse) at 8 and 14 weeks, which were before and after the onset of behavioural symptoms, respectively. In vivo extracellular recordings from primary visual cortex (V1) showed that neurons in Tg1 mice at both adult ages preferred higher spatial frequencies (SFs) than those in wild-type (WT) littermate controls, and the semi-saturation contrasts of neurons were lower in Tg1 mice at 8 weeks but not at 14 weeks. Behavioural experiments showed that the performance for visual detection at high SFs and low contrasts was higher in MECP2 Tg1 mice. Thus, MeCP2 gain-of-function in mice leads to higher visual acuity and contrast sensitivity, both at the levels of cortical response and behavioural performance.Dinghong ZhangBin YuJing LiuWeiqian JiangTaorong XieRan ZhangDali TongZilong QiuHaishan YaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dinghong Zhang Bin Yu Jing Liu Weiqian Jiang Taorong Xie Ran Zhang Dali Tong Zilong Qiu Haishan Yao Altered visual cortical processing in a mouse model of MECP2 duplication syndrome
description	Abstract As an epigenetic modulator of gene expression, Methyl-CpG binding protein 2 (MeCP2) is essential for normal neurological function. Dysfunction of MeCP2 is associated with a variety of neurological disorders. MECP2 gene duplication in human causes neuropsychiatric symptoms such as mental retardation and autism. MeCP2 overexpression in mice results in neurobehavioural disorders, dendritic abnormalities, and synaptic defects. However, how gain of MeCP2 function influences cortical processing of sensory information remains unclear. In this study, we examined visual processing in a mouse model of MECP2 duplication syndrome (MECP2 Tg1 mouse) at 8 and 14 weeks, which were before and after the onset of behavioural symptoms, respectively. In vivo extracellular recordings from primary visual cortex (V1) showed that neurons in Tg1 mice at both adult ages preferred higher spatial frequencies (SFs) than those in wild-type (WT) littermate controls, and the semi-saturation contrasts of neurons were lower in Tg1 mice at 8 weeks but not at 14 weeks. Behavioural experiments showed that the performance for visual detection at high SFs and low contrasts was higher in MECP2 Tg1 mice. Thus, MeCP2 gain-of-function in mice leads to higher visual acuity and contrast sensitivity, both at the levels of cortical response and behavioural performance.
format	article
author	Dinghong Zhang Bin Yu Jing Liu Weiqian Jiang Taorong Xie Ran Zhang Dali Tong Zilong Qiu Haishan Yao
author_facet	Dinghong Zhang Bin Yu Jing Liu Weiqian Jiang Taorong Xie Ran Zhang Dali Tong Zilong Qiu Haishan Yao
author_sort	Dinghong Zhang
title	Altered visual cortical processing in a mouse model of MECP2 duplication syndrome
title_short	Altered visual cortical processing in a mouse model of MECP2 duplication syndrome
title_full	Altered visual cortical processing in a mouse model of MECP2 duplication syndrome
title_fullStr	Altered visual cortical processing in a mouse model of MECP2 duplication syndrome
title_full_unstemmed	Altered visual cortical processing in a mouse model of MECP2 duplication syndrome
title_sort	altered visual cortical processing in a mouse model of mecp2 duplication syndrome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/36c0543bfd344114b1b57f7976353692
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Altered visual cortical processing in a mouse model of MECP2 duplication syndrome

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