Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease

Alexander disease is a rare neurodegeneration caused by mutations in a glial gene GFAP. Here, Wang and colleagues show in animal models of Alexander disease that GFAP mutant brain and cells have greater tissue and cellular stiffness and greater activation of mechanosensitive signaling cascade.

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Autores principales:	Liqun Wang, Jing Xia, Jonathan Li, Tracy L. Hagemann, Jeffrey R. Jones, Ernest Fraenkel, David A. Weitz, Su-Chun Zhang, Albee Messing, Mel B. Feany
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36c12df858ac434183e838e24dc960c5
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spelling	oai:doaj.org-article:36c12df858ac434183e838e24dc960c52021-12-02T17:31:30ZTissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease10.1038/s41467-018-04269-72041-1723https://doaj.org/article/36c12df858ac434183e838e24dc960c52018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04269-7https://doaj.org/toc/2041-1723Alexander disease is a rare neurodegeneration caused by mutations in a glial gene GFAP. Here, Wang and colleagues show in animal models of Alexander disease that GFAP mutant brain and cells have greater tissue and cellular stiffness and greater activation of mechanosensitive signaling cascade.Liqun WangJing XiaJonathan LiTracy L. HagemannJeffrey R. JonesErnest FraenkelDavid A. WeitzSu-Chun ZhangAlbee MessingMel B. FeanyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liqun Wang Jing Xia Jonathan Li Tracy L. Hagemann Jeffrey R. Jones Ernest Fraenkel David A. Weitz Su-Chun Zhang Albee Messing Mel B. Feany Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease
description	Alexander disease is a rare neurodegeneration caused by mutations in a glial gene GFAP. Here, Wang and colleagues show in animal models of Alexander disease that GFAP mutant brain and cells have greater tissue and cellular stiffness and greater activation of mechanosensitive signaling cascade.
format	article
author	Liqun Wang Jing Xia Jonathan Li Tracy L. Hagemann Jeffrey R. Jones Ernest Fraenkel David A. Weitz Su-Chun Zhang Albee Messing Mel B. Feany
author_facet	Liqun Wang Jing Xia Jonathan Li Tracy L. Hagemann Jeffrey R. Jones Ernest Fraenkel David A. Weitz Su-Chun Zhang Albee Messing Mel B. Feany
author_sort	Liqun Wang
title	Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease
title_short	Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease
title_full	Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease
title_fullStr	Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease
title_full_unstemmed	Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease
title_sort	tissue and cellular rigidity and mechanosensitive signaling activation in alexander disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/36c12df858ac434183e838e24dc960c5
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Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease

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