A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes

Convenient and fast methods to introduce 11C into organic molecules are of great help for molecular imaging studies. Here, the authors developed an efficient incorporation of [11C]CO2 and [11C]CH3I into molecules via a fluoride-mediated desilylation process.

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Autores principales:	Wenchao Qu, Bao Hu, John W. Babich, Nicole Waterhouse, Marybeth Dooley, Shashikanth Ponnala, Julie Urgiles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36c86449efb34b8ea72c8e66f8f2890f
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spelling	oai:doaj.org-article:36c86449efb34b8ea72c8e66f8f2890f2021-12-02T14:41:23ZA general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes10.1038/s41467-020-15556-72041-1723https://doaj.org/article/36c86449efb34b8ea72c8e66f8f2890f2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15556-7https://doaj.org/toc/2041-1723Convenient and fast methods to introduce 11C into organic molecules are of great help for molecular imaging studies. Here, the authors developed an efficient incorporation of [11C]CO2 and [11C]CH3I into molecules via a fluoride-mediated desilylation process.Wenchao QuBao HuJohn W. BabichNicole WaterhouseMarybeth DooleyShashikanth PonnalaJulie UrgilesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenchao Qu Bao Hu John W. Babich Nicole Waterhouse Marybeth Dooley Shashikanth Ponnala Julie Urgiles A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes
description	Convenient and fast methods to introduce 11C into organic molecules are of great help for molecular imaging studies. Here, the authors developed an efficient incorporation of [11C]CO2 and [11C]CH3I into molecules via a fluoride-mediated desilylation process.
format	article
author	Wenchao Qu Bao Hu John W. Babich Nicole Waterhouse Marybeth Dooley Shashikanth Ponnala Julie Urgiles
author_facet	Wenchao Qu Bao Hu John W. Babich Nicole Waterhouse Marybeth Dooley Shashikanth Ponnala Julie Urgiles
author_sort	Wenchao Qu
title	A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes
title_short	A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes
title_full	A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes
title_fullStr	A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes
title_full_unstemmed	A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes
title_sort	general 11c-labeling approach enabled by fluoride-mediated desilylation of organosilanes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/36c86449efb34b8ea72c8e66f8f2890f
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A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes

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