Clinical significance of matrix metalloproteinase (MMP)-2 and MMP-9 expression in laryngeal squamous cell carcinoma

Background/Aim. The previous researches suggest that matrix metalloproteinases (MMPs) have the ability to degrade extracellu-lar matrix components and play an important role in malignant tumour progression and metastasis. The aim of this study was to investigate MMP-2 and MMP-9 expression in the tis...

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Autores principales:	Rašić Dejan, Perić Aleksandar, Vukomanović-Đurđević Biserka, Sotirović Jelena, Baletić Nenad, Milojević Milanko, Pavićević Ljubomir, Dimić Aleksandar
Formato:	article
Lenguaje:	EN SR
Publicado:	Military Health Department, Ministry of Defance, Serbia 2021
Materias:	biomarkers glottis immunohistochemistry larynx, neoplasms laryngitis matrix metalloproteinases Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/36c8b3f7b98141dea5d9a32e61758881
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spelling	oai:doaj.org-article:36c8b3f7b98141dea5d9a32e617588812021-11-10T07:27:57ZClinical significance of matrix metalloproteinase (MMP)-2 and MMP-9 expression in laryngeal squamous cell carcinoma0042-84502406-072010.2298/VSP191223015Rhttps://doaj.org/article/36c8b3f7b98141dea5d9a32e617588812021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000015R.pdfhttps://doaj.org/toc/0042-8450https://doaj.org/toc/2406-0720Background/Aim. The previous researches suggest that matrix metalloproteinases (MMPs) have the ability to degrade extracellu-lar matrix components and play an important role in malignant tumour progression and metastasis. The aim of this study was to investigate MMP-2 and MMP-9 expression in the tissue of laryn-geal squamous cell carcinoma (LSCC) and to evaluate their clini-cal significance. Methods. In this prospective study the samples of tumour tissue of seventy patients with LSCC (45 glottic and 25 supraglottic), and samples of laryngeal mucosa of 70 patients with chronic laryngitis were immunohistochemically stained for MMP-2 and MMP-9. We studied the relationships between MMPs tissue expression and clinical and histological characteris-tics of the patients with LSCC in comparison to the patients with chronic laryngitis. Results. MMP-2 and MMP-9 expression was significantly higher in the tissue of both glottic and supraglottic LSCC than in chronically inflamed laryngeal mucosa (p < 0.001 and p < 0.001, respectively). There were positive correlations be-tween epithelial MMP-2 expression and the presence of perineu-ral invasion (r = 0.515, p < 0.008), lymphovascular invasion (r = 0.559, p < 0.004) and disease recurrence (r = 0.415, p < 0.039) in supraglottic LSCC, as well as between MMP-2 expression and the presence of the exophytic type of tumour growth (r = 0.347, p < 0.020) in glottic LSCC. Epithelial MMP-9 expression was as-sociated with lymphovascular invasion (r = 0.331, p < 0.026) and the presence of the exophytic tumour growth (r = 0.474, p < 0.001) in glottic LSCC. Conclusion. MMP-2 and MMP-9 can be used as potential biomarkers for the assessment of LSCC progression.Rašić DejanPerić AleksandarVukomanović-Đurđević BiserkaSotirović JelenaBaletić NenadMilojević MilankoPavićević LjubomirDimić AleksandarMilitary Health Department, Ministry of Defance, Serbiaarticlebiomarkersglottisimmunohistochemistrylarynx, neoplasmslaryngitismatrix metalloproteinasesMedicine (General)R5-920ENSRVojnosanitetski Pregled, Vol 78, Iss 10, Pp 1021-1027 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	biomarkers glottis immunohistochemistry larynx, neoplasms laryngitis matrix metalloproteinases Medicine (General) R5-920
spellingShingle	biomarkers glottis immunohistochemistry larynx, neoplasms laryngitis matrix metalloproteinases Medicine (General) R5-920 Rašić Dejan Perić Aleksandar Vukomanović-Đurđević Biserka Sotirović Jelena Baletić Nenad Milojević Milanko Pavićević Ljubomir Dimić Aleksandar Clinical significance of matrix metalloproteinase (MMP)-2 and MMP-9 expression in laryngeal squamous cell carcinoma
description	Background/Aim. The previous researches suggest that matrix metalloproteinases (MMPs) have the ability to degrade extracellu-lar matrix components and play an important role in malignant tumour progression and metastasis. The aim of this study was to investigate MMP-2 and MMP-9 expression in the tissue of laryn-geal squamous cell carcinoma (LSCC) and to evaluate their clini-cal significance. Methods. In this prospective study the samples of tumour tissue of seventy patients with LSCC (45 glottic and 25 supraglottic), and samples of laryngeal mucosa of 70 patients with chronic laryngitis were immunohistochemically stained for MMP-2 and MMP-9. We studied the relationships between MMPs tissue expression and clinical and histological characteris-tics of the patients with LSCC in comparison to the patients with chronic laryngitis. Results. MMP-2 and MMP-9 expression was significantly higher in the tissue of both glottic and supraglottic LSCC than in chronically inflamed laryngeal mucosa (p < 0.001 and p < 0.001, respectively). There were positive correlations be-tween epithelial MMP-2 expression and the presence of perineu-ral invasion (r = 0.515, p < 0.008), lymphovascular invasion (r = 0.559, p < 0.004) and disease recurrence (r = 0.415, p < 0.039) in supraglottic LSCC, as well as between MMP-2 expression and the presence of the exophytic type of tumour growth (r = 0.347, p < 0.020) in glottic LSCC. Epithelial MMP-9 expression was as-sociated with lymphovascular invasion (r = 0.331, p < 0.026) and the presence of the exophytic tumour growth (r = 0.474, p < 0.001) in glottic LSCC. Conclusion. MMP-2 and MMP-9 can be used as potential biomarkers for the assessment of LSCC progression.
format	article
author	Rašić Dejan Perić Aleksandar Vukomanović-Đurđević Biserka Sotirović Jelena Baletić Nenad Milojević Milanko Pavićević Ljubomir Dimić Aleksandar
author_facet	Rašić Dejan Perić Aleksandar Vukomanović-Đurđević Biserka Sotirović Jelena Baletić Nenad Milojević Milanko Pavićević Ljubomir Dimić Aleksandar
author_sort	Rašić Dejan
title	Clinical significance of matrix metalloproteinase (MMP)-2 and MMP-9 expression in laryngeal squamous cell carcinoma
title_short	Clinical significance of matrix metalloproteinase (MMP)-2 and MMP-9 expression in laryngeal squamous cell carcinoma
title_full	Clinical significance of matrix metalloproteinase (MMP)-2 and MMP-9 expression in laryngeal squamous cell carcinoma
title_fullStr	Clinical significance of matrix metalloproteinase (MMP)-2 and MMP-9 expression in laryngeal squamous cell carcinoma
title_full_unstemmed	Clinical significance of matrix metalloproteinase (MMP)-2 and MMP-9 expression in laryngeal squamous cell carcinoma
title_sort	clinical significance of matrix metalloproteinase (mmp)-2 and mmp-9 expression in laryngeal squamous cell carcinoma
publisher	Military Health Department, Ministry of Defance, Serbia
publishDate	2021
url	https://doaj.org/article/36c8b3f7b98141dea5d9a32e61758881
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Clinical significance of matrix metalloproteinase (MMP)-2 and MMP-9 expression in laryngeal squamous cell carcinoma

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