Fourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm’s Canal of Nonglaucomatous Subjects After Keratoplasty

Purpose: This study aimed to evaluate the impact of keratoplasty on the in vivo anatomical structures in the Schlemm’s canal (SC) of nonglaucomatous subjects using Fourier-domain optical coherence tomography (FD-OCT).Methods: Sixty-six nonglaucomatous eyes that underwent penetrating keratoplasty (PK...

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Autores principales:	Yujin Zhao, Yue Li, Jiaxu Hong, Qihua Le, Jianjiang Xu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cornea keratoplasty Schlemm’s canal (SC) Fourier domain optical coherence tomography (FD-OCT) in vivo imaging Physiology QP1-981
Acceso en línea:	https://doaj.org/article/36c954820eeb42a4a97eb12e61febbf8
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spelling	oai:doaj.org-article:36c954820eeb42a4a97eb12e61febbf82021-12-02T10:50:31ZFourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm’s Canal of Nonglaucomatous Subjects After Keratoplasty1664-042X10.3389/fphys.2021.716117https://doaj.org/article/36c954820eeb42a4a97eb12e61febbf82021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.716117/fullhttps://doaj.org/toc/1664-042XPurpose: This study aimed to evaluate the impact of keratoplasty on the in vivo anatomical structures in the Schlemm’s canal (SC) of nonglaucomatous subjects using Fourier-domain optical coherence tomography (FD-OCT).Methods: Sixty-six nonglaucomatous eyes that underwent penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), or triple surgery were enrolled in this prospective, comparative, observational study. The SC imaging was performed using FD-OCT before and after surgery in both the nasal and temporal quadrants. Patient demographics, SC parameters [e.g., cross-sectional area (CSA), meridional diameter of SC (MSC), sagittal diameter of SC (SSC), and circumference (CCF)], and the correlations between the variation of SC parameters and intraocular pressure (IOP) were analyzed.Results: The mean age of all subjects was 40.27 ± 18.97 years. Among all cases, the nasal, temporal, and mean MSC significantly decreased on the first day after surgery and then increased at 1 week (p = 0.04, 0.017, and 0.01, respectively). Temporal CSA (tCSA), temporal MSC (tMSC), and temporal circumference (tCCF) after PK (p = 0.017, 0.020, and 0.018, respectively) and nasal MSC (nMSC) after DALK (p = 0.025) decreased significantly on the first day after surgery. The shift in mean IOP was significantly correlated with the changes in tMSC (r = 0.341, p = 0.003) and CCF (r = 0.207, p = 0.048).Conclusion: SC had significant in vivo morphological changes in the early period after keratoplasty in nonglaucomatous eyes, accompanied with elevation of IOP. Early intervention might be necessary to prevent secondary glaucoma early after keratoplasty.Yujin ZhaoYujin ZhaoYue LiYue LiJiaxu HongJiaxu HongJiaxu HongQihua LeQihua LeJianjiang XuJianjiang XuFrontiers Media S.A.articlecorneakeratoplastySchlemm’s canal (SC)Fourier domain optical coherence tomography (FD-OCT)in vivo imagingPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cornea keratoplasty Schlemm’s canal (SC) Fourier domain optical coherence tomography (FD-OCT) in vivo imaging Physiology QP1-981
spellingShingle	cornea keratoplasty Schlemm’s canal (SC) Fourier domain optical coherence tomography (FD-OCT) in vivo imaging Physiology QP1-981 Yujin Zhao Yujin Zhao Yue Li Yue Li Jiaxu Hong Jiaxu Hong Jiaxu Hong Qihua Le Qihua Le Jianjiang Xu Jianjiang Xu Fourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm’s Canal of Nonglaucomatous Subjects After Keratoplasty
description	Purpose: This study aimed to evaluate the impact of keratoplasty on the in vivo anatomical structures in the Schlemm’s canal (SC) of nonglaucomatous subjects using Fourier-domain optical coherence tomography (FD-OCT).Methods: Sixty-six nonglaucomatous eyes that underwent penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), or triple surgery were enrolled in this prospective, comparative, observational study. The SC imaging was performed using FD-OCT before and after surgery in both the nasal and temporal quadrants. Patient demographics, SC parameters [e.g., cross-sectional area (CSA), meridional diameter of SC (MSC), sagittal diameter of SC (SSC), and circumference (CCF)], and the correlations between the variation of SC parameters and intraocular pressure (IOP) were analyzed.Results: The mean age of all subjects was 40.27 ± 18.97 years. Among all cases, the nasal, temporal, and mean MSC significantly decreased on the first day after surgery and then increased at 1 week (p = 0.04, 0.017, and 0.01, respectively). Temporal CSA (tCSA), temporal MSC (tMSC), and temporal circumference (tCCF) after PK (p = 0.017, 0.020, and 0.018, respectively) and nasal MSC (nMSC) after DALK (p = 0.025) decreased significantly on the first day after surgery. The shift in mean IOP was significantly correlated with the changes in tMSC (r = 0.341, p = 0.003) and CCF (r = 0.207, p = 0.048).Conclusion: SC had significant in vivo morphological changes in the early period after keratoplasty in nonglaucomatous eyes, accompanied with elevation of IOP. Early intervention might be necessary to prevent secondary glaucoma early after keratoplasty.
format	article
author	Yujin Zhao Yujin Zhao Yue Li Yue Li Jiaxu Hong Jiaxu Hong Jiaxu Hong Qihua Le Qihua Le Jianjiang Xu Jianjiang Xu
author_facet	Yujin Zhao Yujin Zhao Yue Li Yue Li Jiaxu Hong Jiaxu Hong Jiaxu Hong Qihua Le Qihua Le Jianjiang Xu Jianjiang Xu
author_sort	Yujin Zhao
title	Fourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm’s Canal of Nonglaucomatous Subjects After Keratoplasty
title_short	Fourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm’s Canal of Nonglaucomatous Subjects After Keratoplasty
title_full	Fourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm’s Canal of Nonglaucomatous Subjects After Keratoplasty
title_fullStr	Fourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm’s Canal of Nonglaucomatous Subjects After Keratoplasty
title_full_unstemmed	Fourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm’s Canal of Nonglaucomatous Subjects After Keratoplasty
title_sort	fourier-domain optical coherence tomographic assessment of changes in the schlemm’s canal of nonglaucomatous subjects after keratoplasty
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/36c954820eeb42a4a97eb12e61febbf8
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Fourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm’s Canal of Nonglaucomatous Subjects After Keratoplasty

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