Evaluation of Panbio rapid antigen test for SARS‐CoV‐2 in symptomatic patients and their contacts: a multicenter study
Background: Point-of-care rapid tests to identify SARS-CoV-2 can have clinical benefits. Methods: A cross-sectional study in adults visiting emergency services or screening sites of referral hospitals for COVID-19 to validate the diagnostic performance of a rapid antigen test for SARS-CoV-2 (Abbott&...
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2021
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oai:doaj.org-article:36c9ec7fdecf47a98ba2299bde37eda22021-11-12T04:27:21ZEvaluation of Panbio rapid antigen test for SARS‐CoV‐2 in symptomatic patients and their contacts: a multicenter study1201-971210.1016/j.ijid.2021.10.027https://doaj.org/article/36c9ec7fdecf47a98ba2299bde37eda22021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008110https://doaj.org/toc/1201-9712Background: Point-of-care rapid tests to identify SARS-CoV-2 can have clinical benefits. Methods: A cross-sectional study in adults visiting emergency services or screening sites of referral hospitals for COVID-19 to validate the diagnostic performance of a rapid antigen test for SARS-CoV-2 (Abbott's Panbio) compared with reverse transcription-polymerase chain reaction (RT-PCR) testing. Tests were performed by health personnel in a routine situation during a COVID-19 outbreak. Results: A total of 1060 participants (mean age 47, 46% with a self-reported comorbidity) were recruited from 8 hospitals in Mexico. Participants provided 1060 valid Panbio rapid test-RT-PCR test pairs with 45% testing positive in the RT-PCR. Overall sensitivity of the Panbio test was 54.2% (95% CI 51%–57%), and 69.1% (95% CI 66%–73%) for patients during the first week of symptoms. Sensitivity depended on viral load (cycle threshold (Ct) of RT-PCR) and days of symptoms. With a Ct ≤25, sensitivity was 82% (95% CI, 76%–87%). Specificity of the Panbio test was >97.8% in all groups. Conclusions: The Panbio rapid antigen test for SARS-CoV-2 had good specificity but low sensitivity. A negative test requires confirmation with RT-PCR, especially for testing after the first week of symptoms.Ireri Thirion-RomeroDr. Selene Guerrero-ZúñigaDr. Alexandra Arias-MendozaDr. Dora Patricia Cornejo-JuárezDr. Patricia Meza-MenesesDr. Darwin Stalin Torres-ErazoDr. Thierry Hernández-GilsoulDr. Arturo Galindo-FragaDr. Isabel Villegas-MotaDr. Jesús Sepúlveda-DelgadoDr. Santiago Ávila-RíosDr. Eduardo Becerril-VargasRosario Fernández-PlataTIT Midori Pérez-KawabeDr. Ana Coeto-CanoDr. Joel Armando Vázquez-PérezDr. Simón Kawa-KarasikDr. Gustavo Reyes-TeránDr. José Rogelio Pérez-PadillaElsevierarticleCOVID-19SARS-CoV-2point of care testrapid antigen testPanbioAbbottInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 218-224 (2021) |
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DOAJ |
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DOAJ |
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COVID-19 SARS-CoV-2 point of care test rapid antigen test Panbio Abbott Infectious and parasitic diseases RC109-216 |
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COVID-19 SARS-CoV-2 point of care test rapid antigen test Panbio Abbott Infectious and parasitic diseases RC109-216 Ireri Thirion-Romero Dr. Selene Guerrero-Zúñiga Dr. Alexandra Arias-Mendoza Dr. Dora Patricia Cornejo-Juárez Dr. Patricia Meza-Meneses Dr. Darwin Stalin Torres-Erazo Dr. Thierry Hernández-Gilsoul Dr. Arturo Galindo-Fraga Dr. Isabel Villegas-Mota Dr. Jesús Sepúlveda-Delgado Dr. Santiago Ávila-Ríos Dr. Eduardo Becerril-Vargas Rosario Fernández-Plata TIT Midori Pérez-Kawabe Dr. Ana Coeto-Cano Dr. Joel Armando Vázquez-Pérez Dr. Simón Kawa-Karasik Dr. Gustavo Reyes-Terán Dr. José Rogelio Pérez-Padilla Evaluation of Panbio rapid antigen test for SARS‐CoV‐2 in symptomatic patients and their contacts: a multicenter study |
| description |
Background: Point-of-care rapid tests to identify SARS-CoV-2 can have clinical benefits. Methods: A cross-sectional study in adults visiting emergency services or screening sites of referral hospitals for COVID-19 to validate the diagnostic performance of a rapid antigen test for SARS-CoV-2 (Abbott's Panbio) compared with reverse transcription-polymerase chain reaction (RT-PCR) testing. Tests were performed by health personnel in a routine situation during a COVID-19 outbreak. Results: A total of 1060 participants (mean age 47, 46% with a self-reported comorbidity) were recruited from 8 hospitals in Mexico. Participants provided 1060 valid Panbio rapid test-RT-PCR test pairs with 45% testing positive in the RT-PCR. Overall sensitivity of the Panbio test was 54.2% (95% CI 51%–57%), and 69.1% (95% CI 66%–73%) for patients during the first week of symptoms. Sensitivity depended on viral load (cycle threshold (Ct) of RT-PCR) and days of symptoms. With a Ct ≤25, sensitivity was 82% (95% CI, 76%–87%). Specificity of the Panbio test was >97.8% in all groups. Conclusions: The Panbio rapid antigen test for SARS-CoV-2 had good specificity but low sensitivity. A negative test requires confirmation with RT-PCR, especially for testing after the first week of symptoms. |
| format |
article |
| author |
Ireri Thirion-Romero Dr. Selene Guerrero-Zúñiga Dr. Alexandra Arias-Mendoza Dr. Dora Patricia Cornejo-Juárez Dr. Patricia Meza-Meneses Dr. Darwin Stalin Torres-Erazo Dr. Thierry Hernández-Gilsoul Dr. Arturo Galindo-Fraga Dr. Isabel Villegas-Mota Dr. Jesús Sepúlveda-Delgado Dr. Santiago Ávila-Ríos Dr. Eduardo Becerril-Vargas Rosario Fernández-Plata TIT Midori Pérez-Kawabe Dr. Ana Coeto-Cano Dr. Joel Armando Vázquez-Pérez Dr. Simón Kawa-Karasik Dr. Gustavo Reyes-Terán Dr. José Rogelio Pérez-Padilla |
| author_facet |
Ireri Thirion-Romero Dr. Selene Guerrero-Zúñiga Dr. Alexandra Arias-Mendoza Dr. Dora Patricia Cornejo-Juárez Dr. Patricia Meza-Meneses Dr. Darwin Stalin Torres-Erazo Dr. Thierry Hernández-Gilsoul Dr. Arturo Galindo-Fraga Dr. Isabel Villegas-Mota Dr. Jesús Sepúlveda-Delgado Dr. Santiago Ávila-Ríos Dr. Eduardo Becerril-Vargas Rosario Fernández-Plata TIT Midori Pérez-Kawabe Dr. Ana Coeto-Cano Dr. Joel Armando Vázquez-Pérez Dr. Simón Kawa-Karasik Dr. Gustavo Reyes-Terán Dr. José Rogelio Pérez-Padilla |
| author_sort |
Ireri Thirion-Romero |
| title |
Evaluation of Panbio rapid antigen test for SARS‐CoV‐2 in symptomatic patients and their contacts: a multicenter study |
| title_short |
Evaluation of Panbio rapid antigen test for SARS‐CoV‐2 in symptomatic patients and their contacts: a multicenter study |
| title_full |
Evaluation of Panbio rapid antigen test for SARS‐CoV‐2 in symptomatic patients and their contacts: a multicenter study |
| title_fullStr |
Evaluation of Panbio rapid antigen test for SARS‐CoV‐2 in symptomatic patients and their contacts: a multicenter study |
| title_full_unstemmed |
Evaluation of Panbio rapid antigen test for SARS‐CoV‐2 in symptomatic patients and their contacts: a multicenter study |
| title_sort |
evaluation of panbio rapid antigen test for sars‐cov‐2 in symptomatic patients and their contacts: a multicenter study |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/36c9ec7fdecf47a98ba2299bde37eda2 |
| work_keys_str_mv |
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