Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits

Keisuke Noto,1 Akihito Suzuki,1 Toshinori Shirata,1 Yoshihiko Matsumoto,1 Nana Takahashi,1 Kaoru Goto,2 Koichi Otani1 1Department of Psychiatry, Yamagata University School of Medicine, Yamagata 990-9585, Japan; 2Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata...

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Autores principales:	Noto K, Suzuki A, Shirata T, Matsumoto Y, Takahashi N, Goto K, Otani K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	oprm1 attachment personality pbi tci gene-environment interaction. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/36cff9993077410bb95c2855362da318
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spelling	oai:doaj.org-article:36cff9993077410bb95c2855362da3182021-12-02T08:55:54ZMu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits1178-2021https://doaj.org/article/36cff9993077410bb95c2855362da3182020-09-01T00:00:00Zhttps://www.dovepress.com/mu-opioid-receptor-polymorphism-moderates-sensitivity-to-parental-beha-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Keisuke Noto,1 Akihito Suzuki,1 Toshinori Shirata,1 Yoshihiko Matsumoto,1 Nana Takahashi,1 Kaoru Goto,2 Koichi Otani1 1Department of Psychiatry, Yamagata University School of Medicine, Yamagata 990-9585, Japan; 2Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990-9585, JapanCorrespondence: Toshinori Shirata Email white_gregory000@yahoo.co.jpPurpose: Attachment research shows that attachment experiences with parents in childhood influence the characterization of personality traits. Meanwhile, it is known that mu-opioid receptor function is involved in human attachment. Furthermore, a few studies suggest that the A118G polymorphism of the mu-opioid receptor gene (OPRM1) is associated with altered mu-opioid receptor function. Thus, we examined if the OPRM1 polymorphism moderates the sensitivity to parental behaviors and thereby contributes to the characterization of personality traits.Materials and Methods: Participants were 725 healthy Japanese. Parenting practices of their parents were evaluated by the Parental Bonding Instrument (PBI) with the care and protection subscales. Personality was evaluated using the Temperament and Character Inventory (TCI). The OPRM1 A118G polymorphism was detected by a PCR method.Results: Multiple regression analyses revealed significant effects of the interaction between the OPRM1 genotype and maternal protection on scores of the self-directedness and cooperativeness dimensions, while significant main effects of the OPRM1 genotype on scores of the TCI were not found. Further analyses showed that there were significant negative correlations between maternal protection scores and the two dimensional scores in the A/A and A/G genotypes with higher correlation coefficients in the former, but not in the G/G genotype.Conclusion: The present study suggests that the OPRM1 polymorphism contributes to the characterization of personality traits by moderating the sensitivity to parental behaviors, especially maternal protection.Keywords: OPRM1, attachment, personality, PBI, TCI, gene–environment interactionNoto KSuzuki AShirata TMatsumoto YTakahashi NGoto KOtani KDove Medical Pressarticleoprm1attachmentpersonalitypbitcigene-environment interaction.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2161-2167 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	oprm1 attachment personality pbi tci gene-environment interaction. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	oprm1 attachment personality pbi tci gene-environment interaction. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Noto K Suzuki A Shirata T Matsumoto Y Takahashi N Goto K Otani K Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits
description	Keisuke Noto,1 Akihito Suzuki,1 Toshinori Shirata,1 Yoshihiko Matsumoto,1 Nana Takahashi,1 Kaoru Goto,2 Koichi Otani1 1Department of Psychiatry, Yamagata University School of Medicine, Yamagata 990-9585, Japan; 2Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990-9585, JapanCorrespondence: Toshinori Shirata Email white_gregory000@yahoo.co.jpPurpose: Attachment research shows that attachment experiences with parents in childhood influence the characterization of personality traits. Meanwhile, it is known that mu-opioid receptor function is involved in human attachment. Furthermore, a few studies suggest that the A118G polymorphism of the mu-opioid receptor gene (OPRM1) is associated with altered mu-opioid receptor function. Thus, we examined if the OPRM1 polymorphism moderates the sensitivity to parental behaviors and thereby contributes to the characterization of personality traits.Materials and Methods: Participants were 725 healthy Japanese. Parenting practices of their parents were evaluated by the Parental Bonding Instrument (PBI) with the care and protection subscales. Personality was evaluated using the Temperament and Character Inventory (TCI). The OPRM1 A118G polymorphism was detected by a PCR method.Results: Multiple regression analyses revealed significant effects of the interaction between the OPRM1 genotype and maternal protection on scores of the self-directedness and cooperativeness dimensions, while significant main effects of the OPRM1 genotype on scores of the TCI were not found. Further analyses showed that there were significant negative correlations between maternal protection scores and the two dimensional scores in the A/A and A/G genotypes with higher correlation coefficients in the former, but not in the G/G genotype.Conclusion: The present study suggests that the OPRM1 polymorphism contributes to the characterization of personality traits by moderating the sensitivity to parental behaviors, especially maternal protection.Keywords: OPRM1, attachment, personality, PBI, TCI, gene–environment interaction
format	article
author	Noto K Suzuki A Shirata T Matsumoto Y Takahashi N Goto K Otani K
author_facet	Noto K Suzuki A Shirata T Matsumoto Y Takahashi N Goto K Otani K
author_sort	Noto K
title	Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits
title_short	Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits
title_full	Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits
title_fullStr	Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits
title_full_unstemmed	Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits
title_sort	mu-opioid receptor polymorphism moderates sensitivity to parental behaviors during characterization of personality traits
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/36cff9993077410bb95c2855362da318
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Mu-Opioid Receptor Polymorphism Moderates Sensitivity to Parental Behaviors During Characterization of Personality Traits

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