ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells

ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells

Abstract ALK inhibitors effectively target EML4-ALK positive non-small cell lung cancer, but their effects are hampered by treatment resistance. In the present study, we asked whether ALK inhibition affects autophagy, and whether this may influence treatment response. Whereas the impact of targeted...

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Autores principales: Anna M. Schläfli, Igor Tokarchuk, Sarah Parejo, Susanne Jutzi, Sabina Berezowska, Nikolai Engedal, Mario P. Tschan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/36d00b765291419896f093de52d297ab
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