Improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation

Background: Brain stimulation is known to affect canonical pathways and proteins involved in memory. However, there are conflicting results on the ability of brain stimulation to improve to memory, which may be due to variations in timing of stimulation. Hypothesis: We hypothesized that repetitive t...

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Autores principales:	A.M. Heath, M. Brewer, J. Yesavage, M.W. McNerney
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Repetitive transcranial magnetic stimulation Neuromodulation Object recognition memory Synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/36d4dd80627a43ccb2f22e74fbcee84c
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id	oai:doaj.org-article:36d4dd80627a43ccb2f22e74fbcee84c
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spelling	oai:doaj.org-article:36d4dd80627a43ccb2f22e74fbcee84c2021-11-20T05:05:11ZImproved object recognition memory using post-encoding repetitive transcranial magnetic stimulation1935-861X10.1016/j.brs.2021.11.009https://doaj.org/article/36d4dd80627a43ccb2f22e74fbcee84c2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1935861X2100824Xhttps://doaj.org/toc/1935-861XBackground: Brain stimulation is known to affect canonical pathways and proteins involved in memory. However, there are conflicting results on the ability of brain stimulation to improve to memory, which may be due to variations in timing of stimulation. Hypothesis: We hypothesized that repetitive transcranial magnetic stimulation (rTMS) given following a learning task and within the time period before retrieval could help improve memory. Methods: We implanted male B6129SF2/J mice (n = 32) with a cranial attachment to secure the rTMS coil so that the mice could be given consistent stimulation to the frontal area whilst freely moving. Mice then underwent the object recognition test sampling phase and given treatment +3, +24, +48 h following the test. Treatment consisted of 10 min 10 Hz rTMS stimulation (TMS, n = 10), sham treatment (SHAM, n = 11) or a control group which did not do the behavior test or receive rTMS (CONTROL n = 11). At +72 h mice were tested for their exploration of the novel vs familiar object. Results: At 72-h's, only the mice which received rTMS had greater exploration of the novel object than the familiar object. We further show that promoting synaptic GluR2 and maintaining synaptic connections in the perirhinal cortex and hippocampal CA1 are important for this effect. In addition, we found evidence that these changes were linked to CAMKII and CREB pathways in hippocampal neurons. Conclusion: By linking the known biological effects of rTMS to memory pathways we provide evidence that rTMS is effective in improving memory when given during the consolidation and maintenance phases.A.M. HeathM. BrewerJ. YesavageM.W. McNerneyElsevierarticleRepetitive transcranial magnetic stimulationNeuromodulationObject recognition memorySynaptic plasticityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Stimulation, Vol 15, Iss 1, Pp 78-86 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Repetitive transcranial magnetic stimulation Neuromodulation Object recognition memory Synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Repetitive transcranial magnetic stimulation Neuromodulation Object recognition memory Synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 A.M. Heath M. Brewer J. Yesavage M.W. McNerney Improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation
description	Background: Brain stimulation is known to affect canonical pathways and proteins involved in memory. However, there are conflicting results on the ability of brain stimulation to improve to memory, which may be due to variations in timing of stimulation. Hypothesis: We hypothesized that repetitive transcranial magnetic stimulation (rTMS) given following a learning task and within the time period before retrieval could help improve memory. Methods: We implanted male B6129SF2/J mice (n = 32) with a cranial attachment to secure the rTMS coil so that the mice could be given consistent stimulation to the frontal area whilst freely moving. Mice then underwent the object recognition test sampling phase and given treatment +3, +24, +48 h following the test. Treatment consisted of 10 min 10 Hz rTMS stimulation (TMS, n = 10), sham treatment (SHAM, n = 11) or a control group which did not do the behavior test or receive rTMS (CONTROL n = 11). At +72 h mice were tested for their exploration of the novel vs familiar object. Results: At 72-h's, only the mice which received rTMS had greater exploration of the novel object than the familiar object. We further show that promoting synaptic GluR2 and maintaining synaptic connections in the perirhinal cortex and hippocampal CA1 are important for this effect. In addition, we found evidence that these changes were linked to CAMKII and CREB pathways in hippocampal neurons. Conclusion: By linking the known biological effects of rTMS to memory pathways we provide evidence that rTMS is effective in improving memory when given during the consolidation and maintenance phases.
format	article
author	A.M. Heath M. Brewer J. Yesavage M.W. McNerney
author_facet	A.M. Heath M. Brewer J. Yesavage M.W. McNerney
author_sort	A.M. Heath
title	Improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation
title_short	Improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation
title_full	Improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation
title_fullStr	Improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation
title_full_unstemmed	Improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation
title_sort	improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/36d4dd80627a43ccb2f22e74fbcee84c
work_keys_str_mv	AT amheath improvedobjectrecognitionmemoryusingpostencodingrepetitivetranscranialmagneticstimulation AT mbrewer improvedobjectrecognitionmemoryusingpostencodingrepetitivetranscranialmagneticstimulation AT jyesavage improvedobjectrecognitionmemoryusingpostencodingrepetitivetranscranialmagneticstimulation AT mwmcnerney improvedobjectrecognitionmemoryusingpostencodingrepetitivetranscranialmagneticstimulation
_version_	1718419591316635648

Improved object recognition memory using post-encoding repetitive transcranial magnetic stimulation

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