RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network

RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network

Hepatic steatosis development may result from dysregulation of lipid metabolism, which is finely tuned by several transcription factors including the PPAR family. Here Kim et al. show that the nuclear receptor RORα inhibits PPARγ-mediated transcriptional activity by interacting with HDAC3 and compet...

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Autores principales: Kyeongkyu Kim, Kyungjin Boo, Young Suk Yu, Se Kyu Oh, Hyunkyung Kim, Yoon Jeon, Jinhyuk Bhin, Daehee Hwang, Keun Il Kim, Jun-Su Lee, Seung-Soon Im, Seul Gi Yoon, Il Yong Kim, Je Kyung Seong, Ho Lee, Sungsoon Fang, Sung Hee Baek
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/36d6b97040c64edea81c79e689652260
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spelling oai:doaj.org-article:36d6b97040c64edea81c79e6896522602021-12-02T13:24:15ZRORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network10.1038/s41467-017-00215-12041-1723https://doaj.org/article/36d6b97040c64edea81c79e6896522602017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00215-1https://doaj.org/toc/2041-1723Hepatic steatosis development may result from dysregulation of lipid metabolism, which is finely tuned by several transcription factors including the PPAR family. Here Kim et al. show that the nuclear receptor RORα inhibits PPARγ-mediated transcriptional activity by interacting with HDAC3 and competing for the promoters of lipogenic genes.Kyeongkyu KimKyungjin BooYoung Suk YuSe Kyu OhHyunkyung KimYoon JeonJinhyuk BhinDaehee HwangKeun Il KimJun-Su LeeSeung-Soon ImSeul Gi YoonIl Yong KimJe Kyung SeongHo LeeSungsoon FangSung Hee BaekNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kyeongkyu Kim
Kyungjin Boo
Young Suk Yu
Se Kyu Oh
Hyunkyung Kim
Yoon Jeon
Jinhyuk Bhin
Daehee Hwang
Keun Il Kim
Jun-Su Lee
Seung-Soon Im
Seul Gi Yoon
Il Yong Kim
Je Kyung Seong
Ho Lee
Sungsoon Fang
Sung Hee Baek
RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network
description Hepatic steatosis development may result from dysregulation of lipid metabolism, which is finely tuned by several transcription factors including the PPAR family. Here Kim et al. show that the nuclear receptor RORα inhibits PPARγ-mediated transcriptional activity by interacting with HDAC3 and competing for the promoters of lipogenic genes.
format article
author Kyeongkyu Kim
Kyungjin Boo
Young Suk Yu
Se Kyu Oh
Hyunkyung Kim
Yoon Jeon
Jinhyuk Bhin
Daehee Hwang
Keun Il Kim
Jun-Su Lee
Seung-Soon Im
Seul Gi Yoon
Il Yong Kim
Je Kyung Seong
Ho Lee
Sungsoon Fang
Sung Hee Baek
author_facet Kyeongkyu Kim
Kyungjin Boo
Young Suk Yu
Se Kyu Oh
Hyunkyung Kim
Yoon Jeon
Jinhyuk Bhin
Daehee Hwang
Keun Il Kim
Jun-Su Lee
Seung-Soon Im
Seul Gi Yoon
Il Yong Kim
Je Kyung Seong
Ho Lee
Sungsoon Fang
Sung Hee Baek
author_sort Kyeongkyu Kim
title RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network
title_short RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network
title_full RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network
title_fullStr RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network
title_full_unstemmed RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network
title_sort rorα controls hepatic lipid homeostasis via negative regulation of pparγ transcriptional network
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/36d6b97040c64edea81c79e689652260
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