Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
Here, the authors characterize tissue-level SARS-CoV-2 infection and pathogenesis in transgenic mice expressing human angiotensin converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18-hACE2) and show that infection induces lethality, making the K18-hACE2 model suitable for vaccine an...
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Nature Portfolio
2020
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oai:doaj.org-article:36d6d32972464a4aafa1c9bc198444932021-12-02T15:39:15ZLethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice10.1038/s41467-020-19891-72041-1723https://doaj.org/article/36d6d32972464a4aafa1c9bc198444932020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19891-7https://doaj.org/toc/2041-1723Here, the authors characterize tissue-level SARS-CoV-2 infection and pathogenesis in transgenic mice expressing human angiotensin converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18-hACE2) and show that infection induces lethality, making the K18-hACE2 model suitable for vaccine and therapeutic evaluation.Fatai S. OladunniJun-Gyu ParkPaula A. PinoOlga GonzalezAnwari AkhterAnna Allué-GuardiaAngélica Olmo-FontánezShalini GautamAndreu Garcia-VilanovaChengjin YeKevin ChiemColwyn HeadleyVarun DwivediLaura M. ParodiKendra J. AlfsonHilary M. StaplesAlyssa SchamiJuan I. GarciaAlison WhighamRoy Neal PlattMichal GaziJesse MartinezColin ChubaStephanie EarleyOscar H. RodriguezStephanie Davis MdakiKatrina N. KavelishRenee EscalonaCory R. A. HallamCorbett ChristieJean L. PattersonTim J. C. AndersonRicardo CarrionEdward J. DickShannan Hall-UrsoneLarry S. SchlesingerXavier AlvarezDeepak KaushalLuis D. GiavedoniJoanne TurnerLuis Martinez-SobridoJordi B. TorrellesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
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DOAJ |
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EN |
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Science Q |
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Science Q Fatai S. Oladunni Jun-Gyu Park Paula A. Pino Olga Gonzalez Anwari Akhter Anna Allué-Guardia Angélica Olmo-Fontánez Shalini Gautam Andreu Garcia-Vilanova Chengjin Ye Kevin Chiem Colwyn Headley Varun Dwivedi Laura M. Parodi Kendra J. Alfson Hilary M. Staples Alyssa Schami Juan I. Garcia Alison Whigham Roy Neal Platt Michal Gazi Jesse Martinez Colin Chuba Stephanie Earley Oscar H. Rodriguez Stephanie Davis Mdaki Katrina N. Kavelish Renee Escalona Cory R. A. Hallam Corbett Christie Jean L. Patterson Tim J. C. Anderson Ricardo Carrion Edward J. Dick Shannan Hall-Ursone Larry S. Schlesinger Xavier Alvarez Deepak Kaushal Luis D. Giavedoni Joanne Turner Luis Martinez-Sobrido Jordi B. Torrelles Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| description |
Here, the authors characterize tissue-level SARS-CoV-2 infection and pathogenesis in transgenic mice expressing human angiotensin converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18-hACE2) and show that infection induces lethality, making the K18-hACE2 model suitable for vaccine and therapeutic evaluation. |
| format |
article |
| author |
Fatai S. Oladunni Jun-Gyu Park Paula A. Pino Olga Gonzalez Anwari Akhter Anna Allué-Guardia Angélica Olmo-Fontánez Shalini Gautam Andreu Garcia-Vilanova Chengjin Ye Kevin Chiem Colwyn Headley Varun Dwivedi Laura M. Parodi Kendra J. Alfson Hilary M. Staples Alyssa Schami Juan I. Garcia Alison Whigham Roy Neal Platt Michal Gazi Jesse Martinez Colin Chuba Stephanie Earley Oscar H. Rodriguez Stephanie Davis Mdaki Katrina N. Kavelish Renee Escalona Cory R. A. Hallam Corbett Christie Jean L. Patterson Tim J. C. Anderson Ricardo Carrion Edward J. Dick Shannan Hall-Ursone Larry S. Schlesinger Xavier Alvarez Deepak Kaushal Luis D. Giavedoni Joanne Turner Luis Martinez-Sobrido Jordi B. Torrelles |
| author_facet |
Fatai S. Oladunni Jun-Gyu Park Paula A. Pino Olga Gonzalez Anwari Akhter Anna Allué-Guardia Angélica Olmo-Fontánez Shalini Gautam Andreu Garcia-Vilanova Chengjin Ye Kevin Chiem Colwyn Headley Varun Dwivedi Laura M. Parodi Kendra J. Alfson Hilary M. Staples Alyssa Schami Juan I. Garcia Alison Whigham Roy Neal Platt Michal Gazi Jesse Martinez Colin Chuba Stephanie Earley Oscar H. Rodriguez Stephanie Davis Mdaki Katrina N. Kavelish Renee Escalona Cory R. A. Hallam Corbett Christie Jean L. Patterson Tim J. C. Anderson Ricardo Carrion Edward J. Dick Shannan Hall-Ursone Larry S. Schlesinger Xavier Alvarez Deepak Kaushal Luis D. Giavedoni Joanne Turner Luis Martinez-Sobrido Jordi B. Torrelles |
| author_sort |
Fatai S. Oladunni |
| title |
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| title_short |
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| title_full |
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| title_fullStr |
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| title_full_unstemmed |
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice |
| title_sort |
lethality of sars-cov-2 infection in k18 human angiotensin-converting enzyme 2 transgenic mice |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/36d6d32972464a4aafa1c9bc19844493 |
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