Bioactive Hydrogel Marbles

Abstract Liquid marbles represented a significant advance in the manipulation of fluids as they used particle films to confine liquid drops, creating a robust and durable soft solid. We exploit this technology to engineering a bioactive hydrogel marble (BHM). Specifically, pristine bioactive glass n...

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Autores principales:	Álvaro J. Leite, Nuno M. Oliveira, Wenlong Song, João F. Mano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Liquid Marbles Bioactive Glass Nanoparticles (BGNPs) Bone-like Apatite Layer Cell Encapsulation Gelatin Methacrylate Medicine R Science Q
Acceso en línea:	https://doaj.org/article/36d79bf6c44f4037876c262bf211b24c
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id	oai:doaj.org-article:36d79bf6c44f4037876c262bf211b24c
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spelling	oai:doaj.org-article:36d79bf6c44f4037876c262bf211b24c2021-12-02T15:08:14ZBioactive Hydrogel Marbles10.1038/s41598-018-33192-62045-2322https://doaj.org/article/36d79bf6c44f4037876c262bf211b24c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33192-6https://doaj.org/toc/2045-2322Abstract Liquid marbles represented a significant advance in the manipulation of fluids as they used particle films to confine liquid drops, creating a robust and durable soft solid. We exploit this technology to engineering a bioactive hydrogel marble (BHM). Specifically, pristine bioactive glass nanoparticles were chemically tuned to produce biocompatible hydrophobic bioactive glass nanoparticles (H-BGNPs) that shielded a gelatin-based bead. The designed BHM shell promoted the growth of a bone-like apatite layer upon immersion in a physiological environment. The fabrication process allowed the efficient incorporation of drugs and cells into the engineered structure. The BHM provided a simultaneously controlled release of distinct encapsulated therapeutic model molecules. Moreover, the BHM sustained cell encapsulation in a 3D environment as demonstrated by an excellent in vitro stability and cytocompatibility. The engineered structures also showed potential to regulate a pre-osteoblastic cell line into osteogenic commitment. Overall, these hierarchical nanostructured and functional marbles revealed a high potential for future applications in bone tissue engineering.Álvaro J. LeiteNuno M. OliveiraWenlong SongJoão F. ManoNature PortfolioarticleLiquid MarblesBioactive Glass Nanoparticles (BGNPs)Bone-like Apatite LayerCell EncapsulationGelatin MethacrylateMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Liquid Marbles Bioactive Glass Nanoparticles (BGNPs) Bone-like Apatite Layer Cell Encapsulation Gelatin Methacrylate Medicine R Science Q
spellingShingle	Liquid Marbles Bioactive Glass Nanoparticles (BGNPs) Bone-like Apatite Layer Cell Encapsulation Gelatin Methacrylate Medicine R Science Q Álvaro J. Leite Nuno M. Oliveira Wenlong Song João F. Mano Bioactive Hydrogel Marbles
description	Abstract Liquid marbles represented a significant advance in the manipulation of fluids as they used particle films to confine liquid drops, creating a robust and durable soft solid. We exploit this technology to engineering a bioactive hydrogel marble (BHM). Specifically, pristine bioactive glass nanoparticles were chemically tuned to produce biocompatible hydrophobic bioactive glass nanoparticles (H-BGNPs) that shielded a gelatin-based bead. The designed BHM shell promoted the growth of a bone-like apatite layer upon immersion in a physiological environment. The fabrication process allowed the efficient incorporation of drugs and cells into the engineered structure. The BHM provided a simultaneously controlled release of distinct encapsulated therapeutic model molecules. Moreover, the BHM sustained cell encapsulation in a 3D environment as demonstrated by an excellent in vitro stability and cytocompatibility. The engineered structures also showed potential to regulate a pre-osteoblastic cell line into osteogenic commitment. Overall, these hierarchical nanostructured and functional marbles revealed a high potential for future applications in bone tissue engineering.
format	article
author	Álvaro J. Leite Nuno M. Oliveira Wenlong Song João F. Mano
author_facet	Álvaro J. Leite Nuno M. Oliveira Wenlong Song João F. Mano
author_sort	Álvaro J. Leite
title	Bioactive Hydrogel Marbles
title_short	Bioactive Hydrogel Marbles
title_full	Bioactive Hydrogel Marbles
title_fullStr	Bioactive Hydrogel Marbles
title_full_unstemmed	Bioactive Hydrogel Marbles
title_sort	bioactive hydrogel marbles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/36d79bf6c44f4037876c262bf211b24c
work_keys_str_mv	AT alvarojleite bioactivehydrogelmarbles AT nunomoliveira bioactivehydrogelmarbles AT wenlongsong bioactivehydrogelmarbles AT joaofmano bioactivehydrogelmarbles
_version_	1718388178736381952

Bioactive Hydrogel Marbles

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