AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania

Kaposi’s sarcoma (KS) was peculiarly described in the first notified cases of the acquired immunodeficiency syndrome as an opportunistic condition. However, the medical progress and the development of active antiretroviral therapy allowed the control of the HIV/AIDS epidemic, although the features o...

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Autores principales:	Manuela Arbune, Monica-Daniela Padurariu-Covit, Laura-Florentina Rebegea, Gabriela Lupasteanu, Anca-Adriana Arbune, Victorita Stefanescu, Alin-Laurentiu Tatu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	AIDS Kaposi’s sarcoma highly active antiretroviral therapy immune reconstruction inflammatory syndrome co-infections Medicine R
Acceso en línea:	https://doaj.org/article/36d988179b364172b0c015d5bf94322e
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spelling	oai:doaj.org-article:36d988179b364172b0c015d5bf94322e2021-11-25T18:01:56ZAIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania10.3390/jcm102253462077-0383https://doaj.org/article/36d988179b364172b0c015d5bf94322e2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5346https://doaj.org/toc/2077-0383Kaposi’s sarcoma (KS) was peculiarly described in the first notified cases of the acquired immunodeficiency syndrome as an opportunistic condition. However, the medical progress and the development of active antiretroviral therapy allowed the control of the HIV/AIDS epidemic, although the features of KS have changed throughout the past decades. The purpose of our study is to assess the epidemiological and clinical features of AIDS related KS in Romanian patients. A retrospective follow-up study was achieved in a single infectious diseases’ clinic from Galati—Romania, between 2001 and 2021. Referring to 290 new HIV diagnosed cases from our clinic retained in care, the prevalence of KS was 3.4%. The main characteristics of patients with KS are a median age of 33, a predominance of males, prevalent severe systemic forms of diseases, frequent association of past or concomitant tuberculosis, and context of immune reconstruction syndrome. The mortality rate was 70%. KS has occurred in patients with delayed HIV diagnoses and inadequate adherence to therapy. Early recognition of both infections, the close monitoring of latent or symptomatic tuberculosis, improving the antiretroviral adherence and raising the access to oncologic procedures in Romanian HIV patients could improve their prognosis related to KS.Manuela ArbuneMonica-Daniela Padurariu-CovitLaura-Florentina RebegeaGabriela LupasteanuAnca-Adriana ArbuneVictorita StefanescuAlin-Laurentiu TatuMDPI AGarticleAIDSKaposi’s sarcomahighly active antiretroviral therapyimmune reconstruction inflammatory syndromeco-infectionsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5346, p 5346 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AIDS Kaposi’s sarcoma highly active antiretroviral therapy immune reconstruction inflammatory syndrome co-infections Medicine R
spellingShingle	AIDS Kaposi’s sarcoma highly active antiretroviral therapy immune reconstruction inflammatory syndrome co-infections Medicine R Manuela Arbune Monica-Daniela Padurariu-Covit Laura-Florentina Rebegea Gabriela Lupasteanu Anca-Adriana Arbune Victorita Stefanescu Alin-Laurentiu Tatu AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania
description	Kaposi’s sarcoma (KS) was peculiarly described in the first notified cases of the acquired immunodeficiency syndrome as an opportunistic condition. However, the medical progress and the development of active antiretroviral therapy allowed the control of the HIV/AIDS epidemic, although the features of KS have changed throughout the past decades. The purpose of our study is to assess the epidemiological and clinical features of AIDS related KS in Romanian patients. A retrospective follow-up study was achieved in a single infectious diseases’ clinic from Galati—Romania, between 2001 and 2021. Referring to 290 new HIV diagnosed cases from our clinic retained in care, the prevalence of KS was 3.4%. The main characteristics of patients with KS are a median age of 33, a predominance of males, prevalent severe systemic forms of diseases, frequent association of past or concomitant tuberculosis, and context of immune reconstruction syndrome. The mortality rate was 70%. KS has occurred in patients with delayed HIV diagnoses and inadequate adherence to therapy. Early recognition of both infections, the close monitoring of latent or symptomatic tuberculosis, improving the antiretroviral adherence and raising the access to oncologic procedures in Romanian HIV patients could improve their prognosis related to KS.
format	article
author	Manuela Arbune Monica-Daniela Padurariu-Covit Laura-Florentina Rebegea Gabriela Lupasteanu Anca-Adriana Arbune Victorita Stefanescu Alin-Laurentiu Tatu
author_facet	Manuela Arbune Monica-Daniela Padurariu-Covit Laura-Florentina Rebegea Gabriela Lupasteanu Anca-Adriana Arbune Victorita Stefanescu Alin-Laurentiu Tatu
author_sort	Manuela Arbune
title	AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania
title_short	AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania
title_full	AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania
title_fullStr	AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania
title_full_unstemmed	AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania
title_sort	aids related kaposi’s sarcoma: a 20-year experience in a clinic from the south-east of romania
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/36d988179b364172b0c015d5bf94322e
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AIDS Related Kaposi’s Sarcoma: A 20-Year Experience in a Clinic from the South-East of Romania

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