Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria

Abstract Vancomycin is known to bind to Zn(II) and can induce a zinc starvation response in bacteria. Here we identify a novel polymerization of vancomycin dimers by structural analysis of vancomycin-Zn(II) crystals and fibre X-ray diffraction. Bioassays indicate that this structure is associated wi...

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Autores principales: Ashraf Zarkan, Heather-Rose Macklyne, Dimitri Y. Chirgadze, Andrew D. Bond, Andrew R. Hesketh, Hee-Jeon Hong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/36da0b6203544be3912a0cf3797ab0ad
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