ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking

The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ganglion neurons.

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Autores principales:	Man-Xiu Xie, Xian-Ying Cao, Wei-An Zeng, Ren-Chun Lai, Lan Guo, Jun-Chao Wang, Yi-Bin Xiao, Xi Zhang, Di Chen, Xian-Guo Liu, Xiao-Long Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36dff54f48e64262870135e11a4c0043
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spelling	oai:doaj.org-article:36dff54f48e64262870135e11a4c00432021-12-02T15:53:26ZATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking10.1038/s41467-021-21731-12041-1723https://doaj.org/article/36dff54f48e64262870135e11a4c00432021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21731-1https://doaj.org/toc/2041-1723The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ganglion neurons.Man-Xiu XieXian-Ying CaoWei-An ZengRen-Chun LaiLan GuoJun-Chao WangYi-Bin XiaoXi ZhangDi ChenXian-Guo LiuXiao-Long ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Man-Xiu Xie Xian-Ying Cao Wei-An Zeng Ren-Chun Lai Lan Guo Jun-Chao Wang Yi-Bin Xiao Xi Zhang Di Chen Xian-Guo Liu Xiao-Long Zhang ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
description	The molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ATF4 role in mediating protein trafficking in dorsal root ganglion neurons.
format	article
author	Man-Xiu Xie Xian-Ying Cao Wei-An Zeng Ren-Chun Lai Lan Guo Jun-Chao Wang Yi-Bin Xiao Xi Zhang Di Chen Xian-Guo Liu Xiao-Long Zhang
author_facet	Man-Xiu Xie Xian-Ying Cao Wei-An Zeng Ren-Chun Lai Lan Guo Jun-Chao Wang Yi-Bin Xiao Xi Zhang Di Chen Xian-Guo Liu Xiao-Long Zhang
author_sort	Man-Xiu Xie
title	ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
title_short	ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
title_full	ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
title_fullStr	ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
title_full_unstemmed	ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
title_sort	atf4 selectively regulates heat nociception and contributes to kinesin-mediated trpm3 trafficking
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/36dff54f48e64262870135e11a4c0043
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ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking

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