A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells

Cyclic dinucleotides are conserved second messengers but current detection methods are limited. Here the authors engineer a Förster resonance energy transfer (FRET) based biosensor, BioSTING, which gives real-time in vitro detection of these nucleotides.

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Detalles Bibliográficos
Autores principales:	Alex J. Pollock, Shivam A. Zaver, Joshua J. Woodward
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36e75b0016f64dfabbbed5db9206e8d5
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spelling	oai:doaj.org-article:36e75b0016f64dfabbbed5db9206e8d52021-12-02T15:33:05ZA STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells10.1038/s41467-020-17228-y2041-1723https://doaj.org/article/36e75b0016f64dfabbbed5db9206e8d52020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17228-yhttps://doaj.org/toc/2041-1723Cyclic dinucleotides are conserved second messengers but current detection methods are limited. Here the authors engineer a Förster resonance energy transfer (FRET) based biosensor, BioSTING, which gives real-time in vitro detection of these nucleotides.Alex J. PollockShivam A. ZaverJoshua J. WoodwardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alex J. Pollock Shivam A. Zaver Joshua J. Woodward A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
description	Cyclic dinucleotides are conserved second messengers but current detection methods are limited. Here the authors engineer a Förster resonance energy transfer (FRET) based biosensor, BioSTING, which gives real-time in vitro detection of these nucleotides.
format	article
author	Alex J. Pollock Shivam A. Zaver Joshua J. Woodward
author_facet	Alex J. Pollock Shivam A. Zaver Joshua J. Woodward
author_sort	Alex J. Pollock
title	A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
title_short	A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
title_full	A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
title_fullStr	A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
title_full_unstemmed	A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
title_sort	sting-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/36e75b0016f64dfabbbed5db9206e8d5
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A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells

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