A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
Cyclic dinucleotides are conserved second messengers but current detection methods are limited. Here the authors engineer a Förster resonance energy transfer (FRET) based biosensor, BioSTING, which gives real-time in vitro detection of these nucleotides.
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Autores principales: | Alex J. Pollock, Shivam A. Zaver, Joshua J. Woodward |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/36e75b0016f64dfabbbed5db9206e8d5 |
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