Dietary natural products as a potential inhibitor towards advanced glycation end products and hyperglycemic complications: A phytotherapy approaches

Natural products exist in various natural foods such as plants, herbs, fruits, and vegetables. Furthermore, marine life offers potential natural products with significant biological activity. The biochemical reaction is known as advanced glycation end products (AGEs) occurs in the human body. On the...

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Autores principales:	Vijaykrishnaraj M., Kuiwu Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Natural products Flavonoids Glycation Hyperglycemia AGEs & inhibitors Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/36e9436794a643cd93be7f15672bb5d6
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spelling	oai:doaj.org-article:36e9436794a643cd93be7f15672bb5d62021-11-14T04:29:57ZDietary natural products as a potential inhibitor towards advanced glycation end products and hyperglycemic complications: A phytotherapy approaches0753-332210.1016/j.biopha.2021.112336https://doaj.org/article/36e9436794a643cd93be7f15672bb5d62021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011203https://doaj.org/toc/0753-3322Natural products exist in various natural foods such as plants, herbs, fruits, and vegetables. Furthermore, marine life offers potential natural products with significant biological activity. The biochemical reaction is known as advanced glycation end products (AGEs) occurs in the human body. On the other hand, foods are capable of a wide range of processing conditions resulting in the generation of exogenous AGEs adducts. Protein glycation and the formation of advanced glycation end products both contribute to the pathogenesis of hyperglycemic complications. AGEs also play a pivotal role in microvascular and macrovascular complications progression by receptors for advanced glycation end products (RAGE). RAGE activate by AGEs leads to up-regulation of transcriptional factor NF-kB and inflammatory genes. Around the globe, researchers are working in various approaches for therapeutical implications on controlling AGEs mediated disease complications. In this regard, one of the potential promising agents observed with a wide range of AGEs inhibition by food-derived natural products. Current biotechnological tools have been turned to natural products or phytochemicals to manufacture the molecules without compromising their functionality. Metabolic engineering and bioinformatics perspectives have recently enabled the generation of a few potent metabolites with anti-diabetic activity. As the primary focus, this review article will also discuss multidisciplinary approaches that emphasize current advances in anti-diabetic therapeutic action and future perspectives of natural products.Vijaykrishnaraj M.Kuiwu WangElsevierarticleNatural productsFlavonoidsGlycationHyperglycemiaAGEs & inhibitorsTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112336- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Natural products Flavonoids Glycation Hyperglycemia AGEs & inhibitors Therapeutics. Pharmacology RM1-950
spellingShingle	Natural products Flavonoids Glycation Hyperglycemia AGEs & inhibitors Therapeutics. Pharmacology RM1-950 Vijaykrishnaraj M. Kuiwu Wang Dietary natural products as a potential inhibitor towards advanced glycation end products and hyperglycemic complications: A phytotherapy approaches
description	Natural products exist in various natural foods such as plants, herbs, fruits, and vegetables. Furthermore, marine life offers potential natural products with significant biological activity. The biochemical reaction is known as advanced glycation end products (AGEs) occurs in the human body. On the other hand, foods are capable of a wide range of processing conditions resulting in the generation of exogenous AGEs adducts. Protein glycation and the formation of advanced glycation end products both contribute to the pathogenesis of hyperglycemic complications. AGEs also play a pivotal role in microvascular and macrovascular complications progression by receptors for advanced glycation end products (RAGE). RAGE activate by AGEs leads to up-regulation of transcriptional factor NF-kB and inflammatory genes. Around the globe, researchers are working in various approaches for therapeutical implications on controlling AGEs mediated disease complications. In this regard, one of the potential promising agents observed with a wide range of AGEs inhibition by food-derived natural products. Current biotechnological tools have been turned to natural products or phytochemicals to manufacture the molecules without compromising their functionality. Metabolic engineering and bioinformatics perspectives have recently enabled the generation of a few potent metabolites with anti-diabetic activity. As the primary focus, this review article will also discuss multidisciplinary approaches that emphasize current advances in anti-diabetic therapeutic action and future perspectives of natural products.
format	article
author	Vijaykrishnaraj M. Kuiwu Wang
author_facet	Vijaykrishnaraj M. Kuiwu Wang
author_sort	Vijaykrishnaraj M.
title	Dietary natural products as a potential inhibitor towards advanced glycation end products and hyperglycemic complications: A phytotherapy approaches
title_short	Dietary natural products as a potential inhibitor towards advanced glycation end products and hyperglycemic complications: A phytotherapy approaches
title_full	Dietary natural products as a potential inhibitor towards advanced glycation end products and hyperglycemic complications: A phytotherapy approaches
title_fullStr	Dietary natural products as a potential inhibitor towards advanced glycation end products and hyperglycemic complications: A phytotherapy approaches
title_full_unstemmed	Dietary natural products as a potential inhibitor towards advanced glycation end products and hyperglycemic complications: A phytotherapy approaches
title_sort	dietary natural products as a potential inhibitor towards advanced glycation end products and hyperglycemic complications: a phytotherapy approaches
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/36e9436794a643cd93be7f15672bb5d6
work_keys_str_mv	AT vijaykrishnarajm dietarynaturalproductsasapotentialinhibitortowardsadvancedglycationendproductsandhyperglycemiccomplicationsaphytotherapyapproaches AT kuiwuwang dietarynaturalproductsasapotentialinhibitortowardsadvancedglycationendproductsandhyperglycemiccomplicationsaphytotherapyapproaches
_version_	1718430007614767104

Dietary natural products as a potential inhibitor towards advanced glycation end products and hyperglycemic complications: A phytotherapy approaches

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