1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation

Abstract Acupuncture is a traditional Chinese medicine therapy that has been found useful for treating various diseases. The treatments involve the insertion of fine needles at acupoints along specific meridians (meridian specificity). This study aims to investigate the metabolic basis of meridian s...

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Autores principales:	Caigui Lin, Zhiliang Wei, Kian-Kai Cheng, Jingjing Xu, Guiping Shen, Chang She, Huan Zhong, Xiaorong Chang, Jiyang Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/36ec5ab236ed4afdb4749f4df1c87cd4
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spelling	oai:doaj.org-article:36ec5ab236ed4afdb4749f4df1c87cd42021-12-02T16:06:34Z1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation10.1038/s41598-017-07306-52045-2322https://doaj.org/article/36ec5ab236ed4afdb4749f4df1c87cd42017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07306-5https://doaj.org/toc/2045-2322Abstract Acupuncture is a traditional Chinese medicine therapy that has been found useful for treating various diseases. The treatments involve the insertion of fine needles at acupoints along specific meridians (meridian specificity). This study aims to investigate the metabolic basis of meridian specificity using proton nuclear magnetic resonance (1H NMR)-based metabolomics. Electro-acupuncture (EA) stimulations were performed at acupoints of either Stomach Meridian of Foot-Yangming (SMFY) or Gallbladder Meridian of Foot-Shaoyang (GMFS) in healthy male Sprague Dawley (SD) rats. 1H-NMR spectra datasets of serum, urine, cortex, and stomach tissue extracts from the rats were analysed by multivariate statistical analysis to investigate metabolic perturbations due to EA treatments at different meridians. EA treatment on either the SMFY or GMFS acupoints induced significant variations in 31 metabolites, e.g., amino acids, organic acids, choline esters and glucose. Moreover, a few meridian-specific metabolic changes were found for EA stimulations on the SMFY or GMFS acupoints. Our study demonstrated significant metabolic differences in response to EA stimulations on acupoints of SMFY and GMFS meridians. These results validate the hypothesis that meridian specificity in acupuncture is detectable in the metabolome and demonstrate the feasibility and effectiveness of a metabolomics approach in understanding the mechanism of acupuncture.Caigui LinZhiliang WeiKian-Kai ChengJingjing XuGuiping ShenChang SheHuan ZhongXiaorong ChangJiyang DongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caigui Lin Zhiliang Wei Kian-Kai Cheng Jingjing Xu Guiping Shen Chang She Huan Zhong Xiaorong Chang Jiyang Dong 1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation
description	Abstract Acupuncture is a traditional Chinese medicine therapy that has been found useful for treating various diseases. The treatments involve the insertion of fine needles at acupoints along specific meridians (meridian specificity). This study aims to investigate the metabolic basis of meridian specificity using proton nuclear magnetic resonance (1H NMR)-based metabolomics. Electro-acupuncture (EA) stimulations were performed at acupoints of either Stomach Meridian of Foot-Yangming (SMFY) or Gallbladder Meridian of Foot-Shaoyang (GMFS) in healthy male Sprague Dawley (SD) rats. 1H-NMR spectra datasets of serum, urine, cortex, and stomach tissue extracts from the rats were analysed by multivariate statistical analysis to investigate metabolic perturbations due to EA treatments at different meridians. EA treatment on either the SMFY or GMFS acupoints induced significant variations in 31 metabolites, e.g., amino acids, organic acids, choline esters and glucose. Moreover, a few meridian-specific metabolic changes were found for EA stimulations on the SMFY or GMFS acupoints. Our study demonstrated significant metabolic differences in response to EA stimulations on acupoints of SMFY and GMFS meridians. These results validate the hypothesis that meridian specificity in acupuncture is detectable in the metabolome and demonstrate the feasibility and effectiveness of a metabolomics approach in understanding the mechanism of acupuncture.
format	article
author	Caigui Lin Zhiliang Wei Kian-Kai Cheng Jingjing Xu Guiping Shen Chang She Huan Zhong Xiaorong Chang Jiyang Dong
author_facet	Caigui Lin Zhiliang Wei Kian-Kai Cheng Jingjing Xu Guiping Shen Chang She Huan Zhong Xiaorong Chang Jiyang Dong
author_sort	Caigui Lin
title	1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation
title_short	1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation
title_full	1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation
title_fullStr	1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation
title_full_unstemmed	1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation
title_sort	1h nmr-based investigation of metabolic response to electro-acupuncture stimulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/36ec5ab236ed4afdb4749f4df1c87cd4
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1H NMR-based Investigation of Metabolic Response to Electro-Acupuncture Stimulation

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