C-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh

Abstract The introduction of biological or absorbable synthetic meshes has provided an alternative to conventional repair for incisional hernia. The ability to predict the development of complications after hernia surgery is important, as it guides surgical planning and patient management. This retr...

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Autores principales:	Julien Janet, Sophiane Derbal, Sylvaine Durand Fontanier, Stephane Bouvier, Niki Christou, Anne Fabre, Fabien Fredon, Thibaud Rivaille, Denis Valleix, Muriel Mathonnet, Abdelkader Taibi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/36edc7cc21ca418794ab935fdb589348
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spelling	oai:doaj.org-article:36edc7cc21ca418794ab935fdb5893482021-12-02T14:28:20ZC-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh10.1038/s41598-021-83663-62045-2322https://doaj.org/article/36edc7cc21ca418794ab935fdb5893482021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83663-6https://doaj.org/toc/2045-2322Abstract The introduction of biological or absorbable synthetic meshes has provided an alternative to conventional repair for incisional hernia. The ability to predict the development of complications after hernia surgery is important, as it guides surgical planning and patient management. This retrospective study assessed whether the postoperative C-reactive protein (CRP) level can predict complications after incisional hernia repair using biological mesh reinforcement. Patients who underwent incisional hernia repair surgery using biological meshes between February 2009 and February 2015 were screened for study inclusion. Patients included in the study were divided into two groups: those with and without postoperative complications. The two groups were analysed based on sex, surgical operation, length of intensive care unit stay (ICU), complications and mortality. Laboratory values, including white blood cell (WBC) count and CRP levels, were determined preoperatively and up to postoperative day (POD) 10. Postoperative complications requiring further management occurred in 32 of the 60 patients (53.3%). Among 47 patients, the mean CRP and WBC levels were 6.6 mg/L and 9.073 G/L in the group without complications vs. 141.0 mg/L, 16.704 G/L in the group with complications (p < 0.001). Patients with complications also had a longer ICU stay (10.1 vs. 0.6 days, p < 0.0001). A cut-off was 101 mg/L and offered 80.00% sensitivity (IC 61.43% to 92.29) and 95.24% specificity (76.18% to 99.88%) for postoperative complication. The rate of postoperative complications before POD10 was 95% in the group with CRP > 100 mg/L vs. 46% in the group with CRP < 100 mg/L (p = 0.000372). A high postoperative CRP level (> 100 mg/L) up to POD10 may serve as a predictor of postoperative complications in patients undergoing incisional hernia using biological meshes.Julien JanetSophiane DerbalSylvaine Durand FontanierStephane BouvierNiki ChristouAnne FabreFabien FredonThibaud RivailleDenis ValleixMuriel MathonnetAbdelkader TaibiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julien Janet Sophiane Derbal Sylvaine Durand Fontanier Stephane Bouvier Niki Christou Anne Fabre Fabien Fredon Thibaud Rivaille Denis Valleix Muriel Mathonnet Abdelkader Taibi C-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh
description	Abstract The introduction of biological or absorbable synthetic meshes has provided an alternative to conventional repair for incisional hernia. The ability to predict the development of complications after hernia surgery is important, as it guides surgical planning and patient management. This retrospective study assessed whether the postoperative C-reactive protein (CRP) level can predict complications after incisional hernia repair using biological mesh reinforcement. Patients who underwent incisional hernia repair surgery using biological meshes between February 2009 and February 2015 were screened for study inclusion. Patients included in the study were divided into two groups: those with and without postoperative complications. The two groups were analysed based on sex, surgical operation, length of intensive care unit stay (ICU), complications and mortality. Laboratory values, including white blood cell (WBC) count and CRP levels, were determined preoperatively and up to postoperative day (POD) 10. Postoperative complications requiring further management occurred in 32 of the 60 patients (53.3%). Among 47 patients, the mean CRP and WBC levels were 6.6 mg/L and 9.073 G/L in the group without complications vs. 141.0 mg/L, 16.704 G/L in the group with complications (p < 0.001). Patients with complications also had a longer ICU stay (10.1 vs. 0.6 days, p < 0.0001). A cut-off was 101 mg/L and offered 80.00% sensitivity (IC 61.43% to 92.29) and 95.24% specificity (76.18% to 99.88%) for postoperative complication. The rate of postoperative complications before POD10 was 95% in the group with CRP > 100 mg/L vs. 46% in the group with CRP < 100 mg/L (p = 0.000372). A high postoperative CRP level (> 100 mg/L) up to POD10 may serve as a predictor of postoperative complications in patients undergoing incisional hernia using biological meshes.
format	article
author	Julien Janet Sophiane Derbal Sylvaine Durand Fontanier Stephane Bouvier Niki Christou Anne Fabre Fabien Fredon Thibaud Rivaille Denis Valleix Muriel Mathonnet Abdelkader Taibi
author_facet	Julien Janet Sophiane Derbal Sylvaine Durand Fontanier Stephane Bouvier Niki Christou Anne Fabre Fabien Fredon Thibaud Rivaille Denis Valleix Muriel Mathonnet Abdelkader Taibi
author_sort	Julien Janet
title	C-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh
title_short	C-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh
title_full	C-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh
title_fullStr	C-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh
title_full_unstemmed	C-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh
title_sort	c-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/36edc7cc21ca418794ab935fdb589348
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C-reactive protein is a predictive factor for complications after incisional hernia repair using a biological mesh

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