Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.

MicroRNAs are a large class of post-transcriptional regulators that bind to the 3' untranslated region of messenger RNAs. They play a critical role in many cellular processes and have been linked to the control of signal transduction pathways. Recent studies indicate that microRNAs can function...

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Autores principales:	Andreas Kowarsch, Carsten Marr, Daniel Schmidl, Andreas Ruepp, Fabian J Theis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/36f13147c5914208bb6a094cefd812ec
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spelling	oai:doaj.org-article:36f13147c5914208bb6a094cefd812ec2021-12-02T20:20:22ZTissue-specific target analysis of disease-associated microRNAs in human signaling pathways.1932-620310.1371/journal.pone.0011154https://doaj.org/article/36f13147c5914208bb6a094cefd812ec2010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20614023/?tool=EBIhttps://doaj.org/toc/1932-6203MicroRNAs are a large class of post-transcriptional regulators that bind to the 3' untranslated region of messenger RNAs. They play a critical role in many cellular processes and have been linked to the control of signal transduction pathways. Recent studies indicate that microRNAs can function as tumor suppressors or even as oncogenes when aberrantly expressed. For more general insights of disease-associated microRNAs, we analyzed their impact on human signaling pathways from two perspectives. On a global scale, we found a core set of signaling pathways with enriched tissue-specific microRNA targets across diseases. The function of these pathways reflects the affinity of microRNAs to regulate cellular processes associated with apoptosis, proliferation or development. Comparing cancer and non-cancer related microRNAs, we found no significant differences between both groups. To unveil the interaction and regulation of microRNAs on signaling pathways locally, we analyzed the cellular location and process type of disease-associated microRNA targets and proteins. While disease-associated proteins are highly enriched in extracellular components of the pathway, microRNA targets are preferentially located in the nucleus. Moreover, targets of disease-associated microRNAs preferentially exhibit an inhibitory effect within the pathways in contrast to disease proteins. Our analysis provides systematic insights into the interaction of disease-associated microRNAs and signaling pathways and uncovers differences in cellular locations and process types of microRNA targets and disease-associated proteins.Andreas KowarschCarsten MarrDaniel SchmidlAndreas RueppFabian J TheisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 6, p e11154 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andreas Kowarsch Carsten Marr Daniel Schmidl Andreas Ruepp Fabian J Theis Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.
description	MicroRNAs are a large class of post-transcriptional regulators that bind to the 3' untranslated region of messenger RNAs. They play a critical role in many cellular processes and have been linked to the control of signal transduction pathways. Recent studies indicate that microRNAs can function as tumor suppressors or even as oncogenes when aberrantly expressed. For more general insights of disease-associated microRNAs, we analyzed their impact on human signaling pathways from two perspectives. On a global scale, we found a core set of signaling pathways with enriched tissue-specific microRNA targets across diseases. The function of these pathways reflects the affinity of microRNAs to regulate cellular processes associated with apoptosis, proliferation or development. Comparing cancer and non-cancer related microRNAs, we found no significant differences between both groups. To unveil the interaction and regulation of microRNAs on signaling pathways locally, we analyzed the cellular location and process type of disease-associated microRNA targets and proteins. While disease-associated proteins are highly enriched in extracellular components of the pathway, microRNA targets are preferentially located in the nucleus. Moreover, targets of disease-associated microRNAs preferentially exhibit an inhibitory effect within the pathways in contrast to disease proteins. Our analysis provides systematic insights into the interaction of disease-associated microRNAs and signaling pathways and uncovers differences in cellular locations and process types of microRNA targets and disease-associated proteins.
format	article
author	Andreas Kowarsch Carsten Marr Daniel Schmidl Andreas Ruepp Fabian J Theis
author_facet	Andreas Kowarsch Carsten Marr Daniel Schmidl Andreas Ruepp Fabian J Theis
author_sort	Andreas Kowarsch
title	Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.
title_short	Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.
title_full	Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.
title_fullStr	Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.
title_full_unstemmed	Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.
title_sort	tissue-specific target analysis of disease-associated micrornas in human signaling pathways.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/36f13147c5914208bb6a094cefd812ec
work_keys_str_mv	AT andreaskowarsch tissuespecifictargetanalysisofdiseaseassociatedmicrornasinhumansignalingpathways AT carstenmarr tissuespecifictargetanalysisofdiseaseassociatedmicrornasinhumansignalingpathways AT danielschmidl tissuespecifictargetanalysisofdiseaseassociatedmicrornasinhumansignalingpathways AT andreasruepp tissuespecifictargetanalysisofdiseaseassociatedmicrornasinhumansignalingpathways AT fabianjtheis tissuespecifictargetanalysisofdiseaseassociatedmicrornasinhumansignalingpathways
_version_	1718374158705885184

Tissue-specific target analysis of disease-associated microRNAs in human signaling pathways.

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