SNAIL1: Linking Tumor Metastasis to Immune Evasion

The transcription factor Snail1, a key inducer of epithelial-mesenchymal transition (EMT), plays a critical role in tumor metastasis. Its stability is strictly controlled by multiple intracellular signal transduction pathways and the ubiquitin-proteasome system (UPS). Increasing evidence indicates t...

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Autores principales:	Xiaolong Tang, Xue Sui, Liang Weng, Yongshuo Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Snail1 EMT signaling pathway ubiquitination methylation acetylation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/36f197aebc35430ba94b7edfedebcee5
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spelling	oai:doaj.org-article:36f197aebc35430ba94b7edfedebcee52021-12-01T16:42:47ZSNAIL1: Linking Tumor Metastasis to Immune Evasion1664-322410.3389/fimmu.2021.724200https://doaj.org/article/36f197aebc35430ba94b7edfedebcee52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.724200/fullhttps://doaj.org/toc/1664-3224The transcription factor Snail1, a key inducer of epithelial-mesenchymal transition (EMT), plays a critical role in tumor metastasis. Its stability is strictly controlled by multiple intracellular signal transduction pathways and the ubiquitin-proteasome system (UPS). Increasing evidence indicates that methylation and acetylation of Snail1 also affects tumor metastasis. More importantly, Snail1 is involved in tumor immunosuppression by inducing chemokines and immunosuppressive cells into the tumor microenvironment (TME). In addition, some immune checkpoints potentiate Snail1 expression, such as programmed death ligand 1 (PD-L1) and T cell immunoglobulin 3 (TIM-3). This mini review highlights the pathways and molecules involved in maintenance of Snail1 level and the significance of Snail1 in tumor immune evasion. Due to the crucial role of EMT in tumor metastasis and tumor immunosuppression, comprehensive understanding of Snail1 function may contribute to the development of novel therapeutics for cancer.Xiaolong TangXue SuiLiang WengLiang WengLiang WengLiang WengLiang WengLiang WengYongshuo LiuYongshuo LiuFrontiers Media S.A.articleSnail1EMTsignaling pathwayubiquitinationmethylationacetylationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Snail1 EMT signaling pathway ubiquitination methylation acetylation Immunologic diseases. Allergy RC581-607
spellingShingle	Snail1 EMT signaling pathway ubiquitination methylation acetylation Immunologic diseases. Allergy RC581-607 Xiaolong Tang Xue Sui Liang Weng Liang Weng Liang Weng Liang Weng Liang Weng Liang Weng Yongshuo Liu Yongshuo Liu SNAIL1: Linking Tumor Metastasis to Immune Evasion
description	The transcription factor Snail1, a key inducer of epithelial-mesenchymal transition (EMT), plays a critical role in tumor metastasis. Its stability is strictly controlled by multiple intracellular signal transduction pathways and the ubiquitin-proteasome system (UPS). Increasing evidence indicates that methylation and acetylation of Snail1 also affects tumor metastasis. More importantly, Snail1 is involved in tumor immunosuppression by inducing chemokines and immunosuppressive cells into the tumor microenvironment (TME). In addition, some immune checkpoints potentiate Snail1 expression, such as programmed death ligand 1 (PD-L1) and T cell immunoglobulin 3 (TIM-3). This mini review highlights the pathways and molecules involved in maintenance of Snail1 level and the significance of Snail1 in tumor immune evasion. Due to the crucial role of EMT in tumor metastasis and tumor immunosuppression, comprehensive understanding of Snail1 function may contribute to the development of novel therapeutics for cancer.
format	article
author	Xiaolong Tang Xue Sui Liang Weng Liang Weng Liang Weng Liang Weng Liang Weng Liang Weng Yongshuo Liu Yongshuo Liu
author_facet	Xiaolong Tang Xue Sui Liang Weng Liang Weng Liang Weng Liang Weng Liang Weng Liang Weng Yongshuo Liu Yongshuo Liu
author_sort	Xiaolong Tang
title	SNAIL1: Linking Tumor Metastasis to Immune Evasion
title_short	SNAIL1: Linking Tumor Metastasis to Immune Evasion
title_full	SNAIL1: Linking Tumor Metastasis to Immune Evasion
title_fullStr	SNAIL1: Linking Tumor Metastasis to Immune Evasion
title_full_unstemmed	SNAIL1: Linking Tumor Metastasis to Immune Evasion
title_sort	snail1: linking tumor metastasis to immune evasion
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/36f197aebc35430ba94b7edfedebcee5
work_keys_str_mv	AT xiaolongtang snail1linkingtumormetastasistoimmuneevasion AT xuesui snail1linkingtumormetastasistoimmuneevasion AT liangweng snail1linkingtumormetastasistoimmuneevasion AT liangweng snail1linkingtumormetastasistoimmuneevasion AT liangweng snail1linkingtumormetastasistoimmuneevasion AT liangweng snail1linkingtumormetastasistoimmuneevasion AT liangweng snail1linkingtumormetastasistoimmuneevasion AT liangweng snail1linkingtumormetastasistoimmuneevasion AT yongshuoliu snail1linkingtumormetastasistoimmuneevasion AT yongshuoliu snail1linkingtumormetastasistoimmuneevasion
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SNAIL1: Linking Tumor Metastasis to Immune Evasion

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