The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies

Interest in the role of coagulation and fibrinolysis in the nervous system was active in several laboratories dating back before cloning of the functional thrombin receptor in 1991. As one of those, our attention was initially on thrombin and plasminogen activators in synapse formation and eliminati...

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Autores principales:	Barry W. Festoff, Chris Dockendorff
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neurodegeneration neurotrauma ALS inflammation thromboinflammation neuro-thromboinflammation Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/36f1bcfe095544b190983c03e84c4a0e
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id	oai:doaj.org-article:36f1bcfe095544b190983c03e84c4a0e
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spelling	oai:doaj.org-article:36f1bcfe095544b190983c03e84c4a0e2021-11-25T16:51:50ZThe Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies10.3390/biom111115582218-273Xhttps://doaj.org/article/36f1bcfe095544b190983c03e84c4a0e2021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1558https://doaj.org/toc/2218-273XInterest in the role of coagulation and fibrinolysis in the nervous system was active in several laboratories dating back before cloning of the functional thrombin receptor in 1991. As one of those, our attention was initially on thrombin and plasminogen activators in synapse formation and elimination in the neuromuscular system, with orientation towards diseases such as amyotrophic lateral sclerosis (ALS) and how clotting and fibrinolytic pathways fit into its pathogenesis. This perspective is on neuro-thromboinflammation, emphasizing this emerging concept from studies and reports over more than three decades. It underscores how it may lead to novel therapeutic approaches to treat the ravages of neurotrauma and neurodegenerative diseases, with a focus on PAR1, ALS, and parmodulins.Barry W. FestoffChris DockendorffMDPI AGarticleneurodegenerationneurotraumaALSinflammationthromboinflammationneuro-thromboinflammationMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1558, p 1558 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurodegeneration neurotrauma ALS inflammation thromboinflammation neuro-thromboinflammation Microbiology QR1-502
spellingShingle	neurodegeneration neurotrauma ALS inflammation thromboinflammation neuro-thromboinflammation Microbiology QR1-502 Barry W. Festoff Chris Dockendorff The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies
description	Interest in the role of coagulation and fibrinolysis in the nervous system was active in several laboratories dating back before cloning of the functional thrombin receptor in 1991. As one of those, our attention was initially on thrombin and plasminogen activators in synapse formation and elimination in the neuromuscular system, with orientation towards diseases such as amyotrophic lateral sclerosis (ALS) and how clotting and fibrinolytic pathways fit into its pathogenesis. This perspective is on neuro-thromboinflammation, emphasizing this emerging concept from studies and reports over more than three decades. It underscores how it may lead to novel therapeutic approaches to treat the ravages of neurotrauma and neurodegenerative diseases, with a focus on PAR1, ALS, and parmodulins.
format	article
author	Barry W. Festoff Chris Dockendorff
author_facet	Barry W. Festoff Chris Dockendorff
author_sort	Barry W. Festoff
title	The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies
title_short	The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies
title_full	The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies
title_fullStr	The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies
title_full_unstemmed	The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies
title_sort	evolving concept of neuro-thromboinflammation for neurodegenerative disorders and neurotrauma: a rationale for par1-targeting therapies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/36f1bcfe095544b190983c03e84c4a0e
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The Evolving Concept of Neuro-Thromboinflammation for Neurodegenerative Disorders and Neurotrauma: A Rationale for PAR1-Targeting Therapies

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