Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase

Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase

Diamond Blackfan Anemia (DBA) is a congenital bone marrow failure syndrome that is associated with anemia. Here, the authors examine the role of Nemo-like kinase (NLK) in erythroid cells in the pathogenesis of DBA and as a potential target for therapy.

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Main Authors: M. C. Wilkes, K. Siva, J. Chen, G. Varetti, M. Y. Youn, H. Chae, F. Ek, R. Olsson, T. Lundbäck, D. P. Dever, T. Nishimura, A. Narla, B. Glader, H. Nakauchi, M. H. Porteus, C. E. Repellin, H. T. Gazda, S. Lin, M. Serrano, J. Flygare, K. M. Sakamoto
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/36f32df2c5f64f50a787e28db8a527f5
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spelling oai:doaj.org-article:36f32df2c5f64f50a787e28db8a527f52021-12-02T16:10:47ZDiamond Blackfan anemia is mediated by hyperactive Nemo-like kinase10.1038/s41467-020-17100-z2041-1723https://doaj.org/article/36f32df2c5f64f50a787e28db8a527f52020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17100-zhttps://doaj.org/toc/2041-1723Diamond Blackfan Anemia (DBA) is a congenital bone marrow failure syndrome that is associated with anemia. Here, the authors examine the role of Nemo-like kinase (NLK) in erythroid cells in the pathogenesis of DBA and as a potential target for therapy.M. C. WilkesK. SivaJ. ChenG. VarettiM. Y. YounH. ChaeF. EkR. OlssonT. LundbäckD. P. DeverT. NishimuraA. NarlaB. GladerH. NakauchiM. H. PorteusC. E. RepellinH. T. GazdaS. LinM. SerranoJ. FlygareK. M. SakamotoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
M. C. Wilkes
K. Siva
J. Chen
G. Varetti
M. Y. Youn
H. Chae
F. Ek
R. Olsson
T. Lundbäck
D. P. Dever
T. Nishimura
A. Narla
B. Glader
H. Nakauchi
M. H. Porteus
C. E. Repellin
H. T. Gazda
S. Lin
M. Serrano
J. Flygare
K. M. Sakamoto
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
description Diamond Blackfan Anemia (DBA) is a congenital bone marrow failure syndrome that is associated with anemia. Here, the authors examine the role of Nemo-like kinase (NLK) in erythroid cells in the pathogenesis of DBA and as a potential target for therapy.
format article
author M. C. Wilkes
K. Siva
J. Chen
G. Varetti
M. Y. Youn
H. Chae
F. Ek
R. Olsson
T. Lundbäck
D. P. Dever
T. Nishimura
A. Narla
B. Glader
H. Nakauchi
M. H. Porteus
C. E. Repellin
H. T. Gazda
S. Lin
M. Serrano
J. Flygare
K. M. Sakamoto
author_facet M. C. Wilkes
K. Siva
J. Chen
G. Varetti
M. Y. Youn
H. Chae
F. Ek
R. Olsson
T. Lundbäck
D. P. Dever
T. Nishimura
A. Narla
B. Glader
H. Nakauchi
M. H. Porteus
C. E. Repellin
H. T. Gazda
S. Lin
M. Serrano
J. Flygare
K. M. Sakamoto
author_sort M. C. Wilkes
title Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
title_short Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
title_full Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
title_fullStr Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
title_full_unstemmed Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
title_sort diamond blackfan anemia is mediated by hyperactive nemo-like kinase
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/36f32df2c5f64f50a787e28db8a527f5
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