Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals

Production of chemicals by microbial fermentation is an economical alternative to chemical synthesis. Here the authors re-engineer the yeastS. cerevisiaeto produce the very long chain fatty alcohol docosanol by expressing a heterologous Mycobacteria fatty acid synthase and a specific fatty acid redu...

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Autores principales:	Tao Yu, Yongjin J. Zhou, Leonie Wenning, Quanli Liu, Anastasia Krivoruchko, Verena Siewers, Jens Nielsen, Florian David
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36f3a67ebbcd46798748b17bc28b8b18
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spelling	oai:doaj.org-article:36f3a67ebbcd46798748b17bc28b8b182021-12-02T16:51:48ZMetabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals10.1038/ncomms155872041-1723https://doaj.org/article/36f3a67ebbcd46798748b17bc28b8b182017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15587https://doaj.org/toc/2041-1723Production of chemicals by microbial fermentation is an economical alternative to chemical synthesis. Here the authors re-engineer the yeastS. cerevisiaeto produce the very long chain fatty alcohol docosanol by expressing a heterologous Mycobacteria fatty acid synthase and a specific fatty acid reductase.Tao YuYongjin J. ZhouLeonie WenningQuanli LiuAnastasia KrivoruchkoVerena SiewersJens NielsenFlorian DavidNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tao Yu Yongjin J. Zhou Leonie Wenning Quanli Liu Anastasia Krivoruchko Verena Siewers Jens Nielsen Florian David Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals
description	Production of chemicals by microbial fermentation is an economical alternative to chemical synthesis. Here the authors re-engineer the yeastS. cerevisiaeto produce the very long chain fatty alcohol docosanol by expressing a heterologous Mycobacteria fatty acid synthase and a specific fatty acid reductase.
format	article
author	Tao Yu Yongjin J. Zhou Leonie Wenning Quanli Liu Anastasia Krivoruchko Verena Siewers Jens Nielsen Florian David
author_facet	Tao Yu Yongjin J. Zhou Leonie Wenning Quanli Liu Anastasia Krivoruchko Verena Siewers Jens Nielsen Florian David
author_sort	Tao Yu
title	Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals
title_short	Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals
title_full	Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals
title_fullStr	Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals
title_full_unstemmed	Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals
title_sort	metabolic engineering of saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/36f3a67ebbcd46798748b17bc28b8b18
work_keys_str_mv	AT taoyu metabolicengineeringofsaccharomycescerevisiaeforproductionofverylongchainfattyacidderivedchemicals AT yongjinjzhou metabolicengineeringofsaccharomycescerevisiaeforproductionofverylongchainfattyacidderivedchemicals AT leoniewenning metabolicengineeringofsaccharomycescerevisiaeforproductionofverylongchainfattyacidderivedchemicals AT quanliliu metabolicengineeringofsaccharomycescerevisiaeforproductionofverylongchainfattyacidderivedchemicals AT anastasiakrivoruchko metabolicengineeringofsaccharomycescerevisiaeforproductionofverylongchainfattyacidderivedchemicals AT verenasiewers metabolicengineeringofsaccharomycescerevisiaeforproductionofverylongchainfattyacidderivedchemicals AT jensnielsen metabolicengineeringofsaccharomycescerevisiaeforproductionofverylongchainfattyacidderivedchemicals AT floriandavid metabolicengineeringofsaccharomycescerevisiaeforproductionofverylongchainfattyacidderivedchemicals
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Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals

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