COMPARATIVE STUDIES OF IMMUNOMODULATING PROPERTIES OF C HITOSAN AND ITS DERIVATIVES

Abstract. Comparative study was carried out, aiming to assess immunostimulatory properties of high-molecular chitosan (Ch-HM) and its derivatives, i.e., low molecular weight chitosan (Ch-LM), N-3-hydroxymyristoyl (Ch-LM) at a low acylation ratio, N-3-hydroxymyristoylchitooligosaccharides (N-acylchit...

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Autores principales:	L. A. Ivanushko, T. F. Solovyeva, T. S. Zaporozhets, P. A. Lukyanov, V. I. Gorbach, N. N. Besednova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chitosan immunomodulators Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/36f42f2212614ca08e4f91868d8e5cee
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spelling	oai:doaj.org-article:36f42f2212614ca08e4f91868d8e5cee2021-11-18T08:03:39ZCOMPARATIVE STUDIES OF IMMUNOMODULATING PROPERTIES OF C HITOSAN AND ITS DERIVATIVES1563-06252313-741X10.15789/1563-0625-2007-4-5-397-404https://doaj.org/article/36f42f2212614ca08e4f91868d8e5cee2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/188https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Comparative study was carried out, aiming to assess immunostimulatory properties of high-molecular chitosan (Ch-HM) and its derivatives, i.e., low molecular weight chitosan (Ch-LM), N-3-hydroxymyristoyl (Ch-LM) at a low acylation ratio, N-3-hydroxymyristoylchitooligosaccharides (N-acylchito-biose, -triose, -tetraose), N-, O-carboxyalkylchitosans (carboxymethyl, -ethyl, -propyl derivates). It was established, that the chemical modifications of chitosan influenced its biological activity. The derivatives of chitosan were found to have improved physical properties (good solubility in neutral and alkaline solutions, low viscosity in acidic solutions, good absorption from a gastrointestinal compartment), as compared with initial (high molecular weight) chitosan formula. They possess immunomodulatory properties and may be regarded as promising substances for preparation of medical drugs and biologically active food additives (BAFA).L. A. IvanushkoT. F. SolovyevaT. S. ZaporozhetsP. A. LukyanovV. I. GorbachN. N. BesednovaSPb RAACIarticlechitosanimmunomodulatorsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 397-404 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chitosan immunomodulators Immunologic diseases. Allergy RC581-607
spellingShingle	chitosan immunomodulators Immunologic diseases. Allergy RC581-607 L. A. Ivanushko T. F. Solovyeva T. S. Zaporozhets P. A. Lukyanov V. I. Gorbach N. N. Besednova COMPARATIVE STUDIES OF IMMUNOMODULATING PROPERTIES OF C HITOSAN AND ITS DERIVATIVES
description	Abstract. Comparative study was carried out, aiming to assess immunostimulatory properties of high-molecular chitosan (Ch-HM) and its derivatives, i.e., low molecular weight chitosan (Ch-LM), N-3-hydroxymyristoyl (Ch-LM) at a low acylation ratio, N-3-hydroxymyristoylchitooligosaccharides (N-acylchito-biose, -triose, -tetraose), N-, O-carboxyalkylchitosans (carboxymethyl, -ethyl, -propyl derivates). It was established, that the chemical modifications of chitosan influenced its biological activity. The derivatives of chitosan were found to have improved physical properties (good solubility in neutral and alkaline solutions, low viscosity in acidic solutions, good absorption from a gastrointestinal compartment), as compared with initial (high molecular weight) chitosan formula. They possess immunomodulatory properties and may be regarded as promising substances for preparation of medical drugs and biologically active food additives (BAFA).
format	article
author	L. A. Ivanushko T. F. Solovyeva T. S. Zaporozhets P. A. Lukyanov V. I. Gorbach N. N. Besednova
author_facet	L. A. Ivanushko T. F. Solovyeva T. S. Zaporozhets P. A. Lukyanov V. I. Gorbach N. N. Besednova
author_sort	L. A. Ivanushko
title	COMPARATIVE STUDIES OF IMMUNOMODULATING PROPERTIES OF C HITOSAN AND ITS DERIVATIVES
title_short	COMPARATIVE STUDIES OF IMMUNOMODULATING PROPERTIES OF C HITOSAN AND ITS DERIVATIVES
title_full	COMPARATIVE STUDIES OF IMMUNOMODULATING PROPERTIES OF C HITOSAN AND ITS DERIVATIVES
title_fullStr	COMPARATIVE STUDIES OF IMMUNOMODULATING PROPERTIES OF C HITOSAN AND ITS DERIVATIVES
title_full_unstemmed	COMPARATIVE STUDIES OF IMMUNOMODULATING PROPERTIES OF C HITOSAN AND ITS DERIVATIVES
title_sort	comparative studies of immunomodulating properties of c hitosan and its derivatives
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/36f42f2212614ca08e4f91868d8e5cee
work_keys_str_mv	AT laivanushko comparativestudiesofimmunomodulatingpropertiesofchitosananditsderivatives AT tfsolovyeva comparativestudiesofimmunomodulatingpropertiesofchitosananditsderivatives AT tszaporozhets comparativestudiesofimmunomodulatingpropertiesofchitosananditsderivatives AT palukyanov comparativestudiesofimmunomodulatingpropertiesofchitosananditsderivatives AT vigorbach comparativestudiesofimmunomodulatingpropertiesofchitosananditsderivatives AT nnbesednova comparativestudiesofimmunomodulatingpropertiesofchitosananditsderivatives
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COMPARATIVE STUDIES OF IMMUNOMODULATING PROPERTIES OF C HITOSAN AND ITS DERIVATIVES

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