Restoration of the molecular clock is tumor suppressive in neuroblastoma
MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neuroblastoma growth
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/36f78ce6f76041c49c8161f0733a70f4 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:36f78ce6f76041c49c8161f0733a70f4 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:36f78ce6f76041c49c8161f0733a70f42021-12-02T14:34:05ZRestoration of the molecular clock is tumor suppressive in neuroblastoma10.1038/s41467-021-24196-42041-1723https://doaj.org/article/36f78ce6f76041c49c8161f0733a70f42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24196-4https://doaj.org/toc/2041-1723MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neuroblastoma growthMyrthala Moreno-SmithGiorgio MilazzoLing TaoBaharan FekryBokai ZhuMahmoud A. MohammadSimone Di GiacomoRoshan BorkarKarthik Reddy Kami ReddyMario CapassoSanjeev A. VasudevanPavel SumazinJohn HicksNagireddy PutluriGiovanni PeriniKristin Eckel-MahanThomas P. BurrisEveline BarbieriNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Myrthala Moreno-Smith Giorgio Milazzo Ling Tao Baharan Fekry Bokai Zhu Mahmoud A. Mohammad Simone Di Giacomo Roshan Borkar Karthik Reddy Kami Reddy Mario Capasso Sanjeev A. Vasudevan Pavel Sumazin John Hicks Nagireddy Putluri Giovanni Perini Kristin Eckel-Mahan Thomas P. Burris Eveline Barbieri Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| description |
MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neuroblastoma growth |
| format |
article |
| author |
Myrthala Moreno-Smith Giorgio Milazzo Ling Tao Baharan Fekry Bokai Zhu Mahmoud A. Mohammad Simone Di Giacomo Roshan Borkar Karthik Reddy Kami Reddy Mario Capasso Sanjeev A. Vasudevan Pavel Sumazin John Hicks Nagireddy Putluri Giovanni Perini Kristin Eckel-Mahan Thomas P. Burris Eveline Barbieri |
| author_facet |
Myrthala Moreno-Smith Giorgio Milazzo Ling Tao Baharan Fekry Bokai Zhu Mahmoud A. Mohammad Simone Di Giacomo Roshan Borkar Karthik Reddy Kami Reddy Mario Capasso Sanjeev A. Vasudevan Pavel Sumazin John Hicks Nagireddy Putluri Giovanni Perini Kristin Eckel-Mahan Thomas P. Burris Eveline Barbieri |
| author_sort |
Myrthala Moreno-Smith |
| title |
Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| title_short |
Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| title_full |
Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| title_fullStr |
Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| title_full_unstemmed |
Restoration of the molecular clock is tumor suppressive in neuroblastoma |
| title_sort |
restoration of the molecular clock is tumor suppressive in neuroblastoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/36f78ce6f76041c49c8161f0733a70f4 |
| work_keys_str_mv |
AT myrthalamorenosmith restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT giorgiomilazzo restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT lingtao restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT baharanfekry restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT bokaizhu restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT mahmoudamohammad restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT simonedigiacomo restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT roshanborkar restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT karthikreddykamireddy restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT mariocapasso restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT sanjeevavasudevan restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT pavelsumazin restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT johnhicks restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT nagireddyputluri restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT giovanniperini restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT kristineckelmahan restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT thomaspburris restorationofthemolecularclockistumorsuppressiveinneuroblastoma AT evelinebarbieri restorationofthemolecularclockistumorsuppressiveinneuroblastoma |
| _version_ |
1718391121691803648 |