Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

Monoclonal antibodies are highly effective therapeutics that can be delivered as proteins or encoded DNA or mRNA. Here the authors develop lipid nanoparticle-formulated nucleoside-modified mRNA encoding an HIV-1 neutralizing antibody and see sustained and protective antibody levels in treated mice.

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Autores principales: Norbert Pardi, Anthony J. Secreto, Xiaochuan Shan, Fotini Debonera, Joshua Glover, Yanjie Yi, Hiromi Muramatsu, Houping Ni, Barbara L. Mui, Ying K. Tam, Farida Shaheen, Ronald G. Collman, Katalin Karikó, Gwenn A. Danet-Desnoyers, Thomas D. Madden, Michael J. Hope, Drew Weissman
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/36f809ffcf28468fac50f32ddc0d7fa0
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spelling oai:doaj.org-article:36f809ffcf28468fac50f32ddc0d7fa02021-12-02T17:06:24ZAdministration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge10.1038/ncomms146302041-1723https://doaj.org/article/36f809ffcf28468fac50f32ddc0d7fa02017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14630https://doaj.org/toc/2041-1723Monoclonal antibodies are highly effective therapeutics that can be delivered as proteins or encoded DNA or mRNA. Here the authors develop lipid nanoparticle-formulated nucleoside-modified mRNA encoding an HIV-1 neutralizing antibody and see sustained and protective antibody levels in treated mice.Norbert PardiAnthony J. SecretoXiaochuan ShanFotini DeboneraJoshua GloverYanjie YiHiromi MuramatsuHouping NiBarbara L. MuiYing K. TamFarida ShaheenRonald G. CollmanKatalin KarikóGwenn A. Danet-DesnoyersThomas D. MaddenMichael J. HopeDrew WeissmanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Norbert Pardi
Anthony J. Secreto
Xiaochuan Shan
Fotini Debonera
Joshua Glover
Yanjie Yi
Hiromi Muramatsu
Houping Ni
Barbara L. Mui
Ying K. Tam
Farida Shaheen
Ronald G. Collman
Katalin Karikó
Gwenn A. Danet-Desnoyers
Thomas D. Madden
Michael J. Hope
Drew Weissman
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
description Monoclonal antibodies are highly effective therapeutics that can be delivered as proteins or encoded DNA or mRNA. Here the authors develop lipid nanoparticle-formulated nucleoside-modified mRNA encoding an HIV-1 neutralizing antibody and see sustained and protective antibody levels in treated mice.
format article
author Norbert Pardi
Anthony J. Secreto
Xiaochuan Shan
Fotini Debonera
Joshua Glover
Yanjie Yi
Hiromi Muramatsu
Houping Ni
Barbara L. Mui
Ying K. Tam
Farida Shaheen
Ronald G. Collman
Katalin Karikó
Gwenn A. Danet-Desnoyers
Thomas D. Madden
Michael J. Hope
Drew Weissman
author_facet Norbert Pardi
Anthony J. Secreto
Xiaochuan Shan
Fotini Debonera
Joshua Glover
Yanjie Yi
Hiromi Muramatsu
Houping Ni
Barbara L. Mui
Ying K. Tam
Farida Shaheen
Ronald G. Collman
Katalin Karikó
Gwenn A. Danet-Desnoyers
Thomas D. Madden
Michael J. Hope
Drew Weissman
author_sort Norbert Pardi
title Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
title_short Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
title_full Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
title_fullStr Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
title_full_unstemmed Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
title_sort administration of nucleoside-modified mrna encoding broadly neutralizing antibody protects humanized mice from hiv-1 challenge
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/36f809ffcf28468fac50f32ddc0d7fa0
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