Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
Monoclonal antibodies are highly effective therapeutics that can be delivered as proteins or encoded DNA or mRNA. Here the authors develop lipid nanoparticle-formulated nucleoside-modified mRNA encoding an HIV-1 neutralizing antibody and see sustained and protective antibody levels in treated mice.
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Nature Portfolio
2017
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oai:doaj.org-article:36f809ffcf28468fac50f32ddc0d7fa02021-12-02T17:06:24ZAdministration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge10.1038/ncomms146302041-1723https://doaj.org/article/36f809ffcf28468fac50f32ddc0d7fa02017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14630https://doaj.org/toc/2041-1723Monoclonal antibodies are highly effective therapeutics that can be delivered as proteins or encoded DNA or mRNA. Here the authors develop lipid nanoparticle-formulated nucleoside-modified mRNA encoding an HIV-1 neutralizing antibody and see sustained and protective antibody levels in treated mice.Norbert PardiAnthony J. SecretoXiaochuan ShanFotini DeboneraJoshua GloverYanjie YiHiromi MuramatsuHouping NiBarbara L. MuiYing K. TamFarida ShaheenRonald G. CollmanKatalin KarikóGwenn A. Danet-DesnoyersThomas D. MaddenMichael J. HopeDrew WeissmanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
spellingShingle |
Science Q Norbert Pardi Anthony J. Secreto Xiaochuan Shan Fotini Debonera Joshua Glover Yanjie Yi Hiromi Muramatsu Houping Ni Barbara L. Mui Ying K. Tam Farida Shaheen Ronald G. Collman Katalin Karikó Gwenn A. Danet-Desnoyers Thomas D. Madden Michael J. Hope Drew Weissman Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge |
description |
Monoclonal antibodies are highly effective therapeutics that can be delivered as proteins or encoded DNA or mRNA. Here the authors develop lipid nanoparticle-formulated nucleoside-modified mRNA encoding an HIV-1 neutralizing antibody and see sustained and protective antibody levels in treated mice. |
format |
article |
author |
Norbert Pardi Anthony J. Secreto Xiaochuan Shan Fotini Debonera Joshua Glover Yanjie Yi Hiromi Muramatsu Houping Ni Barbara L. Mui Ying K. Tam Farida Shaheen Ronald G. Collman Katalin Karikó Gwenn A. Danet-Desnoyers Thomas D. Madden Michael J. Hope Drew Weissman |
author_facet |
Norbert Pardi Anthony J. Secreto Xiaochuan Shan Fotini Debonera Joshua Glover Yanjie Yi Hiromi Muramatsu Houping Ni Barbara L. Mui Ying K. Tam Farida Shaheen Ronald G. Collman Katalin Karikó Gwenn A. Danet-Desnoyers Thomas D. Madden Michael J. Hope Drew Weissman |
author_sort |
Norbert Pardi |
title |
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge |
title_short |
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge |
title_full |
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge |
title_fullStr |
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge |
title_full_unstemmed |
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge |
title_sort |
administration of nucleoside-modified mrna encoding broadly neutralizing antibody protects humanized mice from hiv-1 challenge |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/36f809ffcf28468fac50f32ddc0d7fa0 |
work_keys_str_mv |
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