Extended haplotype-phasing of long-read de novo genome assemblies using Hi-C
Methods to produce haplotype-resolved genome assemblies often rely on access to family trios. The authors present FALCON-Phase, a tool that combines ultra-long range Hi-C chromatin interaction data with a long read de novo assembly to extend haplotype phasing to the contig or scaffold level.
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Nature Portfolio
2021
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oai:doaj.org-article:36f8c0b7e92d40fdb0d367dee6cfc4622021-12-02T17:17:17ZExtended haplotype-phasing of long-read de novo genome assemblies using Hi-C10.1038/s41467-020-20536-y2041-1723https://doaj.org/article/36f8c0b7e92d40fdb0d367dee6cfc4622021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20536-yhttps://doaj.org/toc/2041-1723Methods to produce haplotype-resolved genome assemblies often rely on access to family trios. The authors present FALCON-Phase, a tool that combines ultra-long range Hi-C chromatin interaction data with a long read de novo assembly to extend haplotype phasing to the contig or scaffold level.Zev N. KronenbergArang RhieSergey KorenGregory T. ConcepcionPaul PelusoKatherine M. MunsonDavid PorubskyKristen KuhnKathryn A. MuellerWai Yee LowStefan HiendlederOlivier FedrigoIvan LiachkoRichard J. HallAdam M. PhillippyEvan E. EichlerJohn L. WilliamsTimothy P. L. SmithErich D. JarvisShawn T. SullivanSarah B. KinganNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Zev N. Kronenberg Arang Rhie Sergey Koren Gregory T. Concepcion Paul Peluso Katherine M. Munson David Porubsky Kristen Kuhn Kathryn A. Mueller Wai Yee Low Stefan Hiendleder Olivier Fedrigo Ivan Liachko Richard J. Hall Adam M. Phillippy Evan E. Eichler John L. Williams Timothy P. L. Smith Erich D. Jarvis Shawn T. Sullivan Sarah B. Kingan Extended haplotype-phasing of long-read de novo genome assemblies using Hi-C |
| description |
Methods to produce haplotype-resolved genome assemblies often rely on access to family trios. The authors present FALCON-Phase, a tool that combines ultra-long range Hi-C chromatin interaction data with a long read de novo assembly to extend haplotype phasing to the contig or scaffold level. |
| format |
article |
| author |
Zev N. Kronenberg Arang Rhie Sergey Koren Gregory T. Concepcion Paul Peluso Katherine M. Munson David Porubsky Kristen Kuhn Kathryn A. Mueller Wai Yee Low Stefan Hiendleder Olivier Fedrigo Ivan Liachko Richard J. Hall Adam M. Phillippy Evan E. Eichler John L. Williams Timothy P. L. Smith Erich D. Jarvis Shawn T. Sullivan Sarah B. Kingan |
| author_facet |
Zev N. Kronenberg Arang Rhie Sergey Koren Gregory T. Concepcion Paul Peluso Katherine M. Munson David Porubsky Kristen Kuhn Kathryn A. Mueller Wai Yee Low Stefan Hiendleder Olivier Fedrigo Ivan Liachko Richard J. Hall Adam M. Phillippy Evan E. Eichler John L. Williams Timothy P. L. Smith Erich D. Jarvis Shawn T. Sullivan Sarah B. Kingan |
| author_sort |
Zev N. Kronenberg |
| title |
Extended haplotype-phasing of long-read de novo genome assemblies using Hi-C |
| title_short |
Extended haplotype-phasing of long-read de novo genome assemblies using Hi-C |
| title_full |
Extended haplotype-phasing of long-read de novo genome assemblies using Hi-C |
| title_fullStr |
Extended haplotype-phasing of long-read de novo genome assemblies using Hi-C |
| title_full_unstemmed |
Extended haplotype-phasing of long-read de novo genome assemblies using Hi-C |
| title_sort |
extended haplotype-phasing of long-read de novo genome assemblies using hi-c |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/36f8c0b7e92d40fdb0d367dee6cfc462 |
| work_keys_str_mv |
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