Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians

Between 5 and 15% of latent Mycobacterium tuberculosis infections develop into active tuberculosis (TB). Here, Luo et al. report a genome-wide association study for early TB progression in a total of 4002 active TB cases and their household contacts in Peru and they identify a locus on 3q23 in which...

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Autores principales:	Yang Luo, Sara Suliman, Samira Asgari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martínez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Leonid Lecca, Segundo R. León, Judith Jimenez, Rosa Yataco, Carmen Contreras, Jerome T. Galea, Mercedes Becerra, Sergey Nejentsev, Peter A. Nigrovic, D. Branch Moody, Megan B. Murray, Soumya Raychaudhuri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/36fa9a1eb19843fd9794c63c4cc444fd
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spelling	oai:doaj.org-article:36fa9a1eb19843fd9794c63c4cc444fd2021-12-02T14:39:39ZEarly progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians10.1038/s41467-019-11664-12041-1723https://doaj.org/article/36fa9a1eb19843fd9794c63c4cc444fd2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11664-1https://doaj.org/toc/2041-1723Between 5 and 15% of latent Mycobacterium tuberculosis infections develop into active tuberculosis (TB). Here, Luo et al. report a genome-wide association study for early TB progression in a total of 4002 active TB cases and their household contacts in Peru and they identify a locus on 3q23 in which ATP1B3 is mapped as the likely causal gene.Yang LuoSara SulimanSamira AsgariTiffany AmariutaYuriy BaglaenkoMarta Martínez-BonetKazuyoshi IshigakiMaria Gutierrez-ArcelusRoger CalderonLeonid LeccaSegundo R. LeónJudith JimenezRosa YatacoCarmen ContrerasJerome T. GaleaMercedes BecerraSergey NejentsevPeter A. NigrovicD. Branch MoodyMegan B. MurraySoumya RaychaudhuriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Luo Sara Suliman Samira Asgari Tiffany Amariuta Yuriy Baglaenko Marta Martínez-Bonet Kazuyoshi Ishigaki Maria Gutierrez-Arcelus Roger Calderon Leonid Lecca Segundo R. León Judith Jimenez Rosa Yataco Carmen Contreras Jerome T. Galea Mercedes Becerra Sergey Nejentsev Peter A. Nigrovic D. Branch Moody Megan B. Murray Soumya Raychaudhuri Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
description	Between 5 and 15% of latent Mycobacterium tuberculosis infections develop into active tuberculosis (TB). Here, Luo et al. report a genome-wide association study for early TB progression in a total of 4002 active TB cases and their household contacts in Peru and they identify a locus on 3q23 in which ATP1B3 is mapped as the likely causal gene.
format	article
author	Yang Luo Sara Suliman Samira Asgari Tiffany Amariuta Yuriy Baglaenko Marta Martínez-Bonet Kazuyoshi Ishigaki Maria Gutierrez-Arcelus Roger Calderon Leonid Lecca Segundo R. León Judith Jimenez Rosa Yataco Carmen Contreras Jerome T. Galea Mercedes Becerra Sergey Nejentsev Peter A. Nigrovic D. Branch Moody Megan B. Murray Soumya Raychaudhuri
author_facet	Yang Luo Sara Suliman Samira Asgari Tiffany Amariuta Yuriy Baglaenko Marta Martínez-Bonet Kazuyoshi Ishigaki Maria Gutierrez-Arcelus Roger Calderon Leonid Lecca Segundo R. León Judith Jimenez Rosa Yataco Carmen Contreras Jerome T. Galea Mercedes Becerra Sergey Nejentsev Peter A. Nigrovic D. Branch Moody Megan B. Murray Soumya Raychaudhuri
author_sort	Yang Luo
title	Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
title_short	Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
title_full	Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
title_fullStr	Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
title_full_unstemmed	Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians
title_sort	early progression to active tuberculosis is a highly heritable trait driven by 3q23 in peruvians
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/36fa9a1eb19843fd9794c63c4cc444fd
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Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians

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