Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments

Shang Song1, Yupeng Chen1,2, Zhimin Yan4, Hicham Fenniri4, Thomas J Webster1,31School of Engineering, 2Department of Chemistry, 3Department of Orthopaedics, Brown University, Providence, RI, USA; 4National Institute for Nanotechnology and Department of Chemistry, National Research Council and Univer...

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Autores principales:	Shang Song, Yupeng Chen, Zhimin Yan, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/370195b17cad41ccb1d092c0e1959b92
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spelling	oai:doaj.org-article:370195b17cad41ccb1d092c0e1959b922021-12-02T02:57:18ZSelf-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments1176-91141178-2013https://doaj.org/article/370195b17cad41ccb1d092c0e1959b922011-01-01T00:00:00Zhttp://www.dovepress.com/self-assembled-rosette-nanotubes-for-incorporating-hydrophobic-drugs-i-a6024https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Shang Song1, Yupeng Chen1,2, Zhimin Yan4, Hicham Fenniri4, Thomas J Webster1,31School of Engineering, 2Department of Chemistry, 3Department of Orthopaedics, Brown University, Providence, RI, USA; 4National Institute for Nanotechnology and Department of Chemistry, National Research Council and University of Alberta, Edmonton, CanadaAbstract: Rosette nanotubes (RNTs) are novel, biomimetic, injectable, self-assembled nanomaterials. In previous studies, materials coated with RNTs have significantly increased cell growth (eg, osteoblasts, chondrocytes, and endothelial cells) due to the favorable cellular environment created by RNTs. It has also been suggested that the tubular RNT structures formed by base stacking and hydrophobic interactions can be used for drug delivery, and this possibility has not been studied to date. Here we investigated methods to load and deliver tamoxifen (TAM, a hydrophobic anticancer drug) using two different types of RNTs: single-base RNTs and twin-base RNTs. Drug-loaded RNTs were characterized by nuclear magnetic resonance spectroscopy, diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY NMR), and ultraviolet-visible (UV-Vis) spectroscopy at different ratios of twin-base RNTs to TAM. The results demonstrated successful incorporation of hydrophobic TAM into RNTs. Importantly, because of the hydrophilicity of the outer surface of the RNTs, TAM-loaded RNTs were dissolved in water, and thus have great potential to deliver hydrophobic drugs in various physiological environments. The results also showed that twin-base RNTs further improved TAM loading. Therefore, this study demonstrated that hydrophobic pharmaceutical agents (such as TAM), once considered hard to deliver, can be easily incorporated into RNTs for anticancer treatment purposes.Keywords: drug delivery, rosette nanotubes, self-assembly, tamoxifen Shang SongYupeng ChenZhimin Yanet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 101-107 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Shang Song Yupeng Chen Zhimin Yan et al Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
description	Shang Song1, Yupeng Chen1,2, Zhimin Yan4, Hicham Fenniri4, Thomas J Webster1,31School of Engineering, 2Department of Chemistry, 3Department of Orthopaedics, Brown University, Providence, RI, USA; 4National Institute for Nanotechnology and Department of Chemistry, National Research Council and University of Alberta, Edmonton, CanadaAbstract: Rosette nanotubes (RNTs) are novel, biomimetic, injectable, self-assembled nanomaterials. In previous studies, materials coated with RNTs have significantly increased cell growth (eg, osteoblasts, chondrocytes, and endothelial cells) due to the favorable cellular environment created by RNTs. It has also been suggested that the tubular RNT structures formed by base stacking and hydrophobic interactions can be used for drug delivery, and this possibility has not been studied to date. Here we investigated methods to load and deliver tamoxifen (TAM, a hydrophobic anticancer drug) using two different types of RNTs: single-base RNTs and twin-base RNTs. Drug-loaded RNTs were characterized by nuclear magnetic resonance spectroscopy, diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY NMR), and ultraviolet-visible (UV-Vis) spectroscopy at different ratios of twin-base RNTs to TAM. The results demonstrated successful incorporation of hydrophobic TAM into RNTs. Importantly, because of the hydrophilicity of the outer surface of the RNTs, TAM-loaded RNTs were dissolved in water, and thus have great potential to deliver hydrophobic drugs in various physiological environments. The results also showed that twin-base RNTs further improved TAM loading. Therefore, this study demonstrated that hydrophobic pharmaceutical agents (such as TAM), once considered hard to deliver, can be easily incorporated into RNTs for anticancer treatment purposes.Keywords: drug delivery, rosette nanotubes, self-assembly, tamoxifen
format	article
author	Shang Song Yupeng Chen Zhimin Yan et al
author_facet	Shang Song Yupeng Chen Zhimin Yan et al
author_sort	Shang Song
title	Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title_short	Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title_full	Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title_fullStr	Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title_full_unstemmed	Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title_sort	self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/370195b17cad41ccb1d092c0e1959b92
work_keys_str_mv	AT shangsong selfassembledrosettenanotubesforincorporatinghydrophobicdrugsinphysiologicalenvironments AT yupengchen selfassembledrosettenanotubesforincorporatinghydrophobicdrugsinphysiologicalenvironments AT zhiminyan selfassembledrosettenanotubesforincorporatinghydrophobicdrugsinphysiologicalenvironments AT etal selfassembledrosettenanotubesforincorporatinghydrophobicdrugsinphysiologicalenvironments
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Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments

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